ID   H3NUD1_9GAMM            Unreviewed;       351 AA.
AC   H3NUD1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=cysteine synthase {ECO:0000256|ARBA:ARBA00012681};
DE            EC=2.5.1.47 {ECO:0000256|ARBA:ARBA00012681};
GN   ORFNames=OMB55_00021160 {ECO:0000313|EMBL:EHQ58369.1};
OS   gamma proteobacterium HIMB55.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae.
OX   NCBI_TaxID=745014 {ECO:0000313|EMBL:EHQ58369.1, ECO:0000313|Proteomes:UP000003408};
RN   [1] {ECO:0000313|EMBL:EHQ58369.1, ECO:0000313|Proteomes:UP000003408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HIMB55 {ECO:0000313|EMBL:EHQ58369.1,
RC   ECO:0000313|Proteomes:UP000003408};
RX   PubMed=22493201; DOI=10.1128/JB.00171-12;
RA   Huggett M.J., Rappe M.S.;
RT   "Genome Sequence of Strain HIMB55, a Novel Marine Gammaproteobacterium of
RT   the OM60/NOR5 Clade.";
RL   J. Bacteriol. 194:2393-2394(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine;
CC         Xref=Rhea:RHEA:14829, ChEBI:CHEBI:29919, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:35235, ChEBI:CHEBI:58340; EC=2.5.1.47;
CC         Evidence={ECO:0000256|ARBA:ARBA00000298};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHQ58369.1}.
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DR   EMBL; AGIF02000001; EHQ58369.1; -; Genomic_DNA.
DR   AlphaFoldDB; H3NUD1; -.
DR   STRING; 745014.OMB55_00021160; -.
DR   PATRIC; fig|745014.4.peg.2143; -.
DR   eggNOG; COG0031; Bacteria.
DR   OrthoDB; 9805733at2; -.
DR   Proteomes; UP000003408; Unassembled WGS sequence.
DR   GO; GO:1901605; P:alpha-amino acid metabolic process; IEA:UniProt.
DR   CDD; cd01561; CBS_like; 1.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   InterPro; IPR001926; TrpB-like_PALP.
DR   InterPro; IPR036052; TrpB-like_PALP_sf.
DR   PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR   PANTHER; PTHR10314:SF253; CYSTEINE SYNTHASE 1; 1.
DR   Pfam; PF00291; PALP; 1.
DR   SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE   4: Predicted;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003408}.
FT   DOMAIN          18..321
FT                   /note="Tryptophan synthase beta chain-like PALP"
FT                   /evidence="ECO:0000259|Pfam:PF00291"
SQ   SEQUENCE   351 AA;  37927 MW;  4958BFDA15ED28E2 CRC64;
     MTIYSTSGRG VRYNSIVETV GDTPCVRLNR TGPSHVSMYV KVESFNPLAS VKDRLALNII
     EAAERDGTLK PGQTVVEATS GNTGIGLAMV CAAKGYPLVI TMAESFSIER RRLMRFLGAK
     VVLTPKEERG IGMYNAAKKL AEDNGWFFAR QFENAANADI HESTTAREIL ADFKDTSLDY
     WVTGYGTGGT VTGVARVLRA ERPDCTIVLS EPHNATLIGS GVAQERNDDD SPKGSHPAWE
     PHVIQGWTPD FIPKVLQEGI DRAFFDEVRP VDGTKGMAMA QHLAANEGIL TGVSGGSTLL
     TAIEVAESAP EGSVILVMLP DTGERYLSTP LFESIPAEMN DEEQALFAST R
//