ID H3NI87_9LACT Unreviewed; 602 AA.
AC H3NI87;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Oligoendopeptidase F {ECO:0000256|RuleBase:RU368091};
DE EC=3.4.24.- {ECO:0000256|RuleBase:RU368091};
GN ORFNames=HMPREF9708_00515 {ECO:0000313|EMBL:EHR37886.1};
OS Facklamia languida CCUG 37842.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Aerococcaceae; Facklamia.
OX NCBI_TaxID=883113 {ECO:0000313|EMBL:EHR37886.1, ECO:0000313|Proteomes:UP000006190};
RN [1] {ECO:0000313|EMBL:EHR37886.1, ECO:0000313|Proteomes:UP000006190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 37842 {ECO:0000313|EMBL:EHR37886.1,
RC ECO:0000313|Proteomes:UP000006190};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Heiman D., Howarth C., Larimer J., Lui A.,
RA MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P., Stolte C.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Facklamia languida CCUG 37842.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has oligopeptidase activity and degrades a variety of small
CC bioactive peptides. {ECO:0000256|RuleBase:RU368091}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU368091};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU368091};
CC -!- SIMILARITY: Belongs to the peptidase M3B family.
CC {ECO:0000256|RuleBase:RU368091}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHR37886.1}.
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DR EMBL; AGEG01000003; EHR37886.1; -; Genomic_DNA.
DR RefSeq; WP_006308542.1; NZ_JH601133.1.
DR AlphaFoldDB; H3NI87; -.
DR STRING; 883113.HMPREF9708_00515; -.
DR PATRIC; fig|883113.3.peg.517; -.
DR eggNOG; COG1164; Bacteria.
DR HOGENOM; CLU_021290_1_1_9; -.
DR OrthoDB; 9766487at2; -.
DR Proteomes; UP000006190; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1370.20; Oligoendopeptidase f, C-terminal domain; 1.
DR Gene3D; 1.20.140.70; Oligopeptidase f, N-terminal domain; 1.
DR InterPro; IPR013647; OligopepF_N_dom.
DR InterPro; IPR042088; OligoPept_F_C.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR InterPro; IPR004438; Peptidase_M3B.
DR NCBIfam; TIGR00181; pepF; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR Pfam; PF08439; Peptidase_M3_N; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU368091};
KW Metal-binding {ECO:0000256|RuleBase:RU368091};
KW Metalloprotease {ECO:0000256|RuleBase:RU368091};
KW Protease {ECO:0000256|RuleBase:RU368091};
KW Reference proteome {ECO:0000313|Proteomes:UP000006190};
KW Zinc {ECO:0000256|RuleBase:RU368091}.
FT DOMAIN 113..181
FT /note="Oligopeptidase F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08439"
FT DOMAIN 208..583
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 602 AA; 68581 MW; A4F407126F3B1FB5 CRC64;
MSNLPLRNEV PVDHTWDLSL LFSSQEAFEE AILNYHELLE TIQTYKGKLI NAEEIIDALS
LYEKIITDFS KISHYGELAY EVDKLDPLKE ENNASVRNLR NKTGAATAFI RVEIAENNIE
LLQSVMDSDE GKGYRVYIQD IIDHKDHILS EEMETFLGFV SSELFNQYQI YNTLMYQDLS
FADFSAGGKT YSNSFAGFEG EYEVDLKAEV RHNAWKSFHA GLSKYQNTAA INYISHTQTE
KKLSLERGYE SVFDYLLADQ GIDRSTYDKH IDLLMTEFAP VMQRYARLLK EKHGLDTMSL
ADIKIPYSTD SGHNLSISEG EEIVKKALSV YGPDYNAYVD RAFNERWIDF PMNQTKTTGG
FSTTVPGGPS YVLLNWTGYL SEALVLAHEL GHSSHFQLTY QNQSVLSPEV SLYFVEAPST
CNEVITCQYL LNGDLSHEDK IGLIGEFISR TYFHNMVTHL LEADFQRKVY QAVDRFENLN
ADKLNRFFYD TLKKFWGDAL EINEGAELTW MRQPHYFMGL YSYTYSAGLT IGTQVGLKIA
NQDQEVIENW LTALKAGSSL NPLELTNYVG VDMSTPDALR ATIQYVSSLV DHLEEDCNMT
NA
//
