ID H5WY19_9PSEU Unreviewed; 366 AA.
AC H5WY19;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Mycothiol-dependent formaldehyde dehydrogenase {ECO:0000313|EMBL:EHR52886.1};
GN ORFNames=SacmaDRAFT_4712 {ECO:0000313|EMBL:EHR52886.1};
OS Saccharomonospora marina XMU15.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharomonospora.
OX NCBI_TaxID=882083 {ECO:0000313|EMBL:EHR52886.1, ECO:0000313|Proteomes:UP000004926};
RN [1] {ECO:0000313|EMBL:EHR52886.1, ECO:0000313|Proteomes:UP000004926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XMU15 {ECO:0000313|EMBL:EHR52886.1,
RC ECO:0000313|Proteomes:UP000004926};
RX PubMed=22768369; DOI=10.4056/sigs.2655905;
RA Klenk H.P., Lu M., Lucas S., Lapidus A., Copeland A., Pitluck S.,
RA Goodwin L.A., Han C., Tapia R., Brambilla E.M., Potter G., Land M.,
RA Ivanova N., Rohde M., Goker M., Detter J.C., Li W.J., Kyrpides N.C.,
RA Woyke T.;
RT "Genome sequence of the ocean sediment bacterium Saccharomonospora marina
RT type strain (XMU15(T)).";
RL Stand. Genomic Sci. 6:265-275(2012).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CM001439; EHR52886.1; -; Genomic_DNA.
DR RefSeq; WP_009156264.1; NZ_CM001439.1.
DR AlphaFoldDB; H5WY19; -.
DR STRING; 882083.SacmaDRAFT_4712; -.
DR eggNOG; COG1062; Bacteria.
DR HOGENOM; CLU_026673_14_1_11; -.
DR OrthoDB; 3265141at2; -.
DR Proteomes; UP000004926; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08279; Zn_ADH_class_III; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR017816; MycoS_dep_FDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR NCBIfam; TIGR03451; mycoS_dep_FDH; 1.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF12; ALCOHOL DEHYDROGENASE CLASS-3; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000004926};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 14..363
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 366 AA; 38804 MW; C6E17A6E9DB7F8AD CRC64;
MPYEVQGVVA RAKGQPVSLE TVLVPDPGPG EAVVSVKACG VCHTDLHYRE GGINDDFPFL
LGHEAAGYVE QVGEGVTDLR PGDFVVLNWR AVCGTCRACK RGKPWYCFQT HNASRPMTLA
DGTKLSPALG IGAFLEKTLV HSGQCTKVNP AAEPEVAGLL GCGVMAGIGA SINTGAVTRG
DTVAVIGCGG VGDAAIAGAH LAGARTIVAV DTDDRKLEWA KGFGATDTIN ARGKSHDEMV
EAVRELTDSF GADVVIDAVG IPQTWKQAFY ARDLAGTVVL VGVPTPDMKL DDMPLIDFFA
RGGSLKSSWY GDCLPSRDFP MLVDLYLQGR LPLDKFVTER IGVADVEQAF ERMHNGEVLR
SVVVFD
//
