ID H3GM82_PHYRM Unreviewed; 4708 AA.
AC H3GM82;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra77577, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra77577}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra77577};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; DS566022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 164328.H3GM82; -.
DR EnsemblProtists; Phyra77577; Phyra77577; Phyra77577.
DR VEuPathDB; FungiDB:PSURA_77577; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_7_0_1; -.
DR InParanoid; H3GM82; -.
DR OMA; NERQMTR; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238}.
FT DOMAIN 1923..2082
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2600..2750
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2948..3115
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 139..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3232..3291
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3448..3489
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3752..3818
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 139..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4708 AA; 532081 MW; 92316156B348DB4B CRC64;
MASSADVTAP AADVLPVADF QRYLLATCMP LFGEGAALTV ERFKGDLEAA DAVITLDQFV
SDSATRVLQV HCFPPRADED SPMDGSVAGY RVRVNLGIAY SSGKKSGHDV VCFIKRFSAP
LAKDQTLNHQ LQVMTLGLGS SAGGDKTDSD TATASSGENT EEEEEDRGNL LSVVYNYVHQ
SFTPLVNEYS KVHQPQSEIT NASEGTRGLP AIRRRMKELE LALLQYQQNI EIPEVNLISH
PVIQQAADLV REKGVLIDVE ALGLEDKVND VVFVNNIQGG VSKWIKEIQK VTRLINEPLP
GTTMQEINFW CDLNRALLAV QEKLKSPEVE ITLAVLQRAK RYLATVTFSA DHGLGPAVQH
VSSVMTLMKE FPMNSILSAT DINQLNQGVT LVFTHLKKIR VADAYNLSRL LRLVEVMSSD
LTQQVISLLR VYSLIQVPFH QFEQLISSCK ELFSNWHRQV ATLYDLSKEL FKRRGGSINT
EKLPLLSELQ MEHVAIEERL LELYEFREQH EKLREVIQRV LGGSNTIGLD EQRGGDGTND
ALTEINSAYS QLNSLDPLDV SSEGTTAWKN LRKAYDLCID RVEGRIISSL TSRLSATSNA
DEMFRVFSKY NALFFRPRIR SAVQQFQMQL IENVKEDVSS LQAKFRAHYA YSEASRTSKL
RDIPPIAGAV MWAKQIERKL KMLLSRVESV LGVGWEQHVE GKALKAAAEA FIAKLNPQLI
FDQWVNDLAS MPIFDIKNII LNIVTEDTPH GEKKKLVVAF NQQIVTLFKE VRNLEWLGYR
VPFTLKMIAE DAKSKYPFAM SLDASLKTYT SSCRRIQPIF EALTAAYVRE VRATIGKTFT
