ID H6UEN2_9PELO Unreviewed; 598 AA.
AC H6UEN2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012418};
DE EC=2.7.7.6 {ECO:0000256|ARBA:ARBA00012418};
DE Flags: Fragment;
OS Caenorhabditis macrosperma.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1094328 {ECO:0000313|EMBL:AET24996.1};
RN [1] {ECO:0000313|EMBL:AET24996.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JU1857 {ECO:0000313|EMBL:AET24996.1};
RX PubMed=22103856; DOI=10.1186/1471-2148-11-339;
RA Kiontke K.C., Felix M.A., Ailion M., Rockman M.V., Braendle C.,
RA Penigault J.B., Fitch D.H.;
RT "A phylogeny and molecular barcodes for Caenorhabditis, with numerous new
RT species from rotting fruits.";
RL BMC Evol. Biol. 11:339-339(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550};
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DR EMBL; JN636053; AET24996.1; -; mRNA.
DR AlphaFoldDB; H6UEN2; -.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02584; RNAP_II_Rpb1_C; 1.
DR Gene3D; 3.30.1360.140; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR007075; RNA_pol_Rpb1_6.
DR InterPro; IPR007073; RNA_pol_Rpb1_7.
DR InterPro; IPR038593; RNA_pol_Rpb1_7_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR Pfam; PF04992; RNA_pol_Rpb1_6; 1.
DR Pfam; PF04990; RNA_pol_Rpb1_7; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 2: Evidence at transcript level;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 17..598
FT /note="RNA polymerase Rpb1"
FT /evidence="ECO:0000259|Pfam:PF04998"
FT DOMAIN 83..266
FT /note="RNA polymerase Rpb1"
FT /evidence="ECO:0000259|Pfam:PF04992"
FT DOMAIN 351..485
FT /note="RNA polymerase Rpb1"
FT /evidence="ECO:0000259|Pfam:PF04990"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AET24996.1"
FT NON_TER 598
FT /evidence="ECO:0000313|EMBL:AET24996.1"
SQ SEQUENCE 598 AA; 67777 MW; 18BAF8BEE5D84038 CRC64;
DYGPESKGFV ENSYLAGLTP SEFFFHAMGG REGLIDTAVK TAETGYIQRR LIKAMESVMV
NYDGTVRNSL AQMVQLRYGE DGLDGMWVEN QNMPTMKPNN AVFERDFRMD LTDNKFLRKN
YSEDVVREIQ ESQDGISLVE SEWSQLEEDR RLLRKIFPRG DAKIVLPCNL QRLIWNAQKI
FKVDLRKPVN LSPLHVINGV RELSKKLIIV SGNDEISKQA QYNATLLMNI LLRSTLCTKK
LCTTAKLNTE AFDWLLGEIE TRFQQAIAQP GEMVGALAAQ SLGEPATQMT LNTFHYAGVS
AKNVTLGVPR LKEIINVSKQ LKTPSLTVFL TGAAAKDPEK AKDVLCKLEH TTLKKVTCNT
AIYYDPDPKN TVITEDEEWV SIFYEMPDHD LSRTSPWLLR IELDRKRMVD KKLTMEMIAD
RIHGGFGNDV HTIYTDDNAE KLVFRLRITG DEKGADTQEE QVDKMEDDVF LRCIEANMLS
DLTLQGIPAI SKVYMNQPNT DDKKRIIITP EGGFKSVADW ILETDGTALL RVLSERQIDP
VRTTSNDICE IFEVLGIEAV RKAIEREMHN VISFDGSYVN YRHLALLCDV MTAKGHLM
//
