ID   H3H521_PHYRM            Unreviewed;       558 AA.
AC   H3H521;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
OS   Phytophthora ramorum (Sudden oak death agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra85701, ECO:0000313|Proteomes:UP000005238};
RN   [1] {ECO:0000313|Proteomes:UP000005238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX   PubMed=16946064; DOI=10.1126/science.1128796;
RA   Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA   Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA   Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA   Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA   Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA   McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA   Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA   Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA   Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA   Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT   "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT   of pathogenesis.";
RL   Science 313:1261-1266(2006).
RN   [2] {ECO:0000313|EnsemblProtists:Phyra85701}
RP   IDENTIFICATION.
RC   STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra85701};
RG   EnsemblProtists;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; DS566279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H3H521; -.
DR   STRING; 164328.H3H521; -.
DR   EnsemblProtists; Phyra85701; Phyra85701; Phyra85701.
DR   eggNOG; ENOG502QSNP; Eukaryota.
DR   HOGENOM; CLU_488771_0_0_1; -.
DR   InParanoid; H3H521; -.
DR   Proteomes; UP000005238; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR   GO; GO:0001881; P:receptor recycling; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR045188; Boi1/Boi2-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR22902:SF27; INOSITOL PHOSPHATASE INTERACTING PROTEIN, ISOFORM A; 1.
DR   PANTHER; PTHR22902; SESQUIPEDALIAN; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005238}.
FT   DOMAIN          58..178
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          349..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          516..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..47
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   558 AA;  61706 MW;  CCADF2458B439310 CRC64;
     MADKKHDDNS TGSPGTIGAN TELQRHEDES TDRGQNDDEE EEEEAAVNSI TDSVAHLAPE
     KTGWLKKKKR KQHGLGSSWQ PRYFELKGNR LYYFASEADG LPRGAVLLDH ALVQRGRGDQ
     AMAFSISSGS SHRRLQVLKF SARLTQQVFP RKSIELRVVE ETEAAVSAWA EALNRASFYC
     KLAAATAGSS STLPAHSSSS FGPFSTPDKK RKTPFYRFRS PTATKAAMAS SSLSLSAEKE
     RQDVEYADAE ELRTTTARWT ASYQQLGSVQ YLRETDPLLW EIHPPEQIAI RKKAARAKTR
     GDYLAIFSRH AETFAQIFLP RPQPISLEQT LRDILPELFL INDTLYGGGE QQQQQQSPEQ
     SGGDSSGQQQ QQNRGLEHIF EVLDVHIQRF AAASEERVRA VSALLQACAR TISGGDSYFV
     VHRLLGNPNL IIRPAEARGR PIEIDVSPEH PSRFLITVFS AFSFHLLDDV ERFGDSNDAS
     GGGMTPAPLL RVRTRHIQEF DFASGTSTRW LRIDVEGRKE DNSPGSGGGG GGSLRWGSRR
     QSHEAAESRI GALLDALS
//