KGNEMRWHAD GLGEYVSDLA AKVERLHDKV DDLLQKASDI DTLLESVRSS SDFQPGDVQA
VLVKIQAHVD ELSLAGYANL HVFVKNLNTL ISEILGKKLG VLLQRWVACF GPQPDEKSFQ
AALSDAGLTV TTHQILLKNQ VLYLEPSVGD ARRDWLAQLQ NLLNSVCDLS KIQTSSYENV
YGKSTVSALS SPPRKSASSR RREAVFKEAL NQVPLELLTK AYSVLDLTVN DVEKYASTWL
QYQALWDMDA QTALNSVGED LRKWQQILVE IKNERNAFDA VFNTKRFGPM VINYQQVQAQ
VNVKYDAWHN EFLAYFGDLL RDQINSFYST ISSKRTLLEQ HALEAATAQV VAAITLIQEM
RQMRVQWEEA VESFEQGERL LKKQRYRFSA DWPSLANVEG EWEAFIQLLK RKTAAMESQL
PQLQAKIMEE KSALDSKISK AVTEWDSAKP LQGAQSPKAA TELLIIYDTR FKLLRGEQDK
TNAALDALNI SYVSGMGGSS INDDRSSYGD LSRAMEELSG LDEVWKNISK VWAHVDELQD
TLWSAVHPRK VRKQLDEIVE EMRRFPARVQ QYEAFEHFAS LIQSRKAMSS LLSELKSDAV
RDRHWKQILR LLDISSPFTE LTLRSFWESK ISANDNELKS IIRTAQGEMA LDEFLRQVSD
YWTNYQLDLV NYQNRCRVIR GWDEMFAKLD EHLNSLSSMK QSPYYRVFAE LATSWEDKLT
RIRGILDFWI DVQRRWVYLE GIFFGSADIK QQLPKEFARF QSVDNEFTST MKRVAHKPMI
VDVANIPNLY HSLERQQDMM GNVQRALGEY LERQRAAFPR FYFVGDEDLL EMIGNSKEPM
QIQRHLSKMF AGISSLEMDS STGVILGMVS REGEVVRFKE PVKTTEDTRI NVWLGKVEEQ
MRKTLSLLLE EAVRTYPSDD SAETYLKWVS EFPAQVVILA TQVQWSNEVE NMLKAGGGNL
SAVLGQLDKL LLILSERVLT DVKNDVRKKY EQLITELVHQ KSVTKRLSQA KVSSAEDFRW
LYHMRHYFQA KESDPLKKLT IQISNASFSY GFEYFGVGER LVQTPLTERC YLTLTQALDF
GMGGNPFGPA GTGKTESVKA LGSHLGRFVL VFNCDEHFDF QAMGRIFVGL CQVGAWGCFD
EFNRLEERVL SAVSQQILAI QSGVSSLKVG KTADSSQTIT NGSSTTIELL GKSVKLNPDV
GIFVTMNPGY AGRSNLPDNL KQLFRSIAMV APDRELIAQV MLFSQGITTA EQISAKVVLL
FNLCEDQLSK QPHYDFGLRA LKSVLVSAGQ LKRKITQSQD RAAPANIEEL ETKALIGSIT
DTILPKLVSN DVPVFETLLK GVFPGTDAHR IDEDNLRAKI VELAKNANYV ANDQWVEKAL
QLYQVMQLRH GVMLVGASGT GKSSAWRVLM NAMELVDGVK GEAHVIDPKA LSKEHLYGVL
DNTTLEWTDG VFTYLLRQVL NSVRGESEKR HWIIFDGDVD PEWAENLNSV LDDNRLLTLP
SGERLEIPPN VWIMMETETL RYATLATVSR CGMVWFSHDT VKTCHIVEHY LLKMRDDVSV
VSSFTLQPSE SELAKKTAHT YVTLLRDLIH REDGIPSLIE VCLEQAMGQT HIMEVTALRL
LMSMFTLLGR GLSRINEYNE GHSDFPMTVD QMSRFVPKWF VFSILWGFGG SMDSVNRMDL
CDFVVQTLEN RLVFPVSALS SPDNSLLEYE VSIDDGEWRQ WLRSIPQLDL ESHQVLSTDV
VVTTVDTIRH VEVLRGWLSQ HRPLILCGPP GSGKTMTLTS TINSLPEFEF ASLNFSSGTS
PDLILKTFSQ YCEYKRTPNG MMLSPNAPEK WLVVFCDEIN LPEADRYGTQ RVITFLRQLI
EQGGFWLGGK NNWVRLERIQ FVGACNPPTD PGRVPISLRL LRHAPVLLVD FPSYPSLKQI
