ID H8WXZ0_CANO9 Unreviewed; 280 AA.
AC H8WXZ0;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Transcription initiation factor IIE subunit beta {ECO:0000256|PIRNR:PIRNR016398};
GN ORFNames=CORT_0A05500 {ECO:0000313|EMBL:CCG20937.1};
OS Candida orthopsilosis (strain 90-125) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=1136231 {ECO:0000313|EMBL:CCG20937.1, ECO:0000313|Proteomes:UP000005018};
RN [1] {ECO:0000313|EMBL:CCG20937.1, ECO:0000313|Proteomes:UP000005018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=90-125 {ECO:0000313|Proteomes:UP000005018};
RX PubMed=22563396; DOI=10.1371/journal.pone.0035750;
RA Riccombeni A., Vidanes G., Proux-Wera E., Wolfe K.H., Butler G.;
RT "Sequence and analysis of the genome of the pathogenic yeast Candida
RT orthopsilosis.";
RL PLoS ONE 7:e35750-e35750(2012).
CC -!- FUNCTION: Recruits TFIIH to the initiation complex and stimulates the
CC RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase
CC activities of TFIIH. Both TFIIH and TFIIE are required for promoter
CC clearance by RNA polymerase. {ECO:0000256|ARBA:ARBA00025581,
CC ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SUBUNIT: Tetramer of two alpha and two beta chains.
CC {ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SIMILARITY: Belongs to the TFIIE beta subunit family.
CC {ECO:0000256|PIRNR:PIRNR016398}.
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DR EMBL; HE681719; CCG20937.1; -; Genomic_DNA.
DR RefSeq; XP_003866377.1; XM_003866329.1.
DR AlphaFoldDB; H8WXZ0; -.
DR GeneID; 14536905; -.
DR KEGG; cot:CORT_0A05500; -.
DR eggNOG; KOG3095; Eukaryota.
DR HOGENOM; CLU_056580_2_0_1; -.
DR OrthoDB; 2786543at2759; -.
DR Proteomes; UP000005018; Chromosome 1.
DR GO; GO:0005673; C:transcription factor TFIIE complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR InterPro; IPR040501; TFA2_Winged_2.
DR InterPro; IPR016656; TFIIE-bsu.
DR InterPro; IPR003166; TFIIE_bsu_DNA-bd.
DR PANTHER; PTHR12716:SF8; TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA; 1.
DR PANTHER; PTHR12716; TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT; 1.
DR Pfam; PF18121; TFA2_Winged_2; 1.
DR Pfam; PF02186; TFIIE_beta; 1.
DR PIRSF; PIRSF016398; TFIIE-beta; 1.
DR PROSITE; PS51351; TFIIE_BETA_C; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR016398};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR016398};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR016398};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR016398}.
FT DOMAIN 65..139
FT /note="TFIIE beta"
FT /evidence="ECO:0000259|PROSITE:PS51351"
FT REGION 27..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 280 AA; 31211 MW; 72E7FF04E8CE3DAE CRC64;
MSDLSAQLSA FKNKLKSGPS VAVARKAVIS KPGSPLPTTP SNSSNTPSKR PNPTDPAIDV
YKRHKPERAD LSGSHLSTQL HLAVEYIKEQ DHPVSIGKLQ QTLSFDVEHT LLPLLKEIDR
VKYDETSRTL VYVSLHNIKT ADDLLEFLRK QTTFKGVSVK ELKDGWAGCY QAIDDLEAED
KILVLRNKKE NAPRLVWANA GGKVGAISDE FKKMWVDVKL PEPDVLYQSL IDQGLKPTGA
DPSLVNKIPQ QQEKKQKKAR RGKITNTHMK GILKDYSQLV
//
