ID H9F5N6_MACMU Unreviewed; 728 AA.
AC H9F5N6;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Rho guanine nucleotide exchange factor 26 isoform 1 {ECO:0000313|EMBL:AFE69945.1};
DE Flags: Fragment;
GN Name=SGEF {ECO:0000313|EMBL:AFE69945.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFE69945.1};
RN [1] {ECO:0000313|EMBL:AFE69945.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Caudate {ECO:0000313|EMBL:AFE69945.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
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DR EMBL; JU326189; AFE69945.1; -; mRNA.
DR AlphaFoldDB; H9F5N6; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11938; SH3_ARHGEF16_26; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035797; ARHGEF16/ARHGEF26_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12845:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 296..480
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 512..639
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 646..707
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFE69945.1"
SQ SEQUENCE 728 AA; 82295 MW; 30EFA09682AAE747 CRC64;
LRSPRTPNAP APCTPEEDPT GLNASPVPSP TANGLAANND SPRSGSQSGQ KAKEPERGLS
SAPQKSSSEQ KLPLQRLPSQ ENELLENPSV VLSTNSPAAL KVGKQQIIPK SLASEIKISK
SNNQNVEPHK RLLKVRSMVE GLGGPLGHAG EESEFDNDVD SPGSLRRGLR STSYRRAVVS
GFDFDSPTSS KKKNRMSQPV LKAVMEDKEK FSSLGRIKKK MLKGQGTFDG EENAVLYQNY
KEKALDIDSD EESEPKEQKS DEKIVIHHKP LRSTWSQLSA VKRNGLSQTV SQEERKRQEA
IFEVISSEHS YLLSLEILIR MFKNSKELSD TMTKTERHHL FSNITDVCEA SKKFFIELEA
RHQNNIFIDD ISDIVEKHTA STFDPYVKYC TNEVYQQRTL QKLLATNPSF KEVLSRIESH
EDCRNLPMIS FLILPMQRVT RLPLLMDTIC QKTPKDSPKY EVCKRALKEV SKLVRLCNEG
ARKMERTEMM YTINSQLEFK IKPFPLVSSS RWLVKRGELT AYVEDTVLFS RRTSKQQVYF
FLFNDVLIIT KKKSEESYNV NDYSLRDQLL VESCDNEELN SSPGKNSSTM LYSRQSSASH
LFTLTVLSNH ANEKVEMLLG AETQSERARW ITALGHSSGK PPADRTSLTQ VEIIRSFTAK
QPDELSLQVA DVVLIYQRVS DGWYEGERLR DGERGWFPME CAKEITCQAT IDKNVERMGR
LLGLETNV
//
