ID H6PT93_RICP3 Unreviewed; 341 AA.
AC H6PT93;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
DE AltName: Full=UDP-galactose 4-epimerase {ECO:0000256|ARBA:ARBA00031367};
GN OrderedLocusNames=RSA_02535 {ECO:0000313|EMBL:AFB26090.1};
OS Rickettsia philipii (strain 364D).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=481009 {ECO:0000313|EMBL:AFB26090.1, ECO:0000313|Proteomes:UP000007997};
RN [1] {ECO:0000313|Proteomes:UP000007997}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=364D {ECO:0000313|Proteomes:UP000007997};
RA Johnson S.L., Munk A.C., Han S., Bruce D.C., Dasch G.A.;
RT "Complete genome sequence of Rickettsia philipii strain 364D.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Epimerizes UDP-galactose to UDP-glucose.
CC {ECO:0000256|ARBA:ARBA00002779}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC {ECO:0000256|ARBA:ARBA00007430}.
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DR EMBL; CP003308; AFB26090.1; -; Genomic_DNA.
DR RefSeq; WP_014364602.1; NC_016930.1.
DR AlphaFoldDB; H6PT93; -.
DR KEGG; rph:RSA_02535; -.
DR HOGENOM; CLU_013560_4_1_5; -.
DR OrthoDB; 9803111at2; -.
DR Proteomes; UP000007997; Chromosome.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013692; CapD_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003869; Polysac_CapD-like.
DR PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR PANTHER; PTHR43318:SF2; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE (INVERTING); 1.
DR Pfam; PF08485; Polysacc_syn_2C; 1.
DR Pfam; PF02719; Polysacc_synt_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
FT DOMAIN 7..285
FT /note="Polysaccharide biosynthesis protein CapD-like"
FT /evidence="ECO:0000259|Pfam:PF02719"
FT DOMAIN 288..335
FT /note="UDP-glucose 4-epimerase CapD C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08485"
SQ SEQUENCE 341 AA; 38430 MW; 92E70CBD1021AC99 CRC64;
MFVDKTLMIT GGTGSFGNAV LSRFLKSGII NDIKEIRIFS RDEKKQEDMR IALNNPKLKF
YIGDVRNYKS IDEAMHGVNY LFHAAALKQV PTCEFYPMEA INTNVLGTEN VLSAAINNKV
TKVIVLSTDK AVYPINAMGL SKALMEKLAI AKARMRSPGE TVLCVTRYGN VMASRGSVIP
LFINQIKQGK ELTITEPSMT RFLMSLVDSV DLVLYAFEHG HQGDIFVQKS PASTIEVLAK
ALQDIFNSKN EICFIGTRHG EKHYESLVSS EEMAKADDLR DYYRIPMDGR DLNYAKYFVE
GEKKVALLED YTSHNTKRLN LEEVKELLLT LDYVQEELKN A
//
