ID H3G5R3_PHYRM Unreviewed; 830 AA.
AC H3G5R3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Upf1 domain-containing protein {ECO:0000259|PROSITE:PS51997};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra42910, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra42910}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra42910};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; DS566014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3G5R3; -.
DR STRING; 164328.H3G5R3; -.
DR EnsemblProtists; Phyra42910; Phyra42910; Phyra42910.
DR VEuPathDB; FungiDB:PSURA_42910; -.
DR eggNOG; KOG1802; Eukaryota.
DR HOGENOM; CLU_001666_4_4_1; -.
DR InParanoid; H3G5R3; -.
DR OMA; VRSNDNQ; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 24..181
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 32..64
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 46..74
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 92..122
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
SQ SEQUENCE 830 AA; 92915 MW; 3EA95C5F3E3CD504 CRC64;
SLAGDFQSLT FDETADEDAL EYTTRELPKH ACAYCGLHEP ASVVKCVASD KWFCNSRGNT
SGSHIIQHLV RSKNKEVSLH PESPLGETVL ECYNCGCRNA FLLGFIPAKQ DSVVVLLCRD
PCLQMNALKD MSWDMSQWLP IIEDRSFLPW LVKVPSEHEQ LRARQITSSQ IAKLEELWRD
NPLATVEDLD RPGIDDEPVE VTPMYDDGYQ YQNIFGPLVK MESDYDKKMK ESQTQEGVMV
RWDTGLNKKR NAIFTCSRPD SDLRLVPGDE IRLRLGPTAS MLYGKDWEGT GHVLRLDESE
VALEMRSNNV PMEITDGYLV DFVWKSTSFD RMQAAMKTFA VDDTSLTGYL YHKILGHAVD
VQPLRIPRSV GTHFSAPGLP ELNPPQMEAV KGVLEQPLSL IQGPPGTGKT VTSASIVFHM
SKQNMGQVLV TAPSNIAVDH LTMKISATGL RVVRLAAKSR EAVASSVEHL SLHAMIKSLD
SPDKADLRKL MQLKDDQGEL SSQDEKRFKS LKRQAEREIL QAADVICTTC VGAGDPRLSN
FRFRQVLIDE ATQATEPECL IPIVQGAKHV VMVGDHRQLG PVVMNKKAAS AGLNQSLFDR
LLQLNHRPFR LRVQYRMHPF LSEFPSNQFY EGELQNGVSA SERQLSNVDF PWPNPNKPTF
FYICLGAEEI SSSGTSYLNR TEASNVEKIV TAFLKAGVLP AQIGVVTPYE GQRAYVVSYM
QRNGPMRSQL YKDVEVASVD SFQGREKDLI ILSCVRSNEN QGIGFLSDKR RLNVALTRAK
YGVIVLGNPR VLAKQPLWNT LLNHYRDNQL IVEGPLNNLT PSHMQFPPPK
//
