ID H9FHK1_MACMU Unreviewed; 551 AA.
AC H9FHK1;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator-like 2 isoform 1 {ECO:0000313|EMBL:AFE74110.1};
DE Flags: Fragment;
GN Name=RGL2 {ECO:0000313|EMBL:AFE74110.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFE74110.1};
RN [1] {ECO:0000313|EMBL:AFE74110.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Caudate {ECO:0000313|EMBL:AFE74110.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
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DR EMBL; JU330354; AFE74110.1; -; mRNA.
DR AlphaFoldDB; H9FHK1; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF363; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 2: Evidence at transcript level;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 40..164
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 195..465
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 531..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFE74110.1"
FT NON_TER 551
FT /evidence="ECO:0000313|EMBL:AFE74110.1"
SQ SEQUENCE 551 AA; 60259 MW; 07E9D3C518340EBD CRC64;
EEEEAPVSVW DEEEDGAVFT ITSRQYRPLD PLVPMPPPRS SRRLRAGTLE ALVRHLLDTR
TSGTDGTFMS AFLATHRAFT STPALLGLMA DRLEALESHP TGELERTTEV AISVLSTWLA
SHPEDFGSEA KGQLDRLESF LLQTGYAAGK GVGGGSADLI RNLRSRVDPQ APDLPKPLAL
PGDPPADPTD VLVFLADHLA EQLTLLDAEL FLNLIPSQCL GGLWGHRDRP GHSHLCPSVR
ATVTQFNKVA GAVVSSVLGA TSTGEGPGEV TIRPLRPPQR ARLLEKWIRV AEECRLLRNF
SSVYAVVSAL QSSPIHRLRA AWGEATRDSL RVFSSLCQIF SEEDNYSQSR ELLVQEVKLQ
SPLEPHSKKA PRSGSRGGGI VPYLGTFLKD LVMLDAASKD ELENGYINFD KRRKEFAVLS
ELRRLQNECR GYNLQPDHDI QRWLQGLRPL TEAQSHRVSC EVEPPGSSDP PAPRVLRPTL
VISQWTEVLG SVGVPTPLVS CERPSMAGDE VPTTPAPLLT RLAQHMKWPS VSSLDSALES
STSLHSPADP S
//
