ID H6R0J6_NOCCG Unreviewed; 9711 AA.
AC H6R0J6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Putative Peptidyl-dipeptidase Dcp {ECO:0000313|EMBL:CCF65465.1};
GN OrderedLocusNames=NOCYR_4710 {ECO:0000313|EMBL:CCF65465.1};
OS Nocardia cyriacigeorgica (strain GUH-2).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF65465.1, ECO:0000313|Proteomes:UP000008190};
RN [1] {ECO:0000313|EMBL:CCF65465.1, ECO:0000313|Proteomes:UP000008190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUH-2 {ECO:0000313|EMBL:CCF65465.1,
RC ECO:0000313|Proteomes:UP000008190};
RX PubMed=22461543; DOI=10.1128/JB.00161-12;
RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA Richard Y., Cournoyer B., Blaha D.;
RT "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT cyriacigeorgica GUH-2.";
RL J. Bacteriol. 194:2098-2099(2012).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
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DR EMBL; FO082843; CCF65465.1; -; Genomic_DNA.
DR RefSeq; WP_014352916.1; NC_016887.1.
DR STRING; 1127134.NOCYR_4710; -.
DR KEGG; ncy:NOCYR_4710; -.
DR eggNOG; COG0339; Bacteria.
DR eggNOG; COG0631; Bacteria.
DR eggNOG; COG2197; Bacteria.
DR eggNOG; COG3087; Bacteria.
DR HOGENOM; CLU_222679_0_0_11; -.
DR OrthoDB; 9773538at2; -.
DR Proteomes; UP000008190; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 5.
DR CDD; cd06173; MFS_MefA_like; 1.
DR Gene3D; 1.10.1370.40; -; 2.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 3.90.210.10; Heat-Labile Enterotoxin, subunit A; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 6.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR43660; DIPEPTIDYL CARBOXYPEPTIDASE; 1.
DR PANTHER; PTHR43660:SF1; DIPEPTIDYL CARBOXYPEPTIDASE; 1.
DR Pfam; PF00196; GerE; 5.
DR Pfam; PF01432; Peptidase_M3; 1.
DR Pfam; PF13672; PP2C_2; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 6.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 6.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 5.
DR PROSITE; PS51746; PPM_2; 1.
DR PROSITE; PS51996; TR_MART; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000008190};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT TRANSMEM 209..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3158..3420
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT DOMAIN 4739..4804
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
FT DOMAIN 4815..4880
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
FT DOMAIN 4892..4957
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
FT DOMAIN 4972..5037
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
FT DOMAIN 9356..9421
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
