ID H9CXV7_SCHMD Unreviewed; 453 AA.
AC H9CXV7;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS Schmidtea mediterranea (Freshwater planarian flatworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC Dugesiidae; Schmidtea.
OX NCBI_TaxID=79327 {ECO:0000313|EMBL:AFD29628.1};
RN [1] {ECO:0000313|EMBL:AFD29628.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CIW4 {ECO:0000313|EMBL:AFD29628.1};
RX PubMed=22385657; DOI=10.1016/j.stem.2012.01.016;
RA Wagner D.E., Ho J.J., Reddien P.W.;
RT "Genetic Regulators of a Pluripotent Adult Stem Cell System in Planarians
RT Identified by RNAi and Clonal Analysis.";
RL Cell Stem Cell 10:299-311(2012).
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DR EMBL; JQ425160; AFD29628.1; -; mRNA.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24418:SF421; INACTIVE TYROSINE-PROTEIN KINASE WSCK-RELATED; 1.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..453
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003618847"
FT DOMAIN 26..124
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 319..453
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 346
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 453 AA; 52681 MW; D487715F30A54E4D CRC64;
MIKFNSSHFY WFIFIVEIVN GMFDFPSTDS CYEIRTFESK LSKLEYQTAR LSCHINVIKR
CRKGSVRWAW FKDNIQIKNG TQKKTRSQIY IEHLIYNTTM SDTGEYHCLV QNNVFNYSQY
VNLSVSVGTP ELKVIRLNTV PLNISVLEEK RTYWMPKMTT ELYEISYKFE LSNTYRLQCQ
FFSLAKLNIS SVRWYGSLGH VNNRDRRTFG ELIKTGXXYE IKTIPYNCNQ EKFLNIKNGT
CYDSDFKINP YSKLYKYYTC AIGGQLNRTH QIDVKNYIFR QVDLSNEKLR FTGNSTICAG
QKFIFNCSTE KEIPRNHVKV SGVKLGEGNF GTVFLGSVDS RDVAIKIPTE QGQDMLFDEV
RMMQQIGRHR HVLELIGLCF DEGSLWAIME LASGGSLKNY LQSCNPLINH PCQEINLNQL
FTYTLQIGKG MNYLSSKSVI FFYHLQIISL SKL
//
