ID H5V896_DROME Unreviewed; 643 AA.
AC H5V896;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=FI18652p1 {ECO:0000313|EMBL:AFA28438.1};
GN Name=EloA-RA {ECO:0000313|EMBL:AFA28438.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AFA28438.1};
RN [1] {ECO:0000313|EMBL:AFA28438.1}
RP NUCLEOTIDE SEQUENCE.
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00649}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BT133197; AFA28438.1; -; mRNA.
DR RefSeq; NP_732846.1; NM_170061.3.
DR AlphaFoldDB; H5V896; -.
DR SMR; H5V896; -.
DR DNASU; 42749; -.
DR EnsemblMetazoa; FBtr0084374; FBpp0083766; FBgn0039066.
DR GeneID; 42749; -.
DR KEGG; dme:Dmel_CG6755; -.
DR CTD; 6924; -.
DR VEuPathDB; VectorBase:FBgn0039066; -.
DR HOGENOM; CLU_021679_1_0_1; -.
DR OMA; RKHEFVG; -.
DR OrthoDB; 4793at2759; -.
DR PhylomeDB; H5V896; -.
DR BioGRID-ORCS; 42749; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 42749; -.
DR Bgee; FBgn0039066; Expressed in cleaving embryo and 43 other cell types or tissues.
DR ExpressionAtlas; H5V896; baseline and differential.
DR GO; GO:0070449; C:elongin complex; IEA:InterPro.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR Gene3D; 6.10.250.3180; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR010684; RNA_pol_II_trans_fac_SIII_A.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15141; TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3; 1.
DR PANTHER; PTHR15141:SF76; TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3; 1.
DR Pfam; PF06881; Elongin_A; 1.
DR Pfam; PF08711; Med26; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 2: Evidence at transcript level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}.
FT DOMAIN 9..82
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 86..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 643 AA; 71162 MW; 45A28A4BBC5F9B57 CRC64;
MASTSNLLDV VRHYQRSIEK HGEDEQRLLH CITKLFNLPI KFEHLQETGI GKTVNALRKI
SGEVGVAAKT LVTKWKAMVA KEDPSIASTP TAIHNEEDSG KTKSSDEDPD QENKGGNSSS
GEDLNTSKHK SKHAKSTKHE RSSSSRSHSK SRSDSDKKHK SSRHDKSKDR DKDREGQKEA
KEHKEKKSNG EHKSKDSSKS SSSHKSSKSE SHKSEHTKSK HEKDKTSHSE LKEVKDKSSK
HKSSSSKSSK RSHSPPRHEE ESQKAKIPKV KSKSEEDSAD GFDSSMGANF DDVLGLLNIP
ISSKKSSSNS KSKFVAKPTA APSSSALSAP TTAGSSKEAL STSSRPTSKK PELLASTAKL
EPLDPNIALE LPTISNNYKP MPLNQTVMDV VFNQGGSHKA QASRYFNESE ALAQGISSKT
MRTKIYSGVR TGQILQVPSL FDLCTRVLQK NIDALEYTGG VPFEVLRPVL ERATPQQLLN
FEEYNPYLMD DSDVLWQQHV QRHCRSQRRE EMETWREMFL RCQEEKDRKL SILAESIKAS
QKISEAPVRK TQLAFVDSMV KPPRSVQRKQ EQYGTKGKLI ATPAARVAAL SSVTPNAAKV
GDARLRVLAA ARDTAQVGAG PARSKKAPLM AKTLQFMRGR LKR
//
