ID H6WX90_9VIRU Unreviewed; 522 AA.
AC H6WX90;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 03-MAY-2023, entry version 44.
DE RecName: Full=Non-structural polyprotein 1AB {ECO:0000256|ARBA:ARBA00019743};
DE Flags: Fragment;
OS Astrovirus wild boar/WBAstV-1/2011/HUN.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Stellavirales; Astroviridae; Mamastrovirus.
OX NCBI_TaxID=1137931 {ECO:0000313|EMBL:AEZ67025.1, ECO:0000313|Proteomes:UP000168579};
RN [1] {ECO:0000313|EMBL:AEZ67025.1, ECO:0000313|Proteomes:UP000168579}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild boar/WBAstV-1/2011/HUN {ECO:0000313|EMBL:AEZ67025.1};
RX PubMed=22398915; DOI=10.1007/s00705-012-1272-4;
RA Reuter G., Nemes C., Boros A., Kapusinszky B., Delwart E., Pankovics P.;
RT "Astrovirus in wild boars (Sus scrofa) in Hungary.";
RL Arch. Virol. 157:1143-1147(2012).
CC -!- FUNCTION: Contains the viral protease participating in the cleavage of
CC the polyprotein into functional products. It contains also the
CC activities necessary for replication of genomic RNA, as well as
CC transcription of subgenomic mRNA. {ECO:0000256|ARBA:ARBA00029407}.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|ARBA:ARBA00004301};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004301}.
CC -!- SIMILARITY: Belongs to the astroviridae polyprotein 1AB family.
CC {ECO:0000256|ARBA:ARBA00005873}.
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DR EMBL; JQ340310; AEZ67025.1; -; Genomic_RNA.
DR RefSeq; YP_005271208.1; NC_016896.1.
DR GeneID; 11763562; -.
DR KEGG; vg:11763562; -.
DR OrthoDB; 2087at10239; -.
DR Proteomes; UP000168579; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23172; ps-ssRNAv_Astroviridae_RdRp; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 268..394
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEZ67025.1"
SQ SEQUENCE 522 AA; 60717 MW; 267BC1358A944EA9 CRC64;
WSFTSVRWPR IPTEDEAKKR QAGAPRSPEA DLGAWKKSAV KPRRHLVPDG YPVYCNLPVN
RPICDYNIPD EPLLGILPPA QSEFEYAPTV WGPEAFAKSF EKFDYAPYCD FERDYPECTQ
FADWAWRVHH SYLEDTKVIH ISATEKNLDS TPAYPKMLDY ETEEDFLDEH GWDPYVSAFS
AIDRGYQPDV LWYCFLKKEI LKKKKIEDSD IRQIVCADPI YARIGACFEQ HQNHLTKLHT
ETKSGQCGWS PFNGGFTRLC ERLESKPGVF VELDWTRFDG TIPAPLLKRI KKLRFSMLCE
EHQKRYQHIY AWYVKQLLNR FVMMPSGEVT KQTRGNPSGQ ISTTIDNNMV NIWLQAFEFC
WFFGPDKELW RDYDTIVYGD DRLTRYPILP ENYKEKGTIH LYKSVFGMWN KTRKVKTSET
LEGLTFCGFT VGPDRLPYPT DEEKLYAGLV TPARKLPDVT ALHGKLLSLQ LLMHNHPDSA
FKDYINKCLA ETARHAEDLP ARLTERQMDR LWRGGPKHKP NG
//