FT REGION 310..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1063..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1615..1773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1805..1828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1904..1962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2255..2342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2550..2615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2744..2765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3123..3159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3443..3477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3921..4021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4597..4636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5053..5090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5251..5302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5316..5408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5911..5995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6222..6251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6736..6758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6770..6789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6828..6895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7564..7611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7850..7871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8014..8075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8134..8162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8444..8486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9250..9282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9462..9481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..337
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..622
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1691..1712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1733..1756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1923..1937
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2262..2277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2307..2321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2593..2607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3459..3477
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3997..4021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4616..4636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5060..5080
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5267..5295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5388..5402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6773..6787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6854..6872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8024..8059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8453..8471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9250..9269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 9711 AA; 1039908 MW; C9E56ED7AB9FFFF6 CRC64;
MVDIPSLFPD WLIELVLGHL PEGNPADMRA AADLWWASSE SATALAIDFD EIGRLGSEIG
IWGDYGDDVR KWYRQCADDT RELCQDHADR AKQLEEGATQ IEFQQYVIIA IAAILLAQII
FDLTRPHPAT VLVMMQRRLA AREAMVLSLR NLVSMLRLLN ARFAVAYPRL SMITKGAAIG
ALAGGGSHAG AMGVQIAQGN RESMLWKEVG IAAAAGGAGG VVGAGLGSVI APAVSRIGAN
SASKAARVGG QVLGIVSAGA IGGLAGGAAG AWVASELSGR ELTNKDLASM MWTGMGSGIA
GSVGAAIRAA RTPPQGSSVG TAPPPDRPAP STPRFTEPPP RLRSSVTGSD GQAPRPRDLS
PAGQIRELGG DLAGRMRSED VPAGQHRDLV SEFINSQDAA PRSFREVGIG EFQQRADAYF
RQQLAEMGIG EAPGPRTGDA APGPHAAPDS PGAGGQGRSG PDSPGGQVRS PDSGGTGGQG
SGRPAPVPHG GSGPGSGPSA GVREAVPPVR TTSTVSGDAG GPNTGARNGP TAHAGGTGAE
SSQPVRGAGG AEATGRASGP ADVTAPSASR LAGDPGQVRA VPDAGAGEAG RTTADGPAAP
EPSPVPGVAA PEPSPAPSVT APETSPAPDG ATPESNPAPD VSAAHGDSGT RDAAHGTDSA
PTPPSNPGDS TFVPAHEMSA GLRNCAPEVA SYMKQATGYD GIDTLLIDNQ QAAMQGVTLE
AYAQAHNGHW RSFESPQALV DFVADNNVKV AGAVQFKDGA GAHAAAFSRN SLGRMEIHEQ
VGNIRRRTSG DLVVEWTVDA QGKQLGPDRV RIQDDAVGNW LREVGPQVEE TVGVVFEQTG
PDGTWRPALE LAPGETPQAH PSMDLLGYRS PGGADLLERG APTPDVIPEP APVNRKQFEA
AFLRDLERLG VTVEESGPST TLDADAGVGD TATPVARDAG DGPAGDVASS TREINAPLAR
DDGTKSGDDL SRPPAQAADV GTADAAPEPA APTEHAADSR NLVPDNSSGL TPESVVAAQP
SAVTGTAVTP STPPTAPTGP AAPASAVPPA AATSVAPASA SHPSSAAAAA SPLPTPASPA
PTAIPSAHLL PGSAGSPDDL PAEPDEFTPT LPSTVEFPTG TDLTTPRLPG YPLGDPPDEF
TLPPPAIYTN PAIPLPPEED TANRTPIVPR VPSSGFLDSW SNRPRFAPDD DHDEHDPTSP
LMPEAPVGPE ITPLPRSSAG QSTSLDASPA SVPLSADLGR KYPTDADESA PGAPTRPGGR
PGLNPDSLEY LDDGGVPTTQ GGLPGAALAP PPPPRIETRR PVLSTPGTRH NIRGTNPFPF
TTPWEEPWWD EVDRVEHVKD LAAAIAAHDA ELDAIADNPD EPTVDNTLDR FAESGQEYRR
LAEQQILKRP RGTRNPAAEE LDDFITGMKS RHDHEVLTNK KLFERVEKLY FQRDDLDIPS
HTKDYLQRLY QDFRHAGARL PFDQRSELAA VDAKLAVLVD EYQNNIVQAI ADAARTGLAG
LDPRQATRAT DLASELIDYI MQLPTRPSAG QQPAWSFALD DASRQLLDQV VTRLAAGGEY
SNTAIVPELL ELLKTRAALA GETHDPHHTP AYAPLTPEHR FALLTLLLLP TDHKSRQAPA
LPPGETPTES TPPSRSRPVY PATAHGLDTT RTPDSDLGAR PHTPFTKGVP VDGPMAFHTP
PGGEPGAGKD RADSSQSSDA TPVGSHGFTS ASHSPAPPDD PWAAVDVTSQ SPVAELGEPS
QQTPQDANTQ SPTDPGEAAT GLPAGTDPMP AAVDRNSADM AYLFEIWSES AETRPVRWRG
SEQPLVFRGD HRPPDVAEGQ PHPESGLLFR DGFQPNADSG GLVYASEDLE VAKGFGGGRV
YVIDAPGGYR LAGTERQEVI FPGGIRPEFI KGYYLFDPES PDEADFIENP GFGRAPGGPG
TAPSAPDAGP APAGPGSDPS GSPVALEVTV TPGDSPSTDV ARARESVRGL LADSPLADQT
PAAERMVEAL LTLAEGPAVV RASWGGQGDA QWVIVEMTDH SRSAPTRDAD GPVLELLDEQ
ARTWGMTLYR SGERTVRFTL ATPAVADGPL HDLGELVLDL AFTPEEVAPG TSKVRRSFIR
LLEDKQWPDQ EIDKVELTVS EFFGNVARYA SGGGAEVRAW LRGAGNNELT VHISDTSRRV
PDWAIPEVDE PDQVVDEPPL DQVDEAEVDR LLAGIDLDAL IARDENPYDL TTAQVAGTHG
LGGGISMQGA ISIGYELAPF GEPGKSIVLT FRMIPPDQTH TPADDRSPTT PAATQPAAPT
SPADALDIPQ RRTDSGPKHP GVMDPPSSSP GQVTAYNPHS AGSDHAHNPE PAPSEPNPDD
