ID H9F9F2_MACMU Unreviewed; 886 AA.
AC H9F9F2;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
DE Flags: Fragment;
GN Name=OCRL {ECO:0000313|EMBL:AFE71261.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFE71261.1};
RN [1] {ECO:0000313|EMBL:AFE71261.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Caudate {ECO:0000313|EMBL:AFE71261.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type II family. {ECO:0000256|ARBA:ARBA00005910}.
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DR EMBL; JU327505; AFE71261.1; -; mRNA.
DR AlphaFoldDB; H9F9F2; -.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052745; F:inositol phosphate phosphatase activity; IEA:InterPro.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09093; INPP5c_INPP5B; 1.
DR CDD; cd13382; PH_OCRL1; 1.
DR CDD; cd04380; RhoGAP_OCRL1; 1.
DR Gene3D; 2.30.29.110; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR037793; OCRL1/INPP5B_INPP5c.
DR InterPro; IPR037787; OCRL1_PH.
DR InterPro; IPR031995; OCRL_clath-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR047078; RhoGAP_OCRL1.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF176; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF16726; OCRL_clath_bd; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}.
FT DOMAIN 706..886
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 150..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFE71261.1"
SQ SEQUENCE 886 AA; 102612 MW; 806F820613BB078E CRC64;
EGMEMKGPLR EPCALTLAQR NGQYELIIQL HEKEQHVQDI IPINSHFRCV QEAEETLLID
IASNSGCKIR VQGDWIRERR FEIPDEEHCL KFLSAVLAAQ KAQSQLLVPE QKDSSSWYQK
LDTKDKPSVF SGLLGFEDNF SSMNLDKKIN SQNQPTGIHR EPPPPPPLVN KMLPREKEAS
NKEQPKVTNT MRKLFVPNTQ SGQREGLIKH ILAKREKEYV NIQTFRFFVG TWNVNGQSPD
SGLEPWLNCD PSPPDIYCIG FQELDLSTEA FFYFESVKEQ EWSMAVERGL HSKAKYKKVQ
LVRLVGMMLL IFARKDQCRY IRDIATETVG TGIMGKMGNK GGVAVRFVFH NTTFCIVNSH
LAAHVEDFER RNQDYKDICA RMSFVVPNQT LPQLNIMKHD VVIWLGDLNY RLCMPDANEV
KSLINKKDLQ RLLKFDQLNI QRTQKKAFVD FNEGEIKFIP TYKYDSKTDR WDSSGKCRVP
AWCDRILWRG TNVNQLNYRS HMELKTSDHK PVSALFHIGV KVVDERRYRK VFEDSVRIMD
RMENDFLPSL ELSRREFVFE NVKFRQLQKE KFQISNNGQV PCHFSFIPKL NDSQYCKPWL
RAEPFEGYLE PNETVDISLD VYVSKDSVTI LNSGEDKIED ILVLHLDRGK DYFLTISGNY
LPSCFGTSLE ALCRMKRPIR EVPVTKLIDL EEDSFLEKEK SLLQMVPLDE GASERPLQVP
KEIWLLVDHL FKYACHQEDL FQTPGMQEEL QQIIDCLDTS IPETIPGSNH SVAEALLIFL
EALPEPVICY ELYQRCLDSA HDPRICRQVI SQLPRCHRNV FRYLMAFLRE LLKFSEYNSV
NANMIATLFT SLLLRPPPNL MARQTPSDRQ RAIQFLLGFL LGSEED
//
