ID H6U655_CHICK Unreviewed; 327 AA.
AC H6U655;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=POU domain protein {ECO:0000256|RuleBase:RU361194};
GN Name=Pit-1 {ECO:0000313|EMBL:AEY82658.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AEY82658.1};
RN [1] {ECO:0000313|EMBL:AEY82658.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:AEY82658.1};
RA Bhattacharya T.K., Priyanka M., Chatterjee R.N.;
RT "Polymorphism of Pit-1 gene in chicken.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEY82656.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:AEY82656.1};
RX PubMed=22499861;
RA Bhattacharya T.K., Chatterjee R.N., Priyanka M.;
RT "Polymorphisms of Pit-1 gene and its association with growth traits in
RT chicken.";
RL Poult. Sci. 91:1057-1064(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-1
CC subfamily. {ECO:0000256|ARBA:ARBA00008811}.
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DR EMBL; JN613444; AEY82656.1; -; Genomic_DNA.
DR EMBL; JN613446; AEY82658.1; -; Genomic_DNA.
DR AlphaFoldDB; H6U655; -.
DR VEuPathDB; HostDB:geneid_374215; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR PANTHER; PTHR11636:SF84; PITUITARY-SPECIFIC POSITIVE TRANSCRIPTION FACTOR 1; 1.
DR PANTHER; PTHR11636; POU DOMAIN; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transcription {ECO:0000256|RuleBase:RU361194}.
FT DOMAIN 159..233
FT /note="POU-specific"
FT /evidence="ECO:0000259|PROSITE:PS51179"
FT DOMAIN 247..307
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 249..308
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 327 AA; 36827 MW; 3FF907F369869D97 CRC64;
MYLESSCIFL PVPSVLSLKQ TPNCPHLHFA MMTSGKVSAG LHYSVPSCHY GNQASTYGVM
AGIKPATPEM LSASLSQSRI LQTCSMPHPN VVNGVSTLQS SLTPCLYKFP EHALSASSCA
LGHSFTPMHQ TLLSDDPTAS DFKQEFRRKS KSVEEPVDMD SPEIRELEKF ANEFKLRRIK
LGYTQTNVGE ALAAVHGSEF SQTTICRFEN LQLSFKNACK LKSILSKWLE EAEQVGALYN
EKVGVNERKR KRRTTISISA KEALERHFGE QSKPSSQEIM RMAEGLNLEK EVVRVWFCNR
RQREKRVKTS LHQNAFSSII KEHHECR
//
