ID H8IPM3_MYCIA Unreviewed; 10416 AA.
AC H8IPM3;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Linear gramicidin synthetase subunit D {ECO:0000313|EMBL:AFC44096.1};
GN OrderedLocusNames=OCU_28770 {ECO:0000313|EMBL:AFC44096.1};
OS Mycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384 /
OS NCTC 13025 / 3600).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=487521 {ECO:0000313|EMBL:AFC44096.1, ECO:0000313|Proteomes:UP000008004};
RN [1] {ECO:0000313|EMBL:AFC44096.1, ECO:0000313|Proteomes:UP000008004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600
RC {ECO:0000313|Proteomes:UP000008004};
RX PubMed=22535933; DOI=10.1128/JB.00295-12;
RA Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H.,
RA Kim B.J.;
RT "Complete genome sequence of Mycobacterium intracellulare strain ATCC
RT 13950T.";
RL J. Bacteriol. 194:2750-2750(2012).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP003322; AFC44096.1; -; Genomic_DNA.
DR RefSeq; WP_014380277.1; NZ_CP076382.1.
DR KEGG; mia:OCU_28770; -.
DR PATRIC; fig|487521.10.peg.2892; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_222740_0_0_11; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000008004; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19543; DCL_NRPS; 3.
DR CDD; cd19540; LCL_NRPS-like; 4.
DR Gene3D; 3.30.300.30; -; 9.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 7.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 11.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 6.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 11.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 8.
DR NCBIfam; TIGR01720; NRPS-para261; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 8.
DR Pfam; PF13193; AMP-binding_C; 8.
DR Pfam; PF00668; Condensation; 11.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 8.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 8.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 8.
DR SUPFAM; SSF47336; ACP-like; 8.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 22.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 8.
