ID H3GR72_PHYRM Unreviewed; 1016 AA.
AC H3GR72;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblProtists:Phyra79353};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra79353, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra79353}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra79353};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Sulfur metabolism. {ECO:0000256|ARBA:ARBA00004678}.
CC -!- SIMILARITY: Belongs to the PPase family.
CC {ECO:0000256|ARBA:ARBA00006220}.
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DR EMBL; DS566036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3GR72; -.
DR STRING; 164328.H3GR72; -.
DR EnsemblProtists; Phyra79353; Phyra79353; Phyra79353.
DR VEuPathDB; FungiDB:PSURA_79353; -.
DR eggNOG; KOG1626; Eukaryota.
DR eggNOG; KOG4238; Eukaryota.
DR HOGENOM; CLU_009463_0_0_1; -.
DR InParanoid; H3GR72; -.
DR OMA; QGEVDHK; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004020; F:adenylylsulfate kinase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004781; F:sulfate adenylyltransferase (ATP) activity; IEA:InterPro.
DR GO; GO:0006796; P:phosphate-containing compound metabolic process; IEA:InterPro.
DR GO; GO:0000103; P:sulfate assimilation; IBA:GO_Central.
DR CDD; cd02027; APSK; 1.
DR CDD; cd00412; pyrophosphatase; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.90.80.10; Inorganic pyrophosphatase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.10.400.10; Sulfate adenylyltransferase; 1.
DR HAMAP; MF_00065; Adenylyl_sulf_kinase; 1.
DR InterPro; IPR002891; APS_kinase.
DR InterPro; IPR025980; ATP-Sase_PUA-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR008162; Pyrophosphatase.
DR InterPro; IPR036649; Pyrophosphatase_sf.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR024951; Sulfurylase_cat_dom.
DR NCBIfam; TIGR00455; apsK; 1.
DR PANTHER; PTHR11055; BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE; 1.
DR PANTHER; PTHR11055:SF1; PAPS SYNTHETASE, ISOFORM D; 1.
DR Pfam; PF01583; APS_kinase; 1.
DR Pfam; PF01747; ATP-sulfurylase; 1.
DR Pfam; PF14306; PUA_2; 1.
DR Pfam; PF00719; Pyrophosphatase; 1.
DR SUPFAM; SSF50324; Inorganic pyrophosphatase; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR PROSITE; PS00387; PPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..501
FT /note="ATP-sulfurylase PUA-like"
FT /evidence="ECO:0000259|Pfam:PF14306"
FT DOMAIN 511..717
FT /note="Sulphate adenylyltransferase catalytic"
FT /evidence="ECO:0000259|Pfam:PF01747"
SQ SEQUENCE 1016 AA; 113968 MW; A5A04D76AC39BA75 CRC64;
MSDALYASVK QEDLELNEGA ASRVFSRGPD HDERRELVKK FVLAALVVMP YLVLIALFAG
VGSPSVGSSY APSIAVSDLA NQTQVDQVCA DQRLQKLDMQ RNVYYDSSLL TRPQRYAALQ
QKGATLWFTG LSGSGKSTVG RALEKELLRR RVHTYRLDGD NVRIGLNRDL SFTETDRAES
VRRVGEMSAL FSEAGVITLV ALVSPFRARR DEVRELHKKM NIPFYEVFVD VPVSVAADRD
VKGLYKRAIK GEIKDFTGIS SPYEEPLTPE IHLNASSQSL DDEVKMILDK LEAEGLLTGV
EEPPSGYPGV AVADGGNAVA TFPTLFPDQP RSTRPGNFDE LPRVLLRDED VHWLQVIGEG
WAAPLRGFMR EGVYLQSLHF SSVLYDSDNL TDGHLALHKS TNFSEYSSEF VSKGQRVNMP
VPIVLPINDA TKDHIGEFKQ VVLVSPSGEE LALLNEPEIF DHRKEERITR TFGAMDNGHP
YIAEILKSGE YLLGGEIELL SRVKYNDDLD EYRLTPTELR KRFEEMGADV VLAFQTRNPT
HAGHAYLMNN AREQLIAQGY KNPVLWLSPL GGWTKEDDVP LDVRVRQHEA ILRDGMLDKE
STVLAIWPSP MIYAGPREVQ WHAKSRKNAG ASFFVVGRDP AGIKRSDGDK DDIYAGDHGR
FVLHMAPGME DFNILSFSKV YYDVQDHKMK PMDSSRKQDF LSISGSRMRK MAREGLQKCE
GDKIPAGWED KPTCVPQGFM VKSGWDIMID YYQNINSPRW IPFATQFSKP VVDTTRSFSS
EGTFGRTDYK LHFKNDKGEK ISPWHDIPLH PADSKDNSSY NFIVEIPKGI AHKMEVNKED
RYNPIMQDTT HNGTRGRDYL YGVPFFNYGL FPQTWEDPSV KDESGNGGDN DPLDVIEIGA
KQLAMGSVNP VKILGSLELV DQGEVDHKIL VLSLADEDAD KINSVADLQS VKPGVLDALV
DWLKKYKIPE GKSENVFSQE NPTSAEAAIQ IVQETHERWQ KLKAGEISVK DEFWLN
//
