ID H6N875_MYCHN Unreviewed; 524 AA.
AC H6N875;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=MHC_04955 {ECO:0000313|EMBL:AEW45847.1};
OS Mycoplasma haemocanis (strain Illinois).
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=1111676 {ECO:0000313|EMBL:AEW45847.1, ECO:0000313|Proteomes:UP000009135};
RN [1] {ECO:0000313|EMBL:AEW45847.1, ECO:0000313|Proteomes:UP000009135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Illinois {ECO:0000313|EMBL:AEW45847.1,
RC ECO:0000313|Proteomes:UP000009135};
RX PubMed=22374945; DOI=10.1128/JB.06781-11;
RA do Nascimento N.C., Guimaraes A.M., Santos A.P., Sanmiguel P.J.,
RA Messick J.B.;
RT "Complete genome sequence of Mycoplasma haemocanis strain Illinois.";
RL J. Bacteriol. 194:1605-1606(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00560}.
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DR EMBL; CP003199; AEW45847.1; -; Genomic_DNA.
DR AlphaFoldDB; H6N875; -.
DR STRING; 1111676.MHC_04955; -.
DR KEGG; mhe:MHC_04955; -.
DR HOGENOM; CLU_004585_5_5_14; -.
DR Proteomes; UP000009135; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000009135}.
FT DOMAIN 1..170
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 171..437
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
SQ SEQUENCE 524 AA; 61035 MW; AFDE36CBC2357AAD CRC64;
MILKEKSIDS EGITPRTMAN IVSILKHRNP YEQPLERNEV ALHFSRKYEL SFEDLADIYN
SYAKNLREIN VLDYDDLEIL ANNLLNIEES RRYWNQYFKA ILIDEFQDTN DIQFEIIKKI
LGEHQNLFCV GDPDQSIYGF RGAKAGICRE FLDTFEDTQL VKLEENYRST KNILNVSNVL
INKNSGELSK VLFTGNEEGE KVVYREFINE WDEVNYVLDE VQYLIKREGA SLRDFAILYR
NNFLAVPFEM KIKEKKWEYS ITNSVEFYSR EEIRAVAAYL HLVFNDDATD ALYKIRALPP
KGIGEVAVRM FETFKATSNY TVLEALFHID ECPELTTRAK TAFKELGVLI EELRSKKDLG
IYDLIMFIID KSGYKKYLMD KKELGRIENI IKFAEILKSD KGADNWEVVK EIPLKTKDVV
PKTDDYILLS TVHQVKGLEF KYVFVVKMVS DVFPSYRSIT AADKSEERRL AYVAFTRAKK
RLYITKSPYS SKGTVVSNRE SEFVTDIKGL PFVDARFVTR KFFS
//
