ID H9G959_ANOCA Unreviewed; 1254 AA.
AC H9G959;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 {ECO:0000313|Ensembl:ENSACAP00000004399.3};
GN Name=RAPH1 {ECO:0000313|Ensembl:ENSACAP00000004399.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000004399.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000004399.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000004399.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000004399.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H9G959; -.
DR STRING; 28377.ENSACAP00000004399; -.
DR Ensembl; ENSACAT00000004500.4; ENSACAP00000004399.3; ENSACAG00000004500.4.
DR eggNOG; KOG3751; Eukaryota.
DR GeneTree; ENSGT00940000156552; -.
DR HOGENOM; CLU_267159_0_0_1; -.
DR InParanoid; H9G959; -.
DR TreeFam; TF317511; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000004500; Expressed in forelimb bud and 12 other cell types or tissues.
DR GO; GO:0031252; C:cell leading edge; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16136; RA_MRL_Lpd; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF15; RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 328..414
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 455..564
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..712
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..787
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..815
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..849
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..905
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..963
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..999
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1083
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1130
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1179..1222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1254 AA; 136020 MW; FAFF185A2ABBF242 CRC64;
MEQLSDEELD HGAEEDSDKE DQDLDKMFGA WLGELDKLTQ SLDTDKPMEP VKRSPLRQET
NIANFSYRFS MYNLNEALNQ GEAVDLDALM ADLCSIEQEL SSIGSQSANS MSMKRFAADG
KMAQKPPGSV RVAAKHSSMK GLSSSSSSRA TKPSHAIFSL DDITAQLEKA SLSMDEAAQQ
PVMEDSKPIV ATQHRRTASA GTVSDAEVRS ISTSSRSSIT SAASSMDSLD IDKVTRPQEL
DLTQQGQPVS EHIVSMEHSS KQARRHIDFS EEEAELAPHS YLDRETSLLL RNIAGKPSHL
LTKEEQAAKL KAEKIRVALE KIKEAQVKKL VIRVHMSDDS SKTMMVDERQ TVRQVLDNLM
DKSHCGFSLD WSLVETISEL QMERIFEDHE NLVENLLNWT RDSQNKLMFV ERIEKYALFK
NPQNYLLGKR ETSEMADRNK EVLLEECFCG SSVTVPEIEG VLWLKDDGKK SWKKRYFLLR
ASGIYYVPKG KAKVSRDLVC FLQLDHVNVY YGQDYRNKYK APTDYCLVLK HPQIQKKSQY
IKYLCCDDIR TLHQWVNGIR IAKYGKQLYV NYQEALKRTE SAYDWTSLSS SSIKSGSSSS
SLPESQSNHS NQSDSGLSDT QTGHVRSQSI VSSIFSEAWK RGTQLEESSK ISARMDSMNR
PFPSFAPPLS PQTKTAAPFT ASQPSPPLPP PPPPPPPPPP PPPPPPPPLP SQSLSSGAGS
ATVFVKYSTI TRLQNAAQHG GLLFKPPLMM HQATPLPPPG KPQNLLPPNG VIPPPPPPPP
PPTPGSAMAQ LMKPVPSAPS VPQFTPPPPP APPLKIHQVH QSIPQPTASP PPPPAIPAPP
PPQAPPKPAM TLPTQNSTKA ASPVVAHPTP PAPLPSAVKK QPSFTMPPAP LSPVPLGPTP
PPTLPKQQNY SSKLPPSPQS PVPSVVKQIA SQFPPPPLPV SEPQPLKPAP LSVPPPSPPA
VKAKPKWQPT SAPSPDFPPP PPESSLAFPP PPSPSPLVVS PTPDKTGGSP VKKAGKSSSP
GGKKPPPTPQ RNSSIKSNSS AEYHESKRPS VDSLVSKFAH PPEPSGSPSK ESPNPPAAPP
KPGKLTLPIA LQQAGISAKT PGKGAVEEFP SPPSDSDFPP PPPEIDLPLP PVEIPAVFSG
NTSPKVAVVN PQPQPWSKSS MKKAPPPTRP KRNDSTRLTQ AEMAEAQVTT ASPQVPTSPK
SSLSVQPGFL ADLNRTLQRS PSPATAPSPP PGYPEQSQWQ PWMTWLCLHP HLNF
//
