ID H3H640_PHYRM Unreviewed; 671 AA.
AC H3H640;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 4.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Integrase catalytic domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Phytophthora ramorum (Sudden oak death agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=164328 {ECO:0000313|EnsemblProtists:Phyra86131, ECO:0000313|Proteomes:UP000005238};
RN [1] {ECO:0000313|Proteomes:UP000005238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pr102 {ECO:0000313|Proteomes:UP000005238};
RX PubMed=16946064; DOI=10.1126/science.1128796;
RA Tyler B.M., Tripathy S., Zhang X., Dehal P., Jiang R.H., Aerts A.,
RA Arredondo F.D., Baxter L., Bensasson D., Beynon J.L., Chapman J.,
RA Damasceno C.M., Dorrance A.E., Dou D., Dickerman A.W., Dubchak I.L.,
RA Garbelotto M., Gijzen M., Gordon S.G., Govers F., Grunwald N.J., Huang W.,
RA Ivors K.L., Jones R.W., Kamoun S., Krampis K., Lamour K.H., Lee M.K.,
RA McDonald W.H., Medina M., Meijer H.J., Nordberg E.K., Maclean D.J.,
RA Ospina-Giraldo M.D., Morris P.F., Phuntumart V., Putnam N.H., Rash S.,
RA Rose J.K., Sakihama Y., Salamov A.A., Savidor A., Scheuring C.F.,
RA Smith B.M., Sobral B.W., Terry A., Torto-Alalibo T.A., Win J., Xu Z.,
RA Zhang H., Grigoriev I.V., Rokhsar D.S., Boore J.L.;
RT "Phytophthora genome sequences uncover evolutionary origins and mechanisms
RT of pathogenesis.";
RL Science 313:1261-1266(2006).
RN [2] {ECO:0000313|EnsemblProtists:Phyra86131}
RP IDENTIFICATION.
RC STRAIN=Pr102 {ECO:0000313|EnsemblProtists:Phyra86131};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; DS566470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3H640; -.
DR EnsemblProtists; Phyra86131; Phyra86131; Phyra86131.
DR VEuPathDB; FungiDB:PSURA_86131; -.
DR eggNOG; KOG0017; Eukaryota.
DR InParanoid; H3H640; -.
DR OMA; ARQITHI; -.
DR Proteomes; UP000005238; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR025724; GAG-pre-integrase_dom.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR42648:SF18; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR42648; TRANSPOSASE, PUTATIVE-RELATED; 1.
DR Pfam; PF13976; gag_pre-integrs; 1.
DR Pfam; PF14223; Retrotran_gag_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000005238};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 113..128
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 361..534
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 76..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..645
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..661
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 74885 MW; AAD02F8FDC9FFEE0 CRC64;
MMDEGDDVLE HINKLKTLAE QLDAVGAPVS EDDLVITLLG SLSESYQFLI TALESRADSL
SWELVTSRLL HEDMKRKEQG GGGVDGAAHG QGQAFMTRDN KRKGRPVKKT GACHNCGKQG
HWIAECPSRV HNDAERYRSQ RANVAQDEED PGDYLFSVGR TSSAAKPSDM WLVDSGATQH
MTSSSKYMRN YKKMAPVDVH LADDGVVQAV GTGDIVMSMK TPRGMKKGVL TNVWHIPKLS
RNLFSVGRFT KDVGPVTFES DGCFVDNKGL KWQLGAREGK GLFKLCMTPM MPDEANAASS
KDRQGDTTSY LWHLRLGHIG HGGLDAIVKK SYGVGIDMTS VKQWELCDGC ALGKQTRVSY
MKSSPNRAKQ VLEVVHSDVC GPMQTPTFGG KRYFVTFIDD KSHFCVVYLL RNKSEVAAKF
AEFVAFAETQ TGKRVQTLRS DNGGEYTSGV MAKFCADRGI VQKFTPPYTP QLNGVAERMN
RTLVECARCM LEHAGLPKTY WGEAVMTATF LRNRCPTRAI GHDKSPHQVW TGKKPLLANL
KVFGCHAYVH VPKAKRTKFD ARSVRCRFLG YSEHEKAYRF EELESSRVLV SRDAQFMEDV
FDSGRRDYHQ REVVVIQDEE TTDQDSSQSD EDDNEEEEEE EAARDEDFGP GNKRHPRTQS
LEEATEVPSA K
//