DR PROSITE; PS50075; CARRIER; 8.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 8.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 949..1023
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2854..2929
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3916..3991
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4973..5048
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6033..6107
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 7526..7601
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 8580..8654
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 10078..10153
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 10416 AA; 1111139 MW; 8947FA71EE6753ED CRC64;
MERGGDRALP VTRGQLDIWL AQQAGHFDAA WQLGVLVRID GAIDPRLLHQ AMRHVVNEAE
SLRASFFEAD GQVFQKAVDY DDVDLVFYDL TESPDPEREV RETAASIQRT PMPLTGPMIK
FALFRTGPDE YYWFTVCHHI AIDGMGIALT GRRIAAVYSA LAAGKPVPPA FFGSLHDLVS
GELEYEGSAK FREDQEYWVA HRPAGSGADY PAPALNDGRD PYSPSPPVQL DQSVVGRVKE
LSKTLGIRRS SVLTAACALL VRGWCADGSD EVVLDFPVSR RVDPESKTHP GMLAGVVPLV
LKAAPDTSFA DFCRHVDQRS REALRHQQFP TRTLDGEGGF NGPRQAPNRV VVNFVPARLT
LSLNGIPATA TYTSFGPVGH FGLFFLGFGD QQFLSTVGTG QPFSNFDVAD LAERLQRVLA
TMVADPSRRL ASLDVLRSAE RTRLEELGNK EVLNLPASAP MSVPELFATQ VARTPEAVAL
VCEGRSVTYR ELDEASNRLA HLLTGLGAGP GQTVALMFSR SPEAVASILA VLKTGAAYLP
IDPSSPESRI GFMLDDAKPV AALSTVDLAD RLDGHDVPVI DVNDSRIDAQ RADALPAPGP
DHVAYLIYTS GTTGVPKGVA VTHRNVTQLL GSLDAGLPPS GVWSQCHSYA FDVSVWEIFG
ALLRGGRLVV VPEDVTRSPD ELHDVLAGED VSVLTQTPSA VAMLSPERLS AASLVVVGEA
CPAEVVDRWA PGRVMVNAYG PTETTMCVAI SAPLTKGSGI PPIGSPVPGA ALFVLDGWLR
PVPPGVVGEL YVAGDGVTSG YVGRTGLTAS RFVACPFGGA GARMYRTGDL ASWGDDGQLQ
YLGRADEQVK IRGYRIELGE IQAALAALDG VDQAVVIARE DRPGDKRLVG YVTGIADPVE
ARAALAERLP GYMVPAAVVV LEALPLTPNG KLDIRALSTP EYTTGEYRAP GNAVEEILAG
IYAEVLGVQR VGVDESFFEL GGDSILSLQV VARARAAGLT CRPRDVFVEQ TVARLARVAG
VSDGAAQVVD EGVGPVPPTP IMRWLEGAEQ AGPVDQFNQT VMVQAPAGVT AADVSMVLQA
LVDRHAMLRL RVERDGTGGW SFHIPEPGSV WAQDCLQAVD ALTDDALLDA RSRLNPFTGA
MLSALWVEST GRLAVIIHHL AVDAVSWWIL LEDLNIAWAL HSAGQPVELP PAGTSFARWA
