ID H3GUG5_PHYRM Unreviewed; 3302 AA.
AC H3GUG5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Myosin-I heavy chain {ECO:0008006|Google:ProtNLM};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra80864, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra80864}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra80864};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; DS566050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 164328.H3GUG5; -.
DR EnsemblProtists; Phyra80864; Phyra80864; Phyra80864.
DR VEuPathDB; FungiDB:PSURA_80864; -.
DR eggNOG; KOG4229; Eukaryota.
DR HOGENOM; CLU_225724_0_0_1; -.
DR InParanoid; H3GUG5; -.
DR OMA; FAMENDT; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd17781; CBS_pair_MUG70_1; 3.
DR CDD; cd17782; CBS_pair_MUG70_2; 2.
DR CDD; cd14890; MYSc_Myo29; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 10.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000270; PB1_dom.
DR PANTHER; PTHR13140:SF856; HEAVY CHAIN, UNCONVENTIONAL MYOSIN; 1.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR Pfam; PF00571; CBS; 14.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00564; PB1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00116; CBS; 18.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00666; PB1; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 10.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51371; CBS; 15.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3277..3299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..766
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1277..1335
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1344..1404
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1436..1498
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1507..1565
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1616..1675
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1683..1740
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1853..1914
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 1959..2017
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2026..2083
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2317..2375
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2384..2440
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2585..2644
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2718..2778
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2786..2842
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 2884..2943
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 601..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..668
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1049..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1229..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1580..1606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2279..2311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2683..2712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3203..3273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 904..964
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1009..1036
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1056..1095
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1580..1597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2282..2301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2689..2705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3203..3224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 125..132
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 3302 AA; 362850 MW; 981DF9021BED1295 CRC64;
