ID   H6WUT9_9ALPH            Unreviewed;       841 AA.
AC   H6WUT9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=Replication origin-binding protein {ECO:0000256|ARBA:ARBA00014069};
DE   AltName: Full=OriBP {ECO:0000256|ARBA:ARBA00031715};
GN   ORFNames=MDV021 {ECO:0000313|EMBL:AEZ51662.1,
GN   ECO:0000313|EMBL:AUB51177.1};
OS   Gallid alphaherpesvirus 2.
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Mardivirus;
OC   Mardivirus gallidalpha2.
OX   NCBI_TaxID=10390 {ECO:0000313|EMBL:AEZ51662.1, ECO:0000313|Proteomes:UP000133397};
RN   [1] {ECO:0000313|EMBL:AEZ51662.1, ECO:0000313|Proteomes:UP000133397}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMS {ECO:0000313|EMBL:AEZ51662.1};
RX   PubMed=22476905; DOI=10.1007/s11262-012-0739-4;
RA   Cheng Y., Cong F., Zhang Y.P., Li Z.J., Xu N.N., Hou G.Y., Liu C.J.;
RT   "Genome sequence determination and analysis of a Chinese virulent strain,
RT   LMS, of Gallid herpesvirus type 2.";
RL   Virus Genes 45:56-62(2012).
RN   [2] {ECO:0000313|EMBL:AUB51177.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Polen5 {ECO:0000313|EMBL:AUB51177.1};
RX   PubMed=29151863; DOI=10.1111/eva.12515;
RA   Trimpert J., Groenke N., Jenckel M., He S., Kunec D., Szpara M.L.,
RA   Spatz S.J., Osterrieder N., McMahon D.P.;
RT   "A phylogenomic analysis of Marek's disease virus reveals independent paths
RT   to virulence in Eurasia and North America.";
RL   Evol. Appl. 10:1091-1101(2017).
CC   -!- FUNCTION: Functions as a docking protein to recruit essential
CC       components of the viral replication machinery to viral DNA origins. In
CC       the presence of the major DNA-binding protein, opens dsDNA leading to a
CC       conformational change in the origin that facilitates DNA unwinding and
CC       subsequent replication. {ECO:0000256|ARBA:ARBA00025279}.
CC   -!- SIMILARITY: Belongs to the herpesviridae OriBP family.
CC       {ECO:0000256|ARBA:ARBA00007195}.
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DR   EMBL; JQ314003; AEZ51662.1; -; Genomic_DNA.
DR   EMBL; MF431496; AUB51177.1; -; Genomic_DNA.
DR   Proteomes; UP000133397; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003450; Replication_origin-bd.
DR   Pfam; PF02399; Herpes_ori_bp; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Helicase {ECO:0000313|EMBL:AUB51177.1};
KW   Hydrolase {ECO:0000313|EMBL:AUB51177.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          45..210
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
SQ   SEQUENCE   841 AA;  95102 MW;  2E7AE8B2BCE4FDCD CRC64;
     MIDYASSASL SRMLYGEDLI DWIIKNRPGI TTERQSDGPV TFPSPLYPRT RNVLIVRAPM
     GSGKTTALMN WLQCILCNSN MSVLIVSCRR SFTNTLSEKI NRAGMSGFCT YLSSSDYIMR
     GREFSRLLVQ IESLHRVDSK LLDNYDIVIL DEIMSTIGQL FSPTMKHLCQ VDNILTSLLR
     YRPKIVAMDA TINTQLIDML AIMRGEENIH VIVGEYAASG FSRRSCTILR SLGTNILLSV
     MNEFKQLPSH TQPIFKQSTG VNGSLDISLH DRTFFSELTR RLEGGLNICL FSSTISFSEI
     VARFCLAYTD SVLVLNSTRN TPIDINSWSN YRVVIYTTVV TVGLSFNDSH FHSMFAYIKP
     TINGPEMVSV YQSLGRIRSL RLNEVLIYID ASGARSEPVF TPMLLNHVIA NGGGWPTRFS
     QVTNMLCHNF RRDCIPTFRA ADALYIFPRF KYKHLFERCT LNNVSDSINI LHALLESNLI
     HVRFDGCDLQ LNAEAFCDFL VILRADSITA QRDMKTLRKN ATCPLPVEVD VIDSDAVACF
     VQKYLRPTVL ANDLTELLTK LAEPITREQF INITMLEACR ATPAALYSEA VFCRIYDYYA
     SGNIPIIGPS GTLDTTILTC DFNTSGRWDL YRVCCKWAEL LGINPLEGPN ADIDPTKLLH
     VMKDDYDIYA RSVLEIARCY LIDAQTALKR PVRATKCALS GIQNSHHSQP STQSHAVSLF
     KVTWEILFGL RLTKSTTTFP GRTKVKNLRK AEIEALLDGA GIDRTSCKTH KDLYTLLMKS
     KSLFRNMRYD IRRPKWYDLL RSRLDKELGI YHDLVDLESV LAEIPSALWP RVEGAVDFHR
     L
//