ID H8I4Z4_METCZ Unreviewed; 446 AA.
AC H8I4Z4;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=rad25 {ECO:0000313|EMBL:AFD01088.1};
GN OrderedLocusNames=Mtc_2355 {ECO:0000313|EMBL:AFD01088.1};
OS Methanocella conradii (strain DSM 24694 / JCM 17849 / CGMCC 1.5162 /
OS HZ254).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanocellales; Methanocellaceae; Methanocella.
OX NCBI_TaxID=1041930 {ECO:0000313|EMBL:AFD01088.1, ECO:0000313|Proteomes:UP000005233};
RN [1] {ECO:0000313|EMBL:AFD01088.1, ECO:0000313|Proteomes:UP000005233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24694 / JCM 17849 / CGMCC 1.5162 / HZ254
RC {ECO:0000313|Proteomes:UP000005233};
RX PubMed=22493204; DOI=10.1128/JB.00207-12;
RA Lu Z., Lu Y.;
RT "Complete genome sequence of a thermophilic methanogen, Methanocella
RT conradii HZ254, isolated from Chinese rice field soil.";
RL J. Bacteriol. 194:2398-2399(2012).
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; CP003243; AFD01088.1; -; Genomic_DNA.
DR RefSeq; WP_014406919.1; NC_017034.1.
DR AlphaFoldDB; H8I4Z4; -.
DR STRING; 1041930.Mtc_2355; -.
DR GeneID; 11972530; -.
DR KEGG; mez:Mtc_2355; -.
DR eggNOG; arCOG00874; Archaea.
DR HOGENOM; CLU_008213_6_0_2; -.
DR OrthoDB; 11644at2157; -.
DR Proteomes; UP000005233; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd17926; DEXHc_RE; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.1170.30; -; 1.
DR Gene3D; 6.10.140.1180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR040699; XPB_DRD.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18458; XPB_DRD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:AFD01088.1};
KW Helicase {ECO:0000313|EMBL:AFD01088.1};
KW Hydrolase {ECO:0000313|EMBL:AFD01088.1};
KW Nucleotide-binding {ECO:0000313|EMBL:AFD01088.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005233}.
FT DOMAIN 80..223
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 313..446
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 446 AA; 50265 MW; C7B310275D129519 CRC64;
MIRLAYDKGT ILVYGNVRVP GSVWDTRAGA YRAPAYLYKD IRAYGESSGF TFRDDVLDLV
PSPELKMRTV LRDYQERAVS AWDRAGRWGV VVLPTGAGKT HVAMKAISMA NPAIVVVPTL
DLLAQWKERL EDEFGIDVGV YSGDEHSLGP VTVATYDTAY IRAAELGNRF LLAVFDEVHH
LPSTGYSTIA EMFACPARLG LTATYEREDG RHSELPRLVG GKVFEKSVES LKGEHLAPFE
LKRIYVRLTP EEEAQYQKDM EIYKNYLKEN HIILRTPRDF ERLVMRSGRD RHAREAILAR
HRARAVALNS SSKLEALADV LRKHSGDKVL IFTEHNELVY RISRQFLIPF ITYKTGGEER
SRNLAEFKAG NYRALVTSKV LDEGVDVPDA SVGIILSGSG SKREFVQRLG RILRKKGDKK
AVLYEIISGS TSEVKTSYRR HRGVDK
//