TMLNEHARHP DVVGQLNAWK RVTEAPAALP AARPDVDTYA SAGRLSVELD AETTAMLLGE
VPTAFHAGIQ DILLIAFGLA WAEFLGDTGA PIGIDVEAHG RHEELGADID LSRTVGWFTT
KYPVSLAVAG LRWAQVVSGD TALGPIIKDA KEQLRALPDP LTYGLLRYLN SDVDLAGPDP
SIAFNYLGRQ GAAPDSAGEG WSISQDGLSL IGAAAAVPMP LMHTVELNAG TIDTGAGPHL
HAEWTWAPSV LDATQITRLS RLWFEALSGV CAHVRNGGGG LTPSDIAPAR LSQQQIDELA
RRHHIADILP LTPLQQGLLF HSSTAQGGDD MYAVQLDFTL TGPLDPDRLR DAVHTVVKRH
PHLAALFCEQ FDEPVQIIPA DPVVEWRYLE LDDGGAGEAD ADARIERLCA AERAAVCDLA
GQAAFRAALI RTADRRFRFV LTNHHILLDG WSLPILLREI FASYYGQRLP AAGSYRAFLT
WLADRDLDAS REAWAELLSG LQTPTLVAPE DRLGQGRRGF EKSRVSAQTT RALGELARSH
HTTLSTVLQA AWALVLTSLT GQHDVVFGTP RSRVGQLEVD DAESMVGLLI NTVPVRANIT
ATTTTADLLA QLQNSHNDAL EHQHLALSEI HRVTGHDQLF DTLFVYENYP IDSGMTLGDD
GLAIAAFTNR EYNHYPLTVE ALPGRELGLH IEFDADVFDA ADIASLVERL QRVLVAMTAD
PARRLSSMDL LDRDERDLVL SRMSGAGVGA PVGVAPELLA AAVAAGPDAP AVIDGARALS
YRELDEWSTR LARKLIDAGV GPERAVGVAI GRCAELVVAW WAVVKAGGIY APVDLDHPVE
RIASVLDAVD AVCVLTCGTD DVAGAGTRPI VRLDGLDLSA CSAQEITDAD RLSPLRAGDT
AYLIFTSGST GVPKGVAVGH SGMLGWAAAQ RELFGLGSDA RVLMVASPTF DASVGELLLA
AGSGAALVVA PPQVYAGEAL TALLHDQRVS AAILTPTVIS TLDRARLDRL DTLVAVGEAC
LPELVDAWAP GRQMFNGYGP SETTIWVTCA RLSAGEPVRI GAPISGVCAR VLDAWLNPVP
VGVVGELYLS GPALGHGYLG RVELTAERFV ANPFGAPGTR MYRTGDLVRW MSDGTLDYLG
RADNQIKLRG QRIELGEIEN TLLACPQVTQ AAVTVADTAT GSHLVAYVTL DHNATTDRDL
QQDAEDVQEW QHLYDDLYGA DLAANFGEDF RGWNSSYTGE PIPLEEMVEW RSATVDRIMS
LRPRRVLEIG AGSGLLLSQI APHCDQYVAT DFSAVAIDNL ARAMERLQLP WRDRVELLTQ
PAHVTDGLPQ GHFDTIILNS VVQYFPNAGY LAQVIDKAME LLAPGGAVFI GDIRNHTLQG
AFQTAIALAR GDAADAAEIR QRVRHAMLGE TELLLAPEFF TSWARSRPEA VGIDIRVKRG
MADNELNRHR YDVAIHKAPA AVRSVADEPT LTWAQCNGLR GLRETLTSRR PPAVRITDIP
RAGLITDVGV EGALAQGLPL ADALAQADAG PDATVAEELH RLGERAGYGV AVTWGAQPGT
LSAVFIASAD QAFPALTDLY VAPDGARRRT IHANDPRTNT KVGEVRERLS AWLPEYMVPT
HIVALEEFPM TTSGKLDRKA LPAPDYQDAD RYRAPATAVE EILVGIYAQV LGLERVGVDD
SFFDLGGDSL SAMRLIAAVN TSFNSDLGVR AVFEAPTVAE LALLTSGDAD RPDPLVAGER
PAVIPLSFAQ TRLWFIDQFQ GASPMYNITV ALRLRGHLDA DALAAALADV VGRHETLRTV
FASADGIPQQ VVVPAERIGF ACDVIDARGW PQDRLRESME TAARYTFDLS HESPLHTELF
