ID   H6BRV9_EXODN            Unreviewed;       715 AA.
AC   H6BRV9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Esterase/lipase {ECO:0000313|EMBL:EHY54787.1};
GN   ORFNames=HMPREF1120_02951 {ECO:0000313|EMBL:EHY54787.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS   yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY54787.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|EMBL:EHY54787.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY54787.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; JH226131; EHY54787.1; -; Genomic_DNA.
DR   RefSeq; XP_009155248.1; XM_009157000.1.
DR   AlphaFoldDB; H6BRV9; -.
DR   STRING; 858893.H6BRV9; -.
DR   GeneID; 20307590; -.
DR   VEuPathDB; FungiDB:HMPREF1120_02951; -.
DR   eggNOG; KOG4388; Eukaryota.
DR   HOGENOM; CLU_003590_1_0_1; -.
DR   InParanoid; H6BRV9; -.
DR   OMA; NMYDATY; -.
DR   OrthoDB; 37251at2759; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013094; AB_hydrolase_3.
DR   PANTHER; PTHR23025:SF3; HORMONE-SENSITIVE LIPASE; 1.
DR   PANTHER; PTHR23025; TRIACYLGLYCEROL LIPASE; 1.
DR   Pfam; PF07859; Abhydrolase_3; 2.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304}.
FT   DOMAIN          219..345
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   DOMAIN          451..523
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   REGION          372..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..695
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..395
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        407..422
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        646..663
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        665..684
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  80764 MW;  8436FE6633E74217 CRC64;
     MIDHVLGRPS SQFRKVQVFA VVSFWSLYLL RGHRHGPVGL RKLSERLSQR LTPWRSVVLT
     LLWLYICRNF AKIFNLESPE PLANLYSRSY FRATWITTAL DAGFWTAMRI RNKRIRDLAS
     IIFTVYYLIA AEQADEKVRK VRAVLTVDHL RVSWNKPNTP YLKWLTAMLR PRFIKYKPRR
     IRIPRPKQSH YKEPVVAWMY FDGSLAELEK QENLVLDIPG GGFVAMDPRT SDDKLLAWAG
     KTGLPVLSLD YRKAPEFPYP YALNECFDVY TQIVATRGRC IGMKPDSCPR IVITGDSAGG
     NLATGTTLMI IQSNQTGTSR GILPSPAGLV LLYPALDMNI GSWMTDDQMA LIRNPRTAKK
     YRSFIKRKSE DIDRRYTPTT PRPADDDDDE GGPGHDFFAS RGSTSTDKGK GKARDDPPDV
     DVEAQKQAVA TSKPQPLKTR LAVSSIISYF GDRILTPEMM RAMIILYVGP YNRPDFTTDH
     LLCPAVAPEN LLAKFPKTYL LTGERDPLVD DTVIFAGRLR QAKLHLFRER QEVGLEKSTA
     EFDEKEHVEV TLIAGISHGF VSFVSVFPEG WKHIFRCANW IMDIFDKPPH QFEGPAIESR
     LRSGTLTHDS NSSLELASTQ LRHHRRTPTG ESVDDDAPLI MSSLRDENFK SPSKANANGT
     MKDDKQGQAR GRAMEEKSRA DKGRSKSLVS LGSEEDLLKR RMKGLTVGLM GSSHT
//