ID H6BM93_EXODN Unreviewed; 684 AA.
AC H6BM93;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=polynucleotide adenylyltransferase {ECO:0000256|ARBA:ARBA00012388};
DE EC=2.7.7.19 {ECO:0000256|ARBA:ARBA00012388};
GN ORFNames=HMPREF1120_01175 {ECO:0000313|EMBL:EHY52974.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY52974.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY52974.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY52974.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B-like family.
CC {ECO:0000256|ARBA:ARBA00008593}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH226130; EHY52974.1; -; Genomic_DNA.
DR RefSeq; XP_009153435.1; XM_009155187.1.
DR AlphaFoldDB; H6BM93; -.
DR STRING; 858893.H6BM93; -.
DR GeneID; 20305814; -.
DR VEuPathDB; FungiDB:HMPREF1120_01175; -.
DR eggNOG; KOG1906; Eukaryota.
DR HOGENOM; CLU_013572_2_1_1; -.
DR InParanoid; H6BM93; -.
DR OMA; IPEHHLG; -.
DR OrthoDB; 21395at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProt.
DR CDD; cd05402; NT_PAP_TUTase; 1.
DR Gene3D; 1.10.1410.10; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002058; PAP_assoc.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR InterPro; IPR045862; Trf4-like.
DR PANTHER; PTHR23092:SF15; INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED; 1.
DR PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR Pfam; PF03828; PAP_assoc; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007304}.
FT DOMAIN 272..363
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 434..492
FT /note="PAP-associated"
FT /evidence="ECO:0000259|Pfam:PF03828"
FT REGION 1..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..156
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 74575 MW; 1319210E5693132B CRC64;
MTDSDEEAMA LSEDEEHERN TKRARTGEPA TTVDPSPAPK WSNPDPYTAL PPPATTEGTA
KRTDVLKLIR KARIESSRNP GLVASADDFI SFEADEPHAE DSGPILPPPE SPPPPPSDSI
PLPSSDSIPP PPSEPIPPPP SDSIPLPPPD SIPPTPLDSP QDRSVDVEVA EESAAVPEDK
VLGKRKRGQT IGSQSPGRAS RNKASGDVMV QQRWAVVQGV NPAPWLTASD GTDIPGIALH
KEIIDFYHWI KPKAYEQQVR DSVFQRLSSD LQKCMPGELK AFGSYAAGLY LPTGDMDLVY
FTRGYRRGQL PTKDEGRRLL SIFAKFLRTK NMAKPGSVIT IPFAKVPIIK FVDRISGLKV
DLCFDNDSGV AAVETFQKWK KEYPAMPIIV AIVKQFLMIR GLNDVATGGL GGFSTICLVT
SLLQHMPPTK QRLNLGEVLL EFFNLYGNVF DKNSVGIRLD PPAYVDKSSY MPYAFKDKDG
RLTIVDPNRP DNNISGGTRL IDNIMACFSS AHRTLLDQLN EYEQRVLHGQ PQSLLECLIG
GNFTLYETQR QTLLNLSTAS TNVPLATAGH LPPPHPLVVN AAVPGPKKGK NKPSGGAQKE
SDTKMQDAPS SSESLQTPTS KKLSKGERRA NRLRRLRPEL ASSIGKTISR QQAVTLGGYK
TPEAMERDLQ SREAASQKAA AKAK
//