TVSDDEHMLV VAVHHIAADG WSITPFARDL GIAYASRCAG QAPDWTPLAV QYVDYTLWQR
AHLGDVDDRD SRIAAQLDYW ADALAGLPER LQLPTDRPYP QVADHRGARL AVDWPAELQQ
QVRRVAREHN ATSFMVIQAA FAALLAKISA STDVAVGFPI AGRPEPALDD LIGFFVNTLV
LRVDLGELGG DPTFAELLGQ VRRRSLAAFE HQDVPFELLV ERLNPTRSMA HHPLVQVLLG
WENFPGEVTA PAAGLALGDL RVTPMPLHTN TARMDLTFSL AERFTESGQR AGIAVTAEYR
TDVYNADTVE AMIDRLQRLL AAVTADPERR LSSVDLLDTA EHARLAQWGN QAVLSERMEP
VTVAGLFAAQ AARTPDAVAL TFEDRSMTYR ELDEAANRLA HVLVDRGAGP GAFVALLFSR
SAEAIVAILA VLKSGAAYLP IDPALPAARV EFMLTDAAPM AAVTTADLAD RFDGFDLIVV
DVADPAVAAQ PSTPPPAPAP TDLAHVIYTS GTTGVPKGVA VTQHNVAQLF DDLRLGIALS
AEQVWTQFHS YAFDFSVWEI WGALLHGGRL VVVPDAVARS PEEFHALLVR EGVTVLTQTP
SAVGLLSPQG LDGTALVIGA EPCPPELVDR WAPGRVMVNV YGPTETTMWA CKSAPLTAGS
GFPPIGSPVS WAAFFVLDEW LRPVPAGVVG ELYLAGEGVG VGYWRRPGLT ASRFLACPFG
EPGTRMYRTG DLVRWGRSGS GEGQLQYLGR ADEQVKVRGY RIELGEIRAA LSALDGVEQA
VVVAREDRPG DKRLVGYITG TAEPARARAA VAERLPAYMV PAAVVVLDAL PMTVNGKLDA
RALPAPDYQG GNGYRAPSTA IEEILAGIYA GVLGVERVGV DDSFFDLGGD SLSTMRLITA
INTTLETELP VRVVFEAPTV AQLAPRIAES SGRLEPLVAG ERPAIIPLSF AQNRLWFIDQ
FQGPSPLYNM AAALRLRGRL DAHALGAALA DVVSRHESLR TLFPSHEGTP RQEVVPAERA
EFGWEVVDAT AWPTSRLDDA VKSVTRHAFD LAAEIPIRAR LFTITEDEHL LVIAVHHIAA
DGMSLTPLGA DLSLAYTSRS AGRAPDWADL PVQYIDYTLW QRAQLGDLDD GDSRIGAQLA
YWERALAGMP ERLELPTDRP YPAVADQRGD SVVVDWPAEL QQQVRRVARE HNATSFMVVQ
AALAVLLSKV SASPDVAVGF PIAGRRDPAL DQLVGFFVNT LVLRVDLAGD PSFAELLDRV
QAQSLAAFEH QDVPFEVLVE RVNPTRSLTH HPLVQVMLAW QNFAGHDDPA AGLALGDLEV
TSVPVEDQSA RMDLVFSLAE RWTERGEAAG IGGRVEFRTD VFDATTVEAL IGRLQRVLTA
MTADPAHPLS SVDLLDEAEH ARLKELGNHA VLTRPAGDVP ASIPALFAAQ AARAPESVAL
VCGDLSVTYR ELDEASNRLA HCLASAGAGP GQVVALLFSR SAEAVASILA VLKTGAAYLP
IDPSSPDARI EFMLGDAKPV AAVTTADLAE RLDGRGVTII DVNDPRVDTL PDTALPAPGP
DHLAYLIYTS GTTGVPKGVA ITHRNVTQLL GSLDAGLPAA GVWSQCHSLA FDVSVWEIFG
ALLRGGRLVV VPEAVAASPH DLHDVLVAQQ VSVLTQTPSA VAMLSREGLD SVSLVMAGEA
CPAEVVDQWA PGRVMVNAYG PTETTMCVTI SAPLAAGMGP VPIGSPVPGA ALFVLDDALR
PVPPGVVGEL YVAGSGVAAG YVGRAGLTAS RFVACPFGGA GTRMYRTGDL VRWERSGSGV
GQLLCLGRAD EQVKIRGYRI ELGEIQSALA GFDGVAQAVV VAREDRPGDK RLVGYVTGSA
