ID H6BYI3_EXODN Unreviewed; 343 AA.
AC H6BYI3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:EHY57563.1};
GN ORFNames=HMPREF1120_05593 {ECO:0000313|EMBL:EHY57563.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY57563.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY57563.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY57563.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JH226133; EHY57563.1; -; Genomic_DNA.
DR RefSeq; XP_009158024.1; XM_009159776.1.
DR AlphaFoldDB; H6BYI3; -.
DR STRING; 858893.H6BYI3; -.
DR GeneID; 20310232; -.
DR VEuPathDB; FungiDB:HMPREF1120_05593; -.
DR eggNOG; ENOG502QWBM; Eukaryota.
DR HOGENOM; CLU_031468_2_1_1; -.
DR InParanoid; H6BYI3; -.
DR OMA; RWSKLVY; -.
DR OrthoDB; 1816688at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR21708:SF30; 2-REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00740)-RELATED; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007304}.
FT DOMAIN 9..167
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 204..323
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 343 AA; 37232 MW; B4D5B3113466B4DF CRC64;
MIMSAKKNVL LVGSGGVGTM AAFSLQASGR AEVTAVLRSN YASVKLNGFN IDSVDYGNHK
GWKPAKITNT VPDVAAGGLP SFDYIVVATK NCPDIKPAVP EIIAPAVTEG HSVIVLVQNG
INIEKPLIDV FPKNIVLSGV SLIGTAEKDH GNIIHDDHDI LIVGPFKNPN IASELALAAA
MEFVDIYNTS GKVDCKLDED VGFVRWRKLV YNASFNPVAT ITRMDTSRMR IAKTPIDDLI
RPAMWEIWNT AKAAGHPLPE DHVAKTIDAD PFDVWCKPSM LQDAQKGNFI EYMNIVEEPI
KEAERLNVPT PTLKTILGFC RALQWQTREA KGMVTLPAGA PPP
//