MTRKERLLRA KLKKKMADDD KSPSSGANSF EDILQMSDLS ELSLLENLRK RYEHALIYTY
VGSILIAINP YKQLDAYSER QMTAYYGKAM GALPPHVFAL ADHAYTQLIQ GGALDPANQS
IIISGESGSG KTETTKIIMQ YLARATSYRK GPDGEAGAPL VEPTANSGMS GALGKLEEKV
LESNPLLESF GNAKTLRNDN SSRFGKFIEI QFNHHGKIVG AQILNFLLEK TRIVSQSLGE
RNYHIFYQLL AGADNALRER LQLQTPHDYE YLRKSECFSI HECDDAKEFM TTKRCMETIG
ITGQRQEMVF ELLAAVLQLG NLQFAMENDT CVTLGDDSAD GMKLVASLLK VSEDALSKAL
LTRQLYVGGK VIVQQQNSEQ VRDKRDALAK GIYSSLFLWL VSELNRTISR TQDKWGFIGV
LDIYGFEKFE WNTFEQLCIN YANEKLQRHF NQHMLEVEQN DYAKEGIDWK HIDFEDNQEC
LDLIESKVNG KPGIFISLDD NWRLKGEEAN KKFVSNLHNS FGRTSSGHSS SKNKFYVHPK
MDADLHFGIK HYAGEVIYDA SGFNDKNNET MNDDMKELIR QSESDWLRGI FDLNMQSIEA
IPGNKPQQQH SISRRPNEMK KGLHQQGNKS RNIREVSVSA QFRYQLQELM AKISLANPRY
VRCIKPNEFK RPSELNDTDC ARQLKYSGMM EAIQIRQRGF ALREDHDVFF YDYQSLAPEA
ENIKELVEEI SSILGAGKEE WQLGKTKVFL KRTMAFKLRK LEVLRCKSAA RAIQKWVRNI
ARTEAAVKIQ TKTRQFVAKR RLQRLRRSAY RVMYILRMRV AMTKYQHLRA EYRLKSEKAV
IVQKIVRGHL VRKRDLLHPF GDLGPKELDA KIAEMETAIE AAAQSKQFEL CANLQLDLEK
IVEARKKVRT AKEIDAEIKK LNEDMEAAAM SKQFGLCAEL QKQLESLQEA RKNVKEDLNE
LEPEELDERI HAMETTIAEA MAARDFGKCG DLQISLDVLV TARKKKQTPE ELDTEIAKLN
QELDNLMQKK QFDKCAQLQK DIDVLKKKRA KFPAAAPKAP TPPPSPKKPE PPAEPTPPPS
PKKETPPPEE PAAPAPPSNM DRSGIPAREP VAAVEAPNSS PAALPGEKRP AVELPQTAPA
AQVAPVPQAS PAPLASPVVL APAQSFEEYP PAAAAPVNEY VAPQEVPTAP TPMPKRPPAI
YNGPSSVTWG ASKSSTMTPV MPPIKQPTFE RRARSGSNSS ATSGHSFARS HSSMMSTSSK
TKKSSSTVDP SRTVARLRPA KAITVNEDST VLEAARLMKS HRAAAVLVTN WEGALTGIFS
DTDAARRVVS KGVDPARVSI RSVMTPNPSC VSLEDNAVDA MDTMLSGKFR HLPVVSSHSG
NIVGLLNVAK CLHDAIRRVE NMSTSLQQEL GASSNNVLLR GMLEKMLSPS LQDVVSAPGE
VMPPLVYGNM TVYEATTYMA ETRRPALVVS SNPESQDLVG IFTPKDVLLR VIAEDLDVHT
TVVSDVMTPN PESAAPETSV LDAFHIMHDG KFLNLPVVSP DSGEILGVAD VLSISLASFG
ESRDIGKFFN AAFDYHDDDT TSMTSGRSTS NLSVASKVRQ QKDRDKGVNI RPVSSLRPLP
AVTIDEVASV FEAALLMKQK RTDALLVVDE AGGLNGILTD TDICRRVLAL NLNPEEVPVC
NVMTRDIKYV SPNDSAIDAL LSMQEGHFRH LPVVDGGGIA GVLNIGKCIY DVSKRLEHAT
QSTDQLKASL EKSGKSSTLQ QLLAPMLEKL STPTLGSILE AESQNGSTPA PRMPKSSLVS
DVAKAMASTK KAALIVDDFN FDKLVGIFTP NELVMNVIAK SLKPSATYVE EVMLNDPEIA
APSTSVLDGL HIMHDSRCLN LPVLKEDSYE LVGMVDVLDL SYGTIDAIYG ENREQMQEFW
NTTLQLDQPS LPSEAGDRER TTLLSRAEQE EKKRTVSKLR PTKVLTVSET TTIAELSRTM
GRNKMDCVLV VSEEGMLNGI ITDTDLTRRV VSENRPLDST LVGDVMTRNP VFVSMDDPAI
DALISMLEGK FRHLPVVERN GPVVGILNIA KCLYDAIRKM EKSEQSSAAL RHTLEKEMKS
RVNGNARTGG VSQLLGSMVN KMFSPDIKTV IEEEGVDPPR VQRFTSVFEV SKQMAITKKG
ALVVNNRGQF CGIFTPKEML EKVLARGLPV HTTPVCEVML EKDVTVNGAT SVIDAMHTMH
DYKTLYLAVM QSEVNKQPIG LIDVLSLSYG SFAKGKPSEW KSFWNASFEA TDDDDVSSHH
SFRSGLSHNH AASSTGMSQK DKKPSLAKGD VRPVSKLRPS KAITISETFS VADAAKEMSV
AQTDAALIIG RDGGLLGILT DTDVTRRVVA LGNDPFYVSV LDAMTPDPKF VDERDSAMDA
MFMMLEGKFR HLPVVDETGM VAGMLRIQKC LYDAITRIEK VQQSSSGSLR QRLEKQLHAT
GIGSGQGALK QLVAPMVDKL LSPTVDSILE DETLPPLVSE HDTVMEVARQ MAASRKAALI
VEDPNADNSS SVSGGHRSSI SGGGYDIGTS ALTRKVLGVF TPKDLLLRVT GAGLDAAETT
VGQVMTPNPE TAPPSTKLVE ALHIMYEHNF LHLPIVNPET STIVGMLDVL SLCYGTFASG
AAAESGSPID EDSDWRAFWD VSLALGHDDD DFSELASMTG SRYSRMSRRR PGKYTESHHS
SMMDHVPEPE GAMRPVSMLR PQEVTRINEF ITVAEAAKRM RQARVEAVVV TTEEGELRGI
LTDTDITRRV LAEDIDPESC SVASVMTTKP TCVFMEDQAI EAITKMLEGR FKHLPVLASD
GTPQGMLDIS KCLYDAITCL EKVQQSTEAA ASEFSRDLGT GSNLQRLLGP MMEKMVRPTV
GDALDGELMP PVIDIHTTAA RAAKLMSNTK KAAIVLGDEH ELCGMVTTKD LLRKLVAKGL
YAETTTVEEV MTMDPDLMGP EMSIVDGLRA LHDAGQLFMP VLADDGEILG MADVICLSYG
QFQTTSGGTS NGDWRQFWQT AMNLQEEVAG GAYGGLNDDV RSVGTIEEFE RDEYNADSVS
TPTASAVGLN GAGRYSNSLG AYAELGESVS VVSGANTATT SVMMKNITDE NTFVFKVSDG
PQGHFHRIMC RFNSMGPLLE QIRFKMGLDD NEALRLRYED DEGDMALLTS DESLVEAVHM
AQRAGWKRLV LELDVVKRQQ HDGNGSVVSM ASSAAGSATG SNVAGPKPRN RLLTKVDELS
SSDSSDDSSS EEEVVRKKSK KSRRKNRDRG FSLNSNAGLI AGGAATLVVG LSAVALMFMR
RK
//