YGTFNRALLK LTPSLRSYVQ PLTDAMVDVY DSNQKKFTAE MQPHYIYSPR ELSRWMRALY
EAIEPLEYEI DVETLAKLVF HEALRLFMDR LVTSDEQNWC FHMVKETLRN HFPQSATALE
VVEYGGQHPI LFSTWLSKNY TEVTTTDLRK HIEARLRVFY EEELNVQLVV FDSVIDHVLR
IDRVLRQPLG HLLLVGESGA GKTVLSRFVS WMNGMSVFQI KLTSNYTLDN FDDDLRVVLK
RCGCEAEKIC FIFDESNVLD SAFLERMNAL LASGEVPGLF EDDEYTSLMH ACREAVQRDG
VIVENTEDEL FRYFTKQVQR NLHVVFTMNP ASGDFQNRTN TSPALFNRCV VDWFGTWNDH
ALAQVAYEFT NTLDLAGSAD FVIPDDAAEV LAKLIPHIAT GTFRDVLVGS IVQFHHAVLL
HMLRLQKRHM KYNHISPRDY LEFIRHFVSL YSEKRAQLED QQLHLNVGVQ KLQATHEQVA
ELQGQLSLKE KELKKKDVEA NEKLQQMVQE QNEAQEKKKD TEALAADLAS KDEEIRSRKE
VVEADLAQAE PALLDAQSSV NSIRKAQLDE IRALARPPAA VRMTMEAVAV MLGESSLEWA
DLRRFIRKDD FISQVVNFDS EKLTARQRHT IQANYVDKVD EFDYEKVNRA SKACGPLYKW
IVSQINYTNI LHKIQPLRDE VQTLVDKSSD LRQRYEQAKH TIDALEVRIE SYKHEYAALI
NEAQVITNDM ASVSKKVGRS VALLKSLLQE SERWETGSND FDTQMKTLVG DTLLSSAFLT
YIGFLDFQQR KILVQDWRDI LDSMGISTKP QLSFVDYLSR PNEQLEWQMS DLPSDELCYE
NAIILQRFHR FPLIIDPSGQ ANNFIMKYYS LKTNTKIAQT SFLDSSFMKV LASAIRFGTA
LLVHEVENID PILNPVLNRE LYKTGGRVLI RLAGEEIDYS PDFRLFLITR DPSCRFSPDI
CSRVTFVNFT VTPSSLESQG LSILLKSEQP EAEEKRNNLL KLQGEYQAKL RELEDSLLQQ
INNVQGNILD DDRVINALES MKAEAAQISQ QVAETESTMA LVEAATSRYR PLAKASSRLF
FALENLSSVH FLYQYSLDFF LSLLSRVLAR PAEGGDLARL ASISTGLFVL LAGRVSRGLA
ENDKLMFALR LSQIYLELEQ QSAAVADAKT TMDDSSAFDG PTDEDMDMLL GSSATFLKTD
GGAQRSEFEQ LLPAFSKTEM DQLLKLMKLS TFKHLEGHVR EHAAEWNTFL KTPSAEMVLP
ADWDAEYVAS SASPRRAAFR NMIVIHFLRP DRIMFASEKY IELVFTASFP WRGEIELAKN
IDEDTQAARG VLLCSTTGFD PSAQIDELAA VLKKKYNSVS MGSSEGFDAA EKGINTALKH
GTWLLLRNVH LCPSWLVSVE KKLYNARESV HPNFRLFLTS EINPNLPVNL VRMCDIFVFE
PPSGMKLSMV RSLDTVAAER MNRTPAERAR LYLLLAWFHA LVHERLRYVP IGWSKTYEFS
QSDFRGACDV IDRWVDSVAN GRAHVAPDNI PWTAIRTTLK ESVYGGRVDN TFDQELMDTL
LEHVFTAASY ENTFELVAPG GGSDTGLVIA EGKTKAQFMD WVLALPTTNP PSWMGLPRSA
EMMVLISQGA RMLRNLQVMQ DFYGNEGGDD VAGADDESKM VLGTAGSDGE DARPKWVQDL
DHRVGAWLEL FPAEGLAVPT VRDPVHFGNP VYRCMFRELE LGAKFLGNVV GQLRTVQRVC
AYKAKPSNET RQAMRTLYRE QVPEQWKQLY RVSGDLNVSE WLSDFSRRVH QLNALAEVAP
TELLQQSGGI WLGGFFSPEA FVTAARQSAA ADLGCSLDEL HLLADVEDPS TLSPGGFSAR
GLLLEGATWN FTGFAPSNEI RNGLSALHLR WAPRNEASSD NLRLLPVYSS SKRETLLFSV
AVNAEDSAFP KTQWVQRSVA LVLWEVQA
//
