ID H8K989_RICAC Unreviewed; 609 AA.
AC H8K989;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN ECO:0000313|EMBL:AFC70609.1};
GN OrderedLocusNames=MC5_01000 {ECO:0000313|EMBL:AFC70609.1};
OS Rickettsia australis (strain Cutlack).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=1105110 {ECO:0000313|EMBL:AFC70609.1, ECO:0000313|Proteomes:UP000007589};
RN [1] {ECO:0000313|Proteomes:UP000007589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cutlack {ECO:0000313|Proteomes:UP000007589};
RA Johnson S.L., Munk A.C., Han S., Bruce D.C., Dasch G.A.;
RT "Complete genome sequence of Rickettsia australis strain Cutlack.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; CP003338; AFC70609.1; -; Genomic_DNA.
DR RefSeq; WP_014412151.1; NC_017058.1.
DR AlphaFoldDB; H8K989; -.
DR STRING; 1105110.MC5_01000; -.
DR KEGG; rau:MC5_01000; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_2_5; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000007589; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}.
FT DOMAIN 212..330
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 423..567
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 609 AA; 68907 MW; CBD02979194205B9 CRC64;
MTIKFLSENT INRIAAGEVI ERPASVVKEL VENAVDAGST KIDIILERAG KNLIIISDDG
IGMTDKELEI AVERHTTSKL DESDFLNIHT FGFRGEALPS IAAISKMLIT SKKQGADKAF
QIKLIGGNEK QVTISVHNEG TKIEIRDLFF ATPARLKFLR ADKTELVATV DVVKKIALAH
PEIFFSLTHD DRNLLKFKGQ NKDAETNLKQ RIIDVIGDDF IKNAAYIDFK TPDFSICGYT
SIPTYNRASS EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPLCAIF LQIDPHLVDV
NVHPAKAEVR FHDPNYVRNL LIEAIKNALT NTSHVTSTTI ASDALQLFKN HLVNKQPSVS
KAVSVNSKPT DYRHAMSPSF KSTPNTACQK LIDTLPHAKI EQEVERRIEH EQQAHKQYKL
GAAKAQLHTT YIISQTEDSI VITDQHAAHE RLGYEKIKDY LKTEELIKQR LLIPEIVELP
NERKADCLYE NREKLYKLGL TLEKFGEKSI IVTEIPNILG DVNVQKLIQD LADHLSDFGE
NIALTELIEH VTETYACHYS IRAGRKLSTD EMNALLRQME NTPFSGQCNH GRPTYIELKL
KDIERLFGR
//
