ID H6QCH6_PYROT Unreviewed; 735 AA.
AC H6QCH6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=alpha,alpha-trehalose-phosphate synthase (UDP-forming) {ECO:0000256|ARBA:ARBA00012538};
DE EC=2.4.1.15 {ECO:0000256|ARBA:ARBA00012538};
GN OrderedLocusNames=Pogu_1757 {ECO:0000313|EMBL:AFA39784.1};
OS Pyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7).
OC Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=698757 {ECO:0000313|EMBL:AFA39784.1, ECO:0000313|Proteomes:UP000009062};
RN [1] {ECO:0000313|EMBL:AFA39784.1, ECO:0000313|Proteomes:UP000009062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13380 / JCM 10595 / TE7
RC {ECO:0000313|Proteomes:UP000009062};
RX PubMed=23407329; DOI=10.4056/sigs.2645906;
RA Bernick D.L., Karplus K., Lui L.M., Coker J.K., Murphy J.N., Chan P.P.,
RA Cozen A.E., Lowe T.M.;
RT "Complete genome sequence of Pyrobaculum oguniense.";
RL Stand. Genomic Sci. 6:336-345(2012).
RN [2] {ECO:0000313|Proteomes:UP000009062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13380 / JCM 10595 / TE7
RC {ECO:0000313|Proteomes:UP000009062};
RA Bernick D.L., Karplus K., Lui L.M., Coker J.K.C., Murphy J.N., Cozen A.E.,
RA Chan P.P., Lowe T.M.;
RT "Complete genome sequence of Pyrobaculum oguniense.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-
CC trehalose 6-phosphate + H(+) + UDP; Xref=Rhea:RHEA:18889,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58429,
CC ChEBI:CHEBI:58885, ChEBI:CHEBI:61548; EC=2.4.1.15;
CC Evidence={ECO:0000256|ARBA:ARBA00001516};
CC -!- SIMILARITY: In the C-terminal section; belongs to the trehalose
CC phosphatase family. {ECO:0000256|ARBA:ARBA00006330}.
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DR EMBL; CP003316; AFA39784.1; -; Genomic_DNA.
DR AlphaFoldDB; H6QCH6; -.
DR STRING; 698757.Pogu_1757; -.
DR KEGG; pog:Pogu_1757; -.
DR eggNOG; arCOG02831; Archaea.
DR HOGENOM; CLU_002351_3_3_2; -.
DR Proteomes; UP000009062; Chromosome.
DR GO; GO:0003825; F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity; IEA:UniProtKB-EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0005992; P:trehalose biosynthetic process; IEA:InterPro.
DR CDD; cd03788; GT20_TPS; 1.
DR CDD; cd01627; HAD_TPP; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR001830; Glyco_trans_20.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006379; HAD-SF_hydro_IIB.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR012766; Trehalose_OtsA.
DR InterPro; IPR003337; Trehalose_PPase.
DR NCBIfam; TIGR01484; HAD-SF-IIB; 1.
DR NCBIfam; TIGR00685; T6PP; 1.
DR NCBIfam; TIGR02400; trehalose_OtsA; 1.
DR PANTHER; PTHR10788:SF106; BCDNA.GH08860; 1.
DR PANTHER; PTHR10788; TREHALOSE-6-PHOSPHATE SYNTHASE; 1.
DR Pfam; PF00982; Glyco_transf_20; 1.
DR Pfam; PF02358; Trehalose_PPase; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Hydrolase {ECO:0000313|EMBL:AFA39784.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 735 AA; 82308 MW; 577307273A099328 CRC64;
MAKLVIVSNR LPVAVSVRGG SVEIREAVGG LATAIKSFLA ATESGKTLGF DELVWVGWSG
VKAEQETEEV RAKLREMGLL TVPLTGEEFQ LFYEGFCNST LWPLFHSFTV YTVFEAKFWE
SYLQVNHKYA EAVSAVARPG DFVWVHDYHL MLVPGMLREQ APELAVGFFL HIPFPPAEVY
QLMPPPWRTA LLDGLLGADL VGFHIHEYVN NFLRSVSKFL GYRTEAGMVY AGRRKIRVGA
FPISIDFDFF HNSSEVPEVE RQIEELRQRL RGLKIVFSID RLDYTKGVIN RIHAWERFLK
ERPGWRGRAT FILVVVPSRT GVPQYEAMKR EIEREVGRIN GELGEVDWVP IVYISRYIPT
TTLLALYNIA DVALITPLKD GMNLVAKEYV ASRRDCRGVL ILSETAGAAH ELVQALVVNP
NDESGIVNAI ERALSMDPEE QCRRIKSMQE RIRQHNVVKW GVDFIHALAL AYNDNLMSAA
TPARILDGEA AEEIASAFRN SRKRLLMLDY DGTLVPHYPY AYQAVPDAEL KQMLRDLANI
PNTSVAVVSG RPRDFLEAWL GDLNIYLVAE HGAFIKEPGG GWTQLFPFDL SWKPAVRKLM
EDFTALTPGT YIEEKEVSVA WHYRNAEAEV GEAAANRLVE ALSGLLAGTP ANILRGVKVV
EVRAAGVSKG AAAKLLYEKL APDFVLIAGD DYTDEEMFKS VPAAFSVKVG RGETAAKFMA
PSYRKVRELL RRLIS
//