DLTQLRAALG ERLPAFMVPA AVVTLDAIPL TPNGKLDARA LPAPEYTAGR YRAPETLTEE
ILAGVYAGVL GVERVGVDDS FFDLGGDSIS AMRLVAAINA SLDAGLPVRA VFEAPTIAQL
APRIGEGGSG LEPLTAAERP AVIPLSFAQN RLWFLDQLQG PSPVYNMAAA LRLDGPLDAD
ALGAALGDVV VRHESLRTVF VAPEGLPQQV VIPAGKADFG WEVVDAGTWS ADQLDEAIGA
TARYTFDLSA QIPLRAELFR IRDDRHVLVA VVHHIAADGM SLTPLVRDLG VAYAARCDGR
GPDWSPLSVQ YVDYTLWQRA QFGDLDDSDS RIAAQLAYWE EALAGMPERL PLPTDRPYPL
VADQRGATVE IDFSAELQQR VADVARRHNA TSFMVVQTAL MVLLSKISAS SDVAVGFPIA
GRRDPALDEL VGFFVNTLVL RVDLENLGGD PTFAELLSQV RHRSLAAYEH QDVPFEVLVE
RLNPARSLSH HPLVQVMLAW QNFAGQESGP AAGLALGDVD VTPIPVDTHT ARMDLTFSMG
ERWSDAGESA GIGGTVEFRT DVFDADSIAA LIGRLQRVLL AMTADPAQAL SAVDLLDDAE
HARLDALGNR TALTGPATET ESIPALFAAQ AARTPDTAAV VCDGHSMTYR ELDEASNRLA
HLLAARGAGP GQAVALLFSR SAEAIVAILA VLKTGAAYLP IDPALPAERI GFMLSDAAPI
ATLASPGLAD RLEGHDVTVI AVDDPELEDR PATALPAPGP DHLAYLIYTS GTTGVPKGVA
VTHRNVTQLL ASKDSGLPRT GVWSQWHSLA FDVSVWEIFG ALLHGGRLVV VPESVARSPE
DLHALLVAER VSVLSQTPSA AGALAPAGLE SVALVVAGEA CPAELVDRWA PGRVMINAYG
PTEATVYAAI SAPLQAGTGA VGPVPIGSPV PNGASFVLDE WLRPVPPGVV GELYVAGAGV
ACGYWKRAAL TASRFVACPF GAPGSRMYRT GDLVRWRADG QLDYLGRADE QVKIRGYRIE
LGDVRAALSW VAGVEQAVVV AREDRPGDKR LVGYVTGTAD PAAVRAALAE RLPGYMIPAA
VVVMQALPLT PNGKLDTRAL PAPEYSDADQ YRAPDNAVEE ILAGIYAQVL GLERVGVDDS
FFDLGGDSIS SMQVVTRARA AGLVCKTRDI FVEQTVARLA RVAEVVDADA AVLDEGVGPV
AATPIIRWLQ DVESVGGQVD QFNQAMLVQA PAGVTEADVV TMLQALLDRH PMLRLRVDGS
GVQGSGDWSL TVPEAGSVDA ADCLHVVDEL SDAAVTEARS RLNPAAGVML SALWAGATGQ
LVVIVHHLAV DGVSWRILLQ DLNIAWAQHH SGRPVELPAA GTSFARWSSR LAQHARRPDV
VDQAERWTEV AATPPALPAV RPDMDTFATA GHLFMELDPE TTGALLGEVP SAFHAGVQDI
LLIAFALACA EFGGGRAPIG IEVEGHGRHE ELGRDIDLSQ TVGWFTTKYP TALNVRGVSW
GQVVTGGTAL GAALKDAKEQ LRALPDPLTY GLLRYLNPGI DLDGPEPPIG FNYLGRQGGA
GELTADMWRP VPDGWSVTRA AASTAMPLMH TLELNAATVD SADGPRLHAN WTWAPSALDD
EQVARLGRLW FAALAGICAH VRSGGGGLTP SDIAPARLSQ QQLDQLARQH RIADVLALTP
VQQGLLFHAN TAPATDDLYA GQLNISIAGP LDPNRLRDAV HTVVSRHPNL VARFCDRYDE
PVQIIPADPA PAWRYLELDG TDTDAIERLC AAERAAVCGD LAEQPAFRVA LVRTASERYR
LVLTNHHIVL DGWSLPILLG EIFAAYYGQR LPAAAPYRSF VSWLADRDLD AARAAWGQVF
