ID H3G9I5_PHYRM Unreviewed; 527 AA.
AC H3G9I5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Cystathionine gamma-synthase {ECO:0008006|Google:ProtNLM};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra71682, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra71682}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra71682};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
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DR EMBL; DS566034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3G9I5; -.
DR STRING; 164328.H3G9I5; -.
DR EnsemblProtists; Phyra71682; Phyra71682; Phyra71682.
DR VEuPathDB; FungiDB:PSURA_71682; -.
DR eggNOG; KOG0053; Eukaryota.
DR HOGENOM; CLU_011302_1_0_1; -.
DR InParanoid; H3G9I5; -.
DR OMA; HYQELDE; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0003962; F:cystathionine gamma-synthase activity; IBA:GO_Central.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IBA:GO_Central.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR42699; -; 1.
DR PANTHER; PTHR42699:SF1; CYSTATHIONINE GAMMA-SYNTHASE-RELATED; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|RuleBase:RU362118};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238}.
SQ SEQUENCE 527 AA; 57815 MW; 578094173B7B441F CRC64;
MSSLTPEPLG SSLPPRNSHA ISVSMPDWAH VVGYEEALPE VLDAMACGYP RFFRHPLVVA
LSGVIQSQRF PEDDVDLWEI VPVPTSAVAE RLRHFLVDSN QATVTPDQVS VHVIKEVVHV
VRFPRRLSAT AKQFWQHSGE IVSSRHAEKL LQLLQTEQVQ APALGQTNNH LALKRRVSEL
YLPSADPTKV ALYPTGMGAI FSCVRMLQKL RGAECKSILV GFPYVDTLKI LSRKEWCPQG
VHFFPACGDK QMQEVEAIVA QEKVLAIFTE FPGNPLLSMP DLKRLAKCAH DNGTVLVVDD
TVGSYNVNTM QHGCADLVAT SLSKIFGGKG DVMGGSVVLN PEGPKAKELE ALFDPEEDSF
IVEDDVEVLL EQSEDLAERL AKTNVTTADI VQRLLKHPMV KEVFYPTLGD AKNLYDPFLN
PSESTDQPRY GPLLSILLPG GLEPAKAFYN ALKIAKGPSL GTNFTLSCPY TLLAHYGELD
FVESCGVDRN LIRISIGQED PGVIWADFEQ AFAAASVFIT PETSASK
//
