ID   H9G9T4_ANOCA            Unreviewed;       494 AA.
AC   H9G9T4;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=Cytochrome P450 2G1-like {ECO:0008006|Google:ProtNLM};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000004918.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000004918.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000004918.3};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000004918.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR   AlphaFoldDB; H9G9T4; -.
DR   STRING; 28377.ENSACAP00000004918; -.
DR   Ensembl; ENSACAT00000005031.4; ENSACAP00000004918.3; ENSACAG00000005050.4.
DR   eggNOG; KOG0156; Eukaryota.
DR   GeneTree; ENSGT00940000157162; -.
DR   HOGENOM; CLU_001570_22_3_1; -.
DR   InParanoid; H9G9T4; -.
DR   TreeFam; TF352043; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000005050; Expressed in kidney and 9 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008392; F:arachidonic acid epoxygenase activity; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IBA:GO_Central.
DR   GO; GO:0019373; P:epoxygenase P450 pathway; IBA:GO_Central.
DR   GO; GO:0006805; P:xenobiotic metabolic process; IBA:GO_Central.
DR   CDD; cd11026; CYP2; 1.
DR   Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR008067; Cyt_P450_E_grp-I_CYP2A-like.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PANTHER; PTHR24300:SF384; CYTOCHROME P450; 1.
DR   PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR01684; EP450ICYP2A.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; Cytochrome P450; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000461};
KW   Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   494 AA;  56659 MW;  BE1E0F8D199D6E95 CRC64;
     MNNLFSMELQ GVLTILLGIC LIFVAAWKWK HKEGRFPPGP MPLPFFGNLL QLNPKDTLKS
     LLTLRDKYGP VYTLYLGPRR VVVLCGHDVL KEALVDCGEQ FSGRGEMATL DQTCRGFGFA
     FSNGERWKKL RHFSLITLKN FGMGKCSIEE RIQEESQYLL EKFRKTHGLP FDPTFLLSCT
     TSNIICSIVF GSRFEYEDKT FLYLLDVINK AFYEMSTPWA QMYEMYSGIM QHLPGGHKRL
     YNLLEELNTF IAERIKINQE TLDPKNPRDF IDCFLIEMEK EKGDPSTEFT MTNLIITVLN
     LFFAGTETIS STLRYLFLLM LKYPEVEEKV HQEIDCVVGR NRIPAVKDRV NMPYTNAVIH
     EIQRLVDILP VGLPHKVTED IEFRGYLLPK DTNIITLLGS ALHDPQYFSD PEIFNPEHFL
     DEEGHFKKID AFVPFSAGKR ACVGEPMARM ELFLYFTTIL QNFAVKSSQG SQGHGHLSPN
     KVLCKDLSLF TSLC
//