ID H9GBV8_ANOCA Unreviewed; 502 AA.
AC H9GBV8;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Tripartite motif containing 69 {ECO:0000313|Ensembl:ENSACAP00000006605.3};
GN Name=TRIM69 {ECO:0000313|Ensembl:ENSACAP00000006605.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006605.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000006605.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006605.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000006605.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Neurotoxin that produces dose-dependent hypolocomotion and
CC hyperalgesia in mice. May directly act on the central nervous system,
CC as it is 6500-fold more potent when administered
CC intracerebroventricularly than intraperitoneal.
CC {ECO:0000256|ARBA:ARBA00034460}.
CC -!- SIMILARITY: Belongs to the ohanin/vespryn family.
CC {ECO:0000256|ARBA:ARBA00009651}.
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DR AlphaFoldDB; H9GBV8; -.
DR STRING; 28377.ENSACAP00000006605; -.
DR Ensembl; ENSACAT00000006751.4; ENSACAP00000006605.3; ENSACAG00000006744.4.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160707; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; H9GBV8; -.
DR TreeFam; TF342569; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000006744; Expressed in lung and 6 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0071539; P:protein localization to centrosome; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF286; E3 UBIQUITIN-PROTEIN LIGASE TRIM69; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Neurotoxin {ECO:0000256|ARBA:ARBA00022699};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Toxin {ECO:0000256|ARBA:ARBA00022699};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 44..83
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 305..502
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 176..254
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 502 AA; 57907 MW; B3FA6CC9F1FE2CFF CRC64;
MSSTTSKNPS TSSFASIHER PIFQGPSDTS WELHADDFTK ELSCGVCLEL FKNPVILSCG
HNFCKDCLED LWKKKGIFCP QCHASVPDRK YISNTALEKM ADRIKTYHVG CLQQKCIEHS
EPLTLYWKPQ EKLACFTCRE TMLPKEQCTQ FLLIPDAVQI FTEKLLMMRI QLRSILVKLE
VLKNAQEEKI SNHKENKLQL QYHISLEFLK LHQFLHSKEK ELINQLKEES EILLQEMEAN
INRLQDRTQS AKDTLVCIQA RLYQQNSASF LRGIRLFIER MEQRTENSAL GELVTGTLST
GVFKSPVHYA VWKEMKSILY PDISFLTLDP KTAHPNLILS EDLTCVSHGD TKKTVQDTPE
RFDCSVSVLG SEGFTTGKHY WEVEVKNKTK WTLGVVKESI NRKGNYPLSP KEGHWLIKLR
NRNDFKAVDV QPKNLTLