ID H3NY12_9GAMM Unreviewed; 2180 AA.
AC H3NY12;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Subtilisin-like serine protease {ECO:0000313|EMBL:EHQ56736.1};
GN ORFNames=OMB55_00004530 {ECO:0000313|EMBL:EHQ56736.1};
OS gamma proteobacterium HIMB55.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae.
OX NCBI_TaxID=745014 {ECO:0000313|EMBL:EHQ56736.1, ECO:0000313|Proteomes:UP000003408};
RN [1] {ECO:0000313|EMBL:EHQ56736.1, ECO:0000313|Proteomes:UP000003408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HIMB55 {ECO:0000313|EMBL:EHQ56736.1,
RC ECO:0000313|Proteomes:UP000003408};
RX PubMed=22493201; DOI=10.1128/JB.00171-12;
RA Huggett M.J., Rappe M.S.;
RT "Genome Sequence of Strain HIMB55, a Novel Marine Gammaproteobacterium of
RT the OM60/NOR5 Clade.";
RL J. Bacteriol. 194:2393-2394(2012).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHQ56736.1}.
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DR EMBL; AGIF02000001; EHQ56736.1; -; Genomic_DNA.
DR STRING; 745014.OMB55_00004530; -.
DR PATRIC; fig|745014.4.peg.454; -.
DR eggNOG; COG1404; Bacteria.
DR OrthoDB; 9795680at2; -.
DR Proteomes; UP000003408; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd14256; Dockerin_I; 1.
DR CDD; cd00102; IPT; 1.
DR CDD; cd07473; Peptidases_S8_Subtilisin_like; 1.
DR Gene3D; 2.60.40.680; -; 1.
DR Gene3D; 1.10.1330.10; Dockerin domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008965; CBM2/CBM3_carb-bd_dom_sf.
DR InterPro; IPR036439; Dockerin_dom_sf.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034204; PfSUB1-like_cat_dom.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF01833; TIG; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF49384; Carbohydrate-binding domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000003408};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..2180
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003591448"
FT DOMAIN 1580..1663
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT REGION 2083..2156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2130..2151
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 263
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 323
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 496
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 2180 AA; 234577 MW; 3291210275E5C4AF CRC64;
MRYLKLIPVG LMIAALSYAQ EPEDVSGSET AAAKSDRVIS EPDFHVLKRQ RSFRGPYTDQ
DDPLLLAEQS KENARTGVNP NELSCRPPHC SREDARLIIK LATPASAQAL AKATGNSSKQ
SAYFVDTSLT PIFSQSQVTK ARAKLVSTRT KMPLNSMGKP VDLMRWRSLA LPAGTDLDEA
IADLSLDPRV EVVESSFERQ LKGELSKPGE DSSMSTLAVV ANDPRKGEQW ALERTRTEDA
WQWLEDNGYP AWGDRNIVVA VIDSGVDYTH EDLAGNMWVN AGEIPGNGID DDNNGFVDDV
YGADVVGQEG QDHDGDPQDD NGHGTHVAGI IAAQGNNDIG IIGVAPNAQI MAIKAAQYSG
VLTSTDISEA ILYAYQQGAD IINMSFGGSG RSVLEEEALA VAFSNAVLVA AAGNQGIYND
RNCGIFARPS YPAAYPYVLG VMAESQFVAA NGDWLAGFSN WDCKARNGLE YEVMAPGVDV
LSTIPGNGYA AWDGTSMAAP VAAGMAALVR TRFDDKSVYS SRFIMGQVAS TGASKQGNTP
CRGCLPKSYL SADALTALTE VPEPSLSYLK HYLFDETDRA GNDGDGIVDA GETIDLALII
KNYWGMADNV EVTLEAQAAG AVAGPDPYVT WDVPTVNYGG VGSFNEDDNG LIYDDEQYIT
GVNSPFRFTV AADTPNEHII PMLVTMTATN GLDPNDTSTY TTTSRFNLIV QRGRELPRVI
DSDAPGTDGG QIDTDGVEDG VVTIDDSTLW LIDNPVLIAE DTTLKVGPGA TLQFWGTQPD
DTYAVFENPY LQVEGTLDVE GTVEKPAVFK PSDLFPDRAV VIDNRSIVRI RHAELYNLSR
QQQVTGYQNY NFDLIDHSLV TRVALDGWLV VRRSESGYFS TNPGVTFGVS TLSNSRLNRL
GNELPYAREI DNVVTQSTGP AQFFMGGYGW EQALVWERAE TSLFDGTYLN SSQYQYRFLP
ELRSSVLLNN NQSWVNRYGE TVTQGSRGQL PPYALSSRSL VLTTSQIDDR TYALIVMANP
NQQLPYSSWE SKALAFNEFA SSLGGSLLVY SSDDERDKVQ SWLAGYWNRL DTETSEQLLD
LCGDNLAFCQ WMKGQKWDAN QFAYGVYRDE NGWGWITGEE PELTGYDPTK DANIIENSDA
RFVLGYACCT QSYNFASPKL ALVELPSLLT QLEVQSELDE WIEARPSAVS GNAILNQWWD
PVPNHWMVIE TPNKYDDFGL FSDSVDMTGV FWGTQSEELI RNAVRSYQTD FNKLPATIFP
AATTPSDSAY PFVVDVDIKD SDGNARADSR FASEGTVWDV TFNRDMDASV QPMVTFGPDV
PYTDFTVPGD WIDARTWRGE VTISPVATDG YQYVRVAGAV AADDPGLVTG NDQKRFRFEV
ITSGTESLNL QASGGEGYVD LSWNQDDYDT LMGFNIYRST SQDGNYVRIN QTLVGNEDRE
YRDSNTEPGV QYFYYFTVAL DGSESEPSNK ASATPIDTVK PVMSHNIIST ATFGSTVMVQ
ANVTDNISVQ SVTLYYRAIG DTTYTSVDMV NTSGSTYRAS IPASATQPPG VEYYIAATDG
SSYTYNGRAS SPNKITVENN PVVTSVSPSA GSTAGGEVIS VSGNNFVDGA TVALGSATCQ
NVVWASESRL TCTTPASAPN LVAVTVENPD GGKGVLTSAF TFVGNSTTMA LPDITASQGQ
TRDVALTVDP VSGMQSFTAV ISWNGDHLQY AGFTKGALVS GWDVVSQLEG TTLTIAGSSS
TSVSGSGELV LLEFGVVADG DVSSVIDLVS AQINEGYIET ALVDGSFTTA AGFSISGQVR
FWDASNTAVA ASVTLDNTLE ETSDEATGHF QFSGVLDGTH TLNIGKEDGI NDSIRGYDAS
LILSHVVGSA TLTGSALAAA DVTGNGEISA LDASKVLEVA AGLETVPFAN QASPWTFEPA
ERRYDEVTSN ITDADFTAIY MGDVSGNWGE LSTQSSTGVR LELDSITREG IATVNVLAAP
PVEGTAISSV ELTLNTTAGV SLIQASRTPS TNNWSEPLVT VGDNAFSAII YDDVSGAFST
ETHVLSLELS LTNGQQAVTS MGGWLNEMQL YSSEAFALKS ANDTDGDFVD DDEDAFPNDP
AASTDTDGDG MPDDWNPGYT ARDSESGLVL DLDDDNDGYS DKEEEEADTD SLNAADQPIS
GMSILLIKQA IDSAAARSQQ
//