PAVAAMRQLL GPLATRFAFA PGARSFDFLD YGMLRAEVEA FAEQFAALRP TFDSIGGGDW
HQQVLDFLWA KADEAPITRY VNRYGASGPA DLTRLLEGIS GEVDSTGTLV LRVLSSDRTP
SGAEMFDDLW RAIGQDVRSI RAVWKNDGGQ DSNLVSFNAG IAAGLTPEDA ARTATWTGKM
ATRRGFTEVE VLSLAGPHAN HTHAVISFTQ PQTSTPGVVD PSSVPQAPSD VLDIPQRRTD
SGPKHPGVME PPSSSPDQVT AYNPHSDGSD HAHSKPVHPL VAELREVVDE QRIRDARDGI
SLEFARNAAV PNGADANHQR LIEIRGLLDE LLVHIEHPAG VDPDRFRLLT HLYHAVEARN
AASGPDRQVV DDRIAQLYEN LHPANRQPGG AAATVPAGRA LVDGGHRHFR TPVDSAEPSA
VDHAGEPPTV LSRALPHALH ATHEELLDWA GYLSSADRQQ LIGDLTSEIA AQVEAFQRGE
QPPVLPTVGT ARLLNALLWE QTHHFKATTF SGEITDYPTL FRVAQDLANR IPEAESLHAA
ANTLFNLAGA FPIGTSLAPG LFPTPFSELN FLDSIPMHLA RTVQRMVKAA HNTSRLSKSA
HPPNTAPTPA HSMSLVDALD QIHHLDRHFE MRAAGGHDWS IYLDRYLVTK SALGFDAEVG
RAIRAFGSVP VRGGDEVVSS ALPDVLTIAN YYLTRTLQHD VAFDLSQRVD EAFTAAAARA
PHSTSLNDAA QMVHMLHRSI AGRSNEAEKF TYPLAMRNFV FTHLVQNERF PELLEQIAAD
RQRTQSIGGT EPDRAPAGAG SPETPPAPAN HSEKAEGPMA AVSDIGAGPE VEGGRSTNED
AFEFRTVHLD GHEPVHLAAV ADGVGGSALG GEAALAAVRA AIASMSKASA ELTSTGEFDP
VRVVRRGMSA ARSAVADLAE TPGQANSPDS TIVLTVLQGG ELAFDWAGDT RLYWLPMDGG
TPAKLTTDDT IVPKLIADGL PEGEAIEHSF AGQTSRSLGR KLPEDATSHA TKITLHGRGY
LFLATDGAWH GAYQPVALAA ITKQAHDRSP GNHLGVATAV NEHAHTTGTT DNITDLVIWV
DAAEPTPPAD PRQVLMRTDA ATPSLGPARA VGPDEQAPGP SVPADPPAPP PPPHEQLTPY
EIADAFERKH RGTSMNLVGA LSSEQARAFA NTFHLLLTQF PIPLDVIGVS IVDGKVWSAI
AKPAVSGDEV SAGTVRFSIG SERLKELSTS DIVSHSIWIF AHALIHQGRW RAESYALDEL
RIEYVKGGGT VDDGEFAVWL REQFDEETFR DDGGFLQRLA LTRSFQKVFT KDSDATDGHR
ILYRTLVDLA TGDYQRGPSA FIRAVAAPMI RPLRNDALAA IEALHAVDRT SGLDHDDIDP
QVLQTMVRQL APYFVIFDRL HLAGLAVVPM ADESIMASVS RRGEEITLAI SERFAINAEL
HRQTNADGVA SGRFSSPGID ATAETINHEM AHVLQFFAAN VLESREILDP FANDWEAVVP
ELVKHYVGTN LPEDLGEFLT FLQRELSGYS IDEDGRPIPS EAFAEAHSSS RWGMANETER
ILATYLARRA IEANNRLRAT VAQRTEQPAP ADPNTAGHDR RTGTAPHKES PHPGVMRPPG
GFDPGMVTAF NPDSNGRDHA RQPEPRPAEP AAEPEPSTVS DTASEARPDN RSKPQAQLNE
PITSLTKLIR ADRNVAIRLG SEFLNTTGAA VAGTTLGLWL MEEAGPGVAG AVSAITGVPR
FLLSPIAGHL ADIDPKKVMW GSALAGGGTA AAATIVLASG TPYAVPILIG TTFIEVAASN
LYASSSAKVL KIMAGDAQTG LTRFYSVSGQ APAIFSRLVA PAAVATGPWL GPLFGLGTNI
VNLATMSGIP DIPSRKDEEH AGEGQGIAGQ KASFMTDLRE SMVDAFHTIY DHSLMRSINN
AHGLYWLLLG TQGLQFTSML TNSGMSPEQQ GLVGTLVPVG SVVGSFVPAR WLDKVRIKSL
IAARTTAMAG SAIAVASTSD PWIVSTAFSV GWATAGAAGL RVNTYTRQKT PDRVFGTAQA
VRTMTMSASV GLGSLAAGGA LELLGQGPAA TVIAAGTGAV ATWSILKRRF GTDKARKLLD
CMNQTVEFAH AVGLATGTEL KRGHNKPRHL ADAFGTQLVE KPLGPDPKNP LAPHLDRIAD
PTNNIDSGVL LLGYGPSKNM HALFVTHVGN GTLVIADTNI TDPEKTDPDD PDRIPRVRIR
TAGETRSDDD THQEYDLPFP DAIEELFVGE LITDDNLDLT NAHPDQPGRP APRKNAEVTG
RPEHTDGGRG RSTAGKEVVR EALPPAIRLG TTHWPSFDPI KAALTTAYTR THNVGAAHPT
AQALARMSST DFRAAYEQLD KKARGHLDEA VSNVRKKLSL TIFHEKAIDA LVDELQPQPL
DRSGTLTDLQ FTELRLAAED VPSRQIADEL GISERTVRAH LARIQYVLAA EDTASAVVAA
