ID H6RV46_BLASD Unreviewed; 311 AA.
AC H6RV46;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Hydroxymethylglutaryl-CoA lyase {ECO:0000313|EMBL:CCG05765.1};
DE EC=4.1.3.4 {ECO:0000313|EMBL:CCG05765.1};
GN OrderedLocusNames=BLASA_4991 {ECO:0000313|EMBL:CCG05765.1};
OS Blastococcus saxobsidens (strain DD2).
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Blastococcus.
OX NCBI_TaxID=1146883 {ECO:0000313|EMBL:CCG05765.1, ECO:0000313|Proteomes:UP000007517};
RN [1] {ECO:0000313|EMBL:CCG05765.1, ECO:0000313|Proteomes:UP000007517}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DD2 {ECO:0000313|EMBL:CCG05765.1,
RC ECO:0000313|Proteomes:UP000007517};
RX PubMed=22535935; DOI=10.1128/JB.00320-12;
RA Chouaia B., Crotti E., Brusetti L., Daffonchio D., Essoussi I., Nouioui I.,
RA Sbissi I., Ghodhbane-Gtari F., Gtari M., Vacherie B., Barbe V., Medigue C.,
RA Gury J., Pujic P., Normand P.;
RT "Genome Sequence of Blastococcus saxobsidens DD2, a Stone-Inhabiting
RT Bacterium.";
RL J. Bacteriol. 194:2752-2753(2012).
RN [2] {ECO:0000313|Proteomes:UP000007517}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DD2 {ECO:0000313|Proteomes:UP000007517};
RA Genoscope.;
RT "Complete genome sequence of Blastococcus saxobsidens strain DD2.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA lyase family.
CC {ECO:0000256|ARBA:ARBA00009405}.
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DR EMBL; FO117623; CCG05765.1; -; Genomic_DNA.
DR RefSeq; WP_014378626.1; NC_016943.1.
DR AlphaFoldDB; H6RV46; -.
DR STRING; 1146883.BLASA_4991; -.
DR KEGG; bsd:BLASA_4991; -.
DR eggNOG; COG0119; Bacteria.
DR HOGENOM; CLU_022138_3_2_11; -.
DR OrthoDB; 9784013at2; -.
DR Proteomes; UP000007517; Chromosome.
DR GO; GO:0004419; F:hydroxymethylglutaryl-CoA lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07938; DRE_TIM_HMGL; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR043594; HMGL.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42738; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR PANTHER; PTHR42738:SF7; HYDROXYMETHYLGLUTARYL-COA LYASE; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:CCG05765.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007517}.
FT DOMAIN 12..278
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 311 AA; 31649 MW; 46ED71B7A1C648F9 CRC64;
MFEFDLVLPT SVDVREVGMR DGLQLEAPVP LEAKLAMLEA LVATGVRRIE ATSFVSPKAV
PALADADQVA AELTRWPEVH WSALVANPRG AVRAVDAGVA HLEYVVSASD GHSRANAGRS
TAEAVAAVSE IAGLAHGAGG SLEVIIATAW DCPFDGRTPV ARTVDVARAA VTAGADQLCL
GDTIGTTTPL RVVTLVGAVR RACPGIAVGV HFHDTRGTGQ ANALAAVQAG VTQLDASVGG
LGGCPFAPGA SGNIATEELV YMLEESGVRT GLDLDALLAA ARVTEDAVGH ELPSSLYRAG
GRSVPRPAGA S
//
