ID H6RMW8_BLASD Unreviewed; 848 AA.
AC H6RMW8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Diguanylate cyclase (GGDEF) domain-containing protein {ECO:0000313|EMBL:CCG05156.1};
DE EC=2.7.7.65 {ECO:0000313|EMBL:CCG05156.1};
GN OrderedLocusNames=BLASA_4334 {ECO:0000313|EMBL:CCG05156.1};
OS Blastococcus saxobsidens (strain DD2).
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Blastococcus.
OX NCBI_TaxID=1146883 {ECO:0000313|EMBL:CCG05156.1, ECO:0000313|Proteomes:UP000007517};
RN [1] {ECO:0000313|EMBL:CCG05156.1, ECO:0000313|Proteomes:UP000007517}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DD2 {ECO:0000313|EMBL:CCG05156.1,
RC ECO:0000313|Proteomes:UP000007517};
RX PubMed=22535935; DOI=10.1128/JB.00320-12;
RA Chouaia B., Crotti E., Brusetti L., Daffonchio D., Essoussi I., Nouioui I.,
RA Sbissi I., Ghodhbane-Gtari F., Gtari M., Vacherie B., Barbe V., Medigue C.,
RA Gury J., Pujic P., Normand P.;
RT "Genome Sequence of Blastococcus saxobsidens DD2, a Stone-Inhabiting
RT Bacterium.";
RL J. Bacteriol. 194:2752-2753(2012).
RN [2] {ECO:0000313|Proteomes:UP000007517}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DD2 {ECO:0000313|Proteomes:UP000007517};
RA Genoscope.;
RT "Complete genome sequence of Blastococcus saxobsidens strain DD2.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FO117623; CCG05156.1; -; Genomic_DNA.
DR AlphaFoldDB; H6RMW8; -.
DR STRING; 1146883.BLASA_4334; -.
DR KEGG; bsd:BLASA_4334; -.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_70_49_11; -.
DR OrthoDB; 23692at2; -.
DR Proteomes; UP000007517; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0052621; F:diguanylate cyclase activity; IEA:UniProtKB-EC.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotidyltransferase {ECO:0000313|EMBL:CCG05156.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007517};
KW Transferase {ECO:0000313|EMBL:CCG05156.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 438..571
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 577..830
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 848 AA; 91319 MW; E7A53FED78A6F816 CRC64;
MQVPEQDVRE PARPPVTTRS PWGVAVLALA LAVPLGVAVV ERGPLSVDVP VLLAVFLTAV
VAEWVNVHIE FRHQSFVNSA SELVFVIALL EIGGVWTAVT RAAAVGVVLG IQRFSRAKLV
FNVAVAIIDT AVAVFVLGLL PVGDVTDPWT WVSCLVAVFA ANAVAAVMVA GAIVMTQGYS
GRALWTSLLV PVVVVSPVAV LIGLAILLLL HAAPWSWVII APLAVALVLL YRRFAAVTRE
GNSLQQVYEF ARRVEEVRPD EAGTRQIVQA VRELLNAERV ALWLPPYLDE GPRLVVATES
GAHWYDGPGD PDDPLRRRAV LSTDGVIQVC AARADESEVA ALARRGVSDV LGAPVTTAAG
EPGYLEVCDR RSDLVTFGTS ERGALDSMLT HVNAAIRQQQ LLTRIRFDAD HDRLTGLPNR
QRLAAEIDQL LSADPADARA GLILASLGTY ADVTDTLGHA ASDELLLVTA GLLREHAPPR
ALLARMEREQ FAVLLPGLSL DETERAARRL REAAATRVRV AGLDLEVSLT IGVVAAPVHG
THAGALMQRA DVALLAAGDS GGVASYHPVM DQQSLRRLQL GTELEQAMAD GQIGVVFQPV
IDAQSSDIVS VETLVRWTHP RYGAVPPEDV IGLAEQIGRI GALTDHVLDL ALARCRRWLD
QGIALSVAVN VSARSLADPD LVDRVRSALE RHRVPGELLV LELTESSVVD DQVRESSVLE
HLHDLGLRLS MDDFGTGYSS LSQLRQLPID EVKIDKSFVL TMATSQGESF IARSIIELAH
NLGLCVVAEG VEDEMTRNQL TAMGCDKLQG FLISRPLPED RLDKWLLART GVRSAAPGAI
HRRLFVRT
//