AGFDTPTLVG AQDRTELGRQ SVESFALPAD LTQAVADLAR SCHTTVNTVL QAAYAQLLCG
LTGQRDVVFG TTVSGRPAEI AGADTMVGLL INTVPVRANI GAATTTADLL DQLQGAYNHT
LDHQHLALNE IHRITGQDAL FDTLFAYENY PIDASALSGN HELAVTDITS RESTHYPLTV
QAQPGREMRL QVEYDTDVFD AARIATLIER LRRVLAAMTA DPARRLSSID LLEPAEHDRL
DAWGDRAILT QPGTPASIPE LFTAQAARTP HAPAVTYEGR SMTYRELDES SNRLAHLLID
RGVGPGESVA LLFGKSADAI VAILAVLKTG AAYLPIDPAL PAARIEFMLG DTAPMAALTV
AALADKLDGH HLMVIDIHDR AVARQPVTAL PAPAPEHVAH IIYTSGTTGV PKGVAVSHHN
VTRLFDAQAV GVELSADQVW TQFHSYAFDF SVWEIWGALL HGGRLVVVPD SVARSPMDFH
ALLVAEKVTV LSQTPSAVRM LSPQGLDAAA LVIGAEPCPP ELVDRWAPGR VMVNVYGPTE
ATIFSSTSTP LSAGSGAPPI GSPVPGAGLF VLDGWLRPVP AGVVGELYVA GRGVGYGYWK
RSGLTASRFV ACPFGEPGSR MYRTGDLVRW GTDGQLQYLG RADEQVKIRG YRIEVGEVRS
ALAALDGVDQ AVVVAREDRP GDKRLVGYIT GPADPAGARA ELAERLPAYM VPVAVVALDA
LPMTVNGKLD TRALPAPEYS AAGYRSPTTP TEEILAGIYA HVLGVERVGV DDSFFDLGGD
SISAMRVIAA INSAMDTGVP VRVIFEAPTV AQLAPRIGED TGRLDPLVAG ARPAVIPLSF
AQSRLWFLDQ LQGPSPVYNM AAALRMHGRL DAHALGAALA DVVARHESLR TVFAAPQGTP
QQVVLPAERA DLSWRMVDAR GWSAGRLREA IDIAAAETFD LATQIPLRAS LFRVAEDEHV
LVAVVHHIAA DGWSLRPLVR DLGMAYASRS AGRAPDWEPL PVQYVDYTLW QRDQFGELAD
SGSRIAEQLA YWQEALAGMP ERLQLPTDRP YPQIADQRGA AVEVDWPADL QQQVAGLARE
YNSTSFMVVQ AALAVLLSKI SASTDVAVGF PIAGRRDPAL DELVGFFVNT LVLRVDLAGD
PSFTDLLARV RARSLEAFEH QDVPFEVLVE RVNPARSLSH HPLVQVMLAW QNFAGQDGDP
GAGLALGDVR VTSIPLDTQV ARMDLVFSLA ERWTDGDEPA GIGGRVEFRT DVFDADSIRA
LIRRLERVLT AMTADPTRPM SSVDLLDAAE HARLDALGNR AVLTAPATQA GSIPALFAAQ
AARTPDAVAL SFEGRSWTYR ELDEAANRLA HRLAGFGVGP GERVALLFGR SADAIVAILA
VLKSGAAYLP IDPGLPAERI GFMLSDAAPM AAISTGELAA RLRGHHVVVL DVNDPAIDAQ
PATALPAPDA DDIAYLIYTS GTTGVPKGVA VSHRNVAQLL AAQDLGLPRE GVWSQWHSLA
FDVSVWEIFG ALLHGGRLVV IPDSAVRSPR DFHALLVDER VSVISQTPSA AGVLSPEGLE
SATLVVAGEA CPTELVDAWA PGRAMINAYG PTEATVYAAV SAPLKAGSNV VPIGSPVPGA
GLFVLDESLR PVPQGVVGEL YVAGAGVACG YWKRSGLTAS RFVACPFGAP GSRMYRTGDL
VCWGSDGQLQ YLGRADDQVK VRGYRIELGE VRSALAALDG VDQAVVIARE DRPGDKRLVG
YVTGAADPAQ LRARLGDRLP AYMVPAAVVA LDALPLTPNG KLDARALPSP EYTDADRYRA
