ID H7C4A3_HUMAN Unreviewed; 107 AA.
AC H7C4A3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Tissue factor pathway inhibitor 2 {ECO:0000313|Ensembl:ENSP00000416370.1};
DE Flags: Fragment;
GN Name=TFPI2 {ECO:0000313|Ensembl:ENSP00000416370.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000416370.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000416370.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000416370.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC002076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H7C4A3; -.
DR SMR; H7C4A3; -.
DR MassIVE; H7C4A3; -.
DR MaxQB; H7C4A3; -.
DR PeptideAtlas; H7C4A3; -.
DR ProteomicsDB; 45605; -.
DR Antibodypedia; 4115; 598 antibodies from 34 providers.
DR Ensembl; ENST00000451238.1; ENSP00000416370.1; ENSG00000105825.14.
DR UCSC; uc064fkf.1; human.
DR HGNC; HGNC:11761; TFPI2.
DR VEuPathDB; HostDB:ENSG00000105825; -.
DR GeneTree; ENSGT00940000159917; -.
DR HOGENOM; CLU_2215853_0_0_1; -.
DR ChiTaRS; TFPI2; human.
DR Proteomes; UP000005640; Chromosome 7.
DR Bgee; ENSG00000105825; Expressed in stromal cell of endometrium and 128 other cell types or tissues.
DR ExpressionAtlas; H7C4A3; baseline and differential.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR SMART; SM00131; KU; 1.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Proteomics identification {ECO:0007829|EPD:H7C4A3,
KW ECO:0007829|MaxQB:H7C4A3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 17..70
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000416370.1"
SQ SEQUENCE 107 AA; 12007 MW; 1EE2C1DE8A3A3905 CRC64;
EACDDACWRI EKVPKVCRLQ VSVDDQCEGS TEKYFFNLSS MTCEKFFSGG CHRNRIENRF
PDEATCMGFC APKKNTEPVM LSPILAVEGM TITLLAGRIA NVHVQKL
//
