ID H6PSW1_RICP3 Unreviewed; 350 AA.
AC H6PSW1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Multidrug resistance protein A {ECO:0000313|EMBL:AFB25958.1};
GN OrderedLocusNames=RSA_01810 {ECO:0000313|EMBL:AFB25958.1};
OS Rickettsia philipii (strain 364D).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=481009 {ECO:0000313|EMBL:AFB25958.1, ECO:0000313|Proteomes:UP000007997};
RN [1] {ECO:0000313|Proteomes:UP000007997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=364D {ECO:0000313|Proteomes:UP000007997};
RA Johnson S.L., Munk A.C., Han S., Bruce D.C., Dasch G.A.;
RT "Complete genome sequence of Rickettsia philipii strain 364D.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP003308; AFB25958.1; -; Genomic_DNA.
DR RefSeq; WP_014364514.1; NC_016930.1.
DR AlphaFoldDB; H6PSW1; -.
DR KEGG; rph:RSA_01810; -.
DR HOGENOM; CLU_018816_15_1_5; -.
DR OrthoDB; 9811754at2; -.
DR Proteomes; UP000007997; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF24; MULTIDRUG RESISTANCE EFFLUX PUMP; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..344
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 53..297
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 160..208
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 350 AA; 39116 MW; C1DF65A7F173D379 CRC64;
MPSVLQQAID KYKHHPFTKY VIIIALIIFI YLGYRIYVWA NTQSTDNAYI DADISNVSAE
VSGVLTKLFV TDNTKVNKGD LIGEIDDRDY KAKLAALEAS IEACIKNIEI IEQKISIGQS
SLEQAAEKLK LNKISFDIVA TDFMRVQELN KAKFASSKTL DDSKNAYQKA KTDYKQAQLD
LDISKQHLQL LELEKAAEQE KLKELTENKK VTLRSLQNTK LIAMVPGIFG NSSLEVGNYI
VPGRVLFSIV QDNTMYIQAN FKETQIQKFK SGMKVKIEFD ALPKKVIYGK IRNIAPATGS
KFSLIPPDHA TGNFTKSVQR VPVLIDFESP NANLVPGMSA IVSIRTDQST
//