PQTPVEETLA GIYAQVLGVE RVGADDSFFD LGGDSISSMQ VVTRARAAGL AVRTRDIFTE
QTVARLARVA VAADGEDGVV DEGTGAITAT PIIRWLRGVE SAGGPVDQFN QTMVLQAPAG
VTEADVVTVL QALLDRHAML RLRVDRHSDD DAGEWSLQVP EPGSVDAAHR VLSVDELTDA
AVVEARSRLN PAAGVMLSAL WVAPTGQLVL IVHHLAVDGV SWRVLLEDLN IAWGQHHHGQ
PVALPTGGTS FARWASLLAE RAHVPAVTER AEAWRRVAAT PPALPAVRPG LDTYETAENL
SVLLDVETTR TLLGEAPAAF HAGINDILLA GFALAWAEFL GNAGAPIGID VEGHGRDEEL
AAGVDLSRTV GWFTAKYPVA LNVGGLSWAD VVAGAPILGA LLKDAKEQLR ALPDPLTYGL
LRYLNDEVDL DGSDPTIGFN YLGRLGGAAA ELSDELWRIS RDGAAATAAS TAVPMPLMHT
VDLNAGTMDT EDGPQLHATW TWAPSALDRE QVARLSTLWF QALAGICAHV RDGGGGLTPS
DIAPARLNQP QIDQLERIHR VADVLPLTPL QEGLLFHATT MRGSDDHLYV VQLDLSLAGP
IDRDRLRDAM HAVITRHPHL VARFSDRFDE PVQIIPADPA MAWRYLEVAA NGSEPEEQIQ
RLCAAEREAV YDLADEPAVR AVLIRTGQDR HRLVLTIHHI VLDGWSVPIL LNETFACYTG
QRLPAPPPYR RFVAWLAERD RDAAREAWAG VFDGFDTPTL VGPPHQPEPG ARGVQSFAVP
AGITAALGEL ARSSHTTVST VLHAAWAQLL AWLTGQHDVA FGTTVSGRPA DVPGADAMVG
LMINTVPVRA RIAAATTAAD LLAQLQGAHT ETLDHQHLAL SEIHRITGQD KLFDTLFAYE
NYPLDTSAMA VDHELGITDV NMFERNHYPL TMQAALSGEE LGLRVEYDAA VFDAHTIGAL
GERFERVLVA MTADPARPLS SVDLLDGSEH ARLDEVGNRA VLARAPLEFP SIPALFDAHV
AGTPDAVAVS WGDLSMTYRE LDDAANRLAH LLTGHGAGPG QAVALLFSRS PQAIVAILAV
LKTGAAYLPI DPAAPATRIR FMLEDSAPVA AVTTTGLRSR LDGCDVTVID IEDAPTDTAA
GTPLPAPPPD GIAYIIYTSG TTGVPKGVAI THRNVTQLLE PLDAGLPRAG VWTQSHSYAF
DVSVWEIFGA LLRGGRLVVV PESVARSPRD FHDLLAAERV SVLTQTPSAV AMLSHEGLES
VSLVMAGEAC PPEVVDRWAP GRVMVNAYGP TETTMCVAIS APLTAGSGTP PIGSPVDGAA
LFVLDGWLRP VAAGVVGELY VAGDGVAAGY VGRPGLTASR FVACPFGAPG SRMYRTGDLV
CWTTDGQLQY LGRADEQVKI RGYRIELGEV QTALAALEDV DQAVVIARED RPGDKRLVGY
ITGTADPGEA RTALAQRLPG YMVPAAVVGL DALPLTPNGK LDTRALPAVQ YTGSGYRAPS
NALEEALAAA FARVLGVQRV GADDSFFDLG GDSISAMRLV AAINTGLGAD LPVRTLFDAP
TVAGLGQRLC TPTTDAHEVV PVQTLKQGAG GVPLFCVHPA GGVSWPYQVL GNHLDCPIIG
IQQVPRNGDG GPRSIRAMAQ TYADRIQHAY PDGPYNLLGW SFGGVVAHEV AIELQRRGCE
IGRLILLDAQ PGLDGGMAVG EHAQGEQRVL EEVLRANNIG PGEQDGHADE RRPRSKPLVA
QLLSNLNDNI ELYRRHEPGR FEGEITVFSA ARDDGDRGAR LSRSWAPYAS GHIAVHAIDC
THHDMLTAES VATYGERLRD LLGATMRATS HSRRSQ
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