ID H6RDK1_NOCCG Unreviewed; 532 AA.
AC H6RDK1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=L-glutamate gamma-semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00012884};
DE EC=1.2.1.88 {ECO:0000256|ARBA:ARBA00012884};
DE AltName: Full=L-glutamate gamma-semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00032259};
GN Name=pruA {ECO:0000313|EMBL:CCF65252.1};
GN OrderedLocusNames=NOCYR_4496 {ECO:0000313|EMBL:CCF65252.1};
OS Nocardia cyriacigeorgica (strain GUH-2).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF65252.1, ECO:0000313|Proteomes:UP000008190};
RN [1] {ECO:0000313|EMBL:CCF65252.1, ECO:0000313|Proteomes:UP000008190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUH-2 {ECO:0000313|EMBL:CCF65252.1,
RC ECO:0000313|Proteomes:UP000008190};
RX PubMed=22461543; DOI=10.1128/JB.00161-12;
RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA Richard Y., Cournoyer B., Blaha D.;
RT "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT cyriacigeorgica GUH-2.";
RL J. Bacteriol. 194:2098-2099(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-
CC glutamate + NADH; Xref=Rhea:RHEA:30235, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58066; EC=1.2.1.88;
CC Evidence={ECO:0000256|ARBA:ARBA00001468};
CC -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC glutamate; L-glutamate from L-proline: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004786}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO082843; CCF65252.1; -; Genomic_DNA.
DR AlphaFoldDB; H6RDK1; -.
DR STRING; 1127134.NOCYR_4496; -.
DR KEGG; ncy:NOCYR_4496; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_4_1_11; -.
DR UniPathway; UPA00261; UER00374.
DR Proteomes; UP000008190; Chromosome.
DR GO; GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0010133; P:proline catabolic process to glutamate; IEA:UniProtKB-UniPathway.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR005931; P5CDH/ALDH4A1.
DR NCBIfam; TIGR01236; D1pyr5carbox1; 1.
DR PANTHER; PTHR42862; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR42862:SF1; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Proline metabolism {ECO:0000256|ARBA:ARBA00023062};
KW Reference proteome {ECO:0000313|Proteomes:UP000008190}.
FT DOMAIN 44..499
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 532 AA; 57366 MW; 0E1C2D90449D11DE CRC64;
MHSYAPGSPE RERLASKLAA ISAETVEIPL VVGGKHRPGI GARHEIVAPH RHRQVLGTYT
DITHAEASDA IDAAIAAAPG WRALPFDERA AVLLRAADLL SGPWRETVAA ATMLGQSKSV
QQAEIDAPCE LIDFWRFNVA FAREILEQQP RSSAGVWNRM DYRPLEGFVY AITPFNFTAI
AGNLPTAPAL MGNTVVWKPS PTQTLAAYYT MRLLEAAGLP PGVINMVTGD GVELSEVALA
DPRLAGIHFT GSTKTFQYLW RQVGANVGSY HGYPRLVGET GGKDFIVAHT SADPAALTTA
LVRGAYEYQG QKCSAASRAY LPRSLWRQMG DDFLELTGNL AYGDVADLTN FGGAVIDRRA
YDKSVTAIER ARSAGLSIPV GGTYDDEEGF FVRPTVLLAD DPRDEAFTTE YFGPILSVYV
YDDGEPGAYA SVLSEVESTA PYALTGAVFA QDRHAIEQAS QALRFAAGNF YVNDKPTGAV
VGQQPFGGAR SSGTDDKAGS PLNLLRWVAP RVIKETFVPP DDHRYPHMGS QA
//