VRRGILSLDD LHRSPASAEQ TLTAREHDVL VAIAQGKTSA EAATALGMAE DTVNAHLERI
GEKLGSATRP GSVAVAIRTG RLAPADLAMV DSSEPTAPLT AREVDVLIWT AEGMSNKEIA
AELGLSTRSV DSYASRTNRK LNVGTRAGAV AVGLATGLIP ERLPQPLHGP ARAVERPALT
DREREVTELI AAGRSNRDIS SDLGVTPNTV KTYVAGINQK LGTHHRSGLV VAAMQAGYIP
ATLDPDPMAE TVVEGSAADR TADAAHRDVD GRRSDNRRLD DQPPPSGAPS RVEKFRAALL
STLNAASTPD PEHALAVATA DQVVAALGAL TPRERRALGI LRSGQFIPPA GRDTIRDEGI
RAADRLAGVL AERQNEPRRA AVMAASVRQL HDALARLGTQ QQQVVVGLLE RGIAPAVMAQ
RLGLSKTTIE FMVHGAVRRM AGYLAETVIA PGQPAPGQAP HEPAPSTAPP DRKRETAFQR
GQRLAREEHQ AADPQVEPDP DQLGRVLHRL NELFPAGRPA APANVGDKTS TPRDPKRARH
PWNTPNHPGV MKPPGGFDPG QVTAFNPASD GTDHAHAQPR PAAQNMPATD ARPSTNAVPT
TDAPDGQLWG GPLLDYHPPQ ADPQPGPKNS VTVRGTGHHY DLIHFRRLAE AELVRLRNKR
DLAVTLLRLD PTANDGTLLH EVSSTHPFDV TFAFRNSSAG KELVRDIERH RIAEDLVRRL
DGAATDLLHA EVFAGYYGGD TEAQAARVGD IVAKISEGTL GDFAAVLPYN GRASVARIVN
DLYRADVIPV PVADGSTAFT WLDVEKLSGG KFSEPVPVHR IEAILAQLGD DTTVIVDSDD
PWPYILQRYD GRVVRIGPDG NVERFQADDD DPPARALFLD DSGAPVSSDL LDWLNTAYDL
EHPFQLAADP GTAQAWSPLA AFRVVYSRIR SDYDQHAARI REHHPGLDER LIPGYVAIRT
YTTNHYFDEL NAALRSGDPA RAAEFHHLTG AIAAALETLP PYLGVVEREI TVSMGERMRL
LAKYRKDAIV EEPAFVSTSI TNSYYPGNVR FTIHSSTGRD ISTISESYKP GHPDLNENEV
LFAPGKHFQV LDRSWRNGKL HIELLEVAPP HELPHDRPQL TRQGSGSDLI PAGVRDSVLP
EAPPAATTTT FDRQQPWLGF HHPQDNPHKG WTAPATADSG PPLAPGEPAH PAAAENAAPE
IPAQQSVAEP PAEQRTLGKA TISVIDIGRD ADAGDAGEQA FALVEAMFRD SNLWFDDRSE
TLLLLAGELA SNIAAHPHAE GVVVATLLWT ADEVEAVRLE ARVRGAGGTQ LPLASTYADD
YGVAYEPDGY TAWVVYGNGS DRSGELIAAL SDRSDRSAPP EQPSMEPAIV PLAEAHPEIT
NTVHTAAARL SAALGTLPDG FTLSMIDSSP THLIVRAAVP GEEPASVPQD GHEWAADEAP
SQPPVTSVRL SADDPQFPTA VRETIDGAAL DWPEPIRSAL AHATTEVAAH AGSDILVRVR
AEARDSTTLR VTVAHSTRRG MPPELLQLLD RETTGWTAEV TPDARLVALH FRRIDDALVI
APRDTAAETT ITDPIQSGAM DIVLRGRPAT EARSLVRDVL TGSAGHRDVA EAMNHAEQLV
REVTNDWREG TRFTASLARS GLLTMEIVRD TPGGGTVRPR QVIFRPSDTA EPDMSIAGRE
IDESMLATVV GQAHAAMARH GWTDADQLAA VPTMLSRRLS AFADRAGGGP WRLTVTVSGQ
AGSKVLAVTA KHPREREAIP VLELFQRTAN WAPDSPAALV FYRNGWLADA HWSVGSEPMA
NASDLFDGSD MLARAEHRFA ADDDPVEVLA RPAALVDQVL DVIPSELIRA DARMAATSLA
LGLTERLVAD PGGEALLTGL VTMGLHGLEF RVAVADRRPD GSGDQVYDRL AARSGSESWG
GGTITWASLD LRPEVAGDVL PNADPGTDPA STPPGTGTAD VVDAIARVLG EDSPNRQTDT
QTPTSAARPV ADVLADIDEI APDPGDHSPA TPSPSRSVAD VLAGIDEVAP APEPGTPPAA
GAGNPPQARQ AAASPDHRRT TGSPTPWSRS TEAMPSPGEP DQPASTSRAD AKPAWGKTIA
SAAEFDRARA ELAGLLQIDT ALLPDHRAVL RALKPIRNAL SGLDEQGWHV VGHAHQPDQI
ATWIGQKITA EAATRAATGP RERGRWMEAL DTLENSLPEL LGLPDGGAWN GSILGGSPLT
ELRRLHDHAP GESGLGPLIS ALARFLEIDS RAALHAELYP TATDVIDAFE TRHPYTDIHG
VNRLRDSTAH VLVQTLHQVL VQYPIRLPVV RVNVEPHQTD LFAYVVPEVD DDNEVSARSL
VLEIGRDDVD TVSDEDLRGT VLRAFAGAMI YAGRWRAEAY AISRLRWHKE EELGISEADL
TFLEWSFSQF DGAHFLDDGS LDMRTALRES FEKVESNAPG VTSGERVLHR LLVDFAREWD
