ID   H6PV27_RICP3            Unreviewed;       822 AA.
AC   H6PV27;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE   AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN   OrderedLocusNames=RSA_06200 {ECO:0000313|EMBL:AFB26724.1};
OS   Rickettsia philipii (strain 364D).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=481009 {ECO:0000313|EMBL:AFB26724.1, ECO:0000313|Proteomes:UP000007997};
RN   [1] {ECO:0000313|Proteomes:UP000007997}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=364D {ECO:0000313|Proteomes:UP000007997};
RA   Johnson S.L., Munk A.C., Han S., Bruce D.C., Dasch G.A.;
RT   "Complete genome sequence of Rickettsia philipii strain 364D.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP003308; AFB26724.1; -; Genomic_DNA.
DR   RefSeq; WP_014364980.1; NC_016930.1.
DR   AlphaFoldDB; H6PV27; -.
DR   KEGG; rph:RSA_06200; -.
DR   HOGENOM; CLU_001114_0_0_5; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000007997; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          1..431
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          450..721
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   COILED          398..425
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         19..26
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   822 AA;  95297 MW;  813C3B7BE390F660 CRC64;
     MSDLQRDASD PNYSVWVSAS AGTGKTKILT DRFLRLLITG VEPSNILCLT FTNAAAIEMQ
     VRINSRLKYL SLCNAEKLEA ALFLMSGNKP SPQDTENAKT LYDKILNSNK LLNIYTIHAF
     CQKILNTFPL EAGITPEFTI LEETKLQDIF LNIRNEIYLS DEHNDLMKIL LNRFHEITLQ
     DIFTEIIEQQ IKFRKLFINK QIPKEISNKR LALGELNNIY DKVKNLFAEY DVEIAPKEIF
     FTKDGKKRKS LLSKELIRKY PKLLLELEKI TSEIYRLDEL RRIEELEYHT NLLTKLAHII
     LKKYDSYKEE NNLLDYDDLI YYTEKLLNNK TTHKWLLHKL ESEINHILVD EAQDTSLSQW
     NIITTLITEF NAVERPNNSV FIVGDDKQSI FSFQGADLRN FNLVNERLKA NLTNANKKFK
     NITLEYSYRS CTEILQFTYN VLKNIKSNYP SLFLANNPLI SSFRTHQGSV TVWPLVTSEK
     QEELFWALPE DYENSKSAAD LLIEKIVNFI KEQIESEEIL PSTANRISEK DFMILVRKRD
     EFSNNLIKEL SKAKLKVEVS DRMNLKENLT IMDLISLAKF VLLPDDDLNL AGLLKSPIIG
     ISEQQLYALL VNKSENSLWD ILSSHEEIYN KLDSLIAIYK ISIVENFFDL VVHNLNLREL
     YDDDSDDMIN ELLTLSKNYA NDIDNSLQGF VAWFENNDIY IKRDIEHSDK IRVMTVHGSK
     GLETPIVILC DSTTLPISSN KFIWDDKGEM FFSANAADTP EFLQELKEAE KLKDLQEYIR
     LLYVAMTRAK DRLIICGFSN KSTTPKNCWY EIAKQTCDQS LN
//