GRNESALRRP LTAFEERLRE VKAPLIRELE AEFGLELVGF DTSDVRPQTV RDFADEYRRH
YDEFGGTDVT KIVIAPFAND ETFAMIDFTD DGMVLLWNER YAINRALFRY VTEENVDSGY
HAGPRDEPIG NTISHELGHA IANYPHRDDA GAGYTNLLER YSLLAENDLA WVFVEFAEHY
LRENAPQELA DFQDQIAMLA ARETEALQNH PGSHPNWHEF LPEFVEGFFE RQLPGHLDGF
VAYLTTTMAG FTGYSYVENA PERSIDYINP SEAFAEALTA HRWHTATEGQ RIVADFLARR
AKAERARRQD AEDVGVPPRA KPPAMPGEPR TSPPFARTGG QGRPDPQPRS LWLFSGDDVF
ATIRSALDTA APCWTEDRRD AVAATMAVVA ADALMVSTEA GIRAFAQPLP DEGLHMVVEH
TGDNKLAPEV ARALDERAGV WRAEMPRGRR RIVAEFQRTD EVYPRTRERA AWEARFAPYF
YTPDEDIHYR QFDIDQSADP VSAAGRLVRD FMQEHAQGTE REIRDLAALA ESIVRMTVDA
WHSDRTFSVQ ISRSGVLSLT VMYDQGVGYV PGTEYEIVFR PATRPSTEVS VVSPASVEPA
GAHRQTDDSA PVKSGLYDGP DAHVRAVHRF PAGTDADQAY GRVLELIDRA FTGISPEAMR
ADARPAAALL AAELVHNLVV TTGGETLLTG QVALGKHGLE FHVTVADRRP VDAVTDDGWR
VADLVAADRA IRAGVEPRDS GKITWAVMDL RPGTGGHDFP AGHDSSANPS TGHRVTTDPA
PTTAPRRASS TAENLSSPPT PWSPQQPAAV PSPWQRTANE MRNDAAAAPA FGAKGAMPPD
EADIGAALGI DDRRARAYTD PTVHGYRRNP WVLNRFGPGD TGPDESRAPA PEPGHQARTP
VAEEQGIRLG KIEVHPRAAE FDVIPVDPMM YIPGIAEVLD VETVYFDWKG RVRDRDSGPY
TTGPAGDNFF VTPEEIRTSP VPSTHAMIYS SYRKPGHFPI VLGHWSMSGG REVSVTFGSS
LLHTESALVK NSAYGRYLMA QHGDSSIIRI SDESEGALWR KHKPAGLPTV IELIEAAGSS
SGAGGFSAEE MFLGGVEDFW VDIVDIVAAP NRLSITFSVN MVLGESENVT LVLTHGDDAD
TAAYTRDIRP GDKPRPVDLA VEKFHVIAVA PWLASSQAHY SDGADDRLAT TDALPPASTQ
SPQTAAESID DASANEATPA PQPLTAESNP VFASVVDPHA DPAFDSMKAE HFPPVFEYAI
QEQWNALETI IANHELWTAG NTLHSFAESG RALGAVKQLF SEKAAVDRDA ATAQVEPIIA
EMQQAHQNRV LTDPALAAIF KHLYEHRGEL GLTERERGYV EWKYQDFVRA GAYLASEQGR
RELAEINAAL PELRTEYKAN QQKAIDAFQF RVDTVELLDG LNDDQIAAAR ERAGESPGYV
LPKPSAPSGF WYPYLSHLKD PELSRRLYDS VANLAVGGAF DNSANVLAQA EKAARRAQLT
GYANHADYVT AGGIFDSVEE IEAILGQIAS AAADAARIEL PRLAQAIGAD EIHPWTRFRA
IEAALGTMVG IDEQRMREFF VLDRVLSDGV FHLANLLFGL TFTELSGDSK PSVWDDDVRV
FAVTDADGRR VSTVYFDPYA RDGKNSGEWS DPIRLNFTGQ NPVIGVHLNI TKPPPGTPTL
LTPHEVSALF HEFGHELHFS LGEGTFEAAN RHLVFGWLEF VAKMFQRFWQ HPDVLSRFAV
HHETGRPMPA EELARFEEWR TAYRGTATIF RLSGAYIDLA WSSLTPDQIP QGSDVVALVK
EFDIAALIRA GIYFPEIGNL YPSQWFRHLY GEMGGFGVYL GQYSSYLLSD VFAPIAFYLH
IAPVLAEHGL GPEVGNVFRK LVFGPEENNL AQAKRSLVGT NSAVDMFLAD QRLLWTRALA
KLGQGATPEW LTTPTARPPD TDLASWWNTR LSADEQAAMI QSFPDDVLAM DIDHSRATVE
AATARQQTLR EYAHQAQRTS STSGSRAGDH PPSSRADSTE LAHTERDLDA EDIDILALLA
DGYSLAEISA QHYLSRSTLR NRLDAIAAKL GTDSTIGSAV RAWQRGLLRL GERDLMPASA
GSFTRDEVET LALLARGLSN AQVAEHQHVS RSTVQDRLAR VFDKLGVHGR IPAVLAALDR
GVIGSELVDA QPVTVTRPPS FAPADTRSTS DAVPRVVTTA RPEVPVEPTE PPPRRGSLVP
ILGTDLSTGR DIEIDPNDVR TLTLGNEHGH DDVVFLPSSY DRDDAFAHWA GRRYRDLDHI
YTAYQRPGGP PVRYTIASPE PAVWQREVRA TGKAPFIVIT HANGNHYSLQ VRVGDGWQDV
FVGGVEYARL LTNNAQFMNL LAQDEYRPLI IGSCSPAQNG SSTAQFTAEY LINEAEMDRN
IHLAKSVLAF HSKGDTAILA VEAMITRNGA HLPLFDSWWG SPWAYEYRPD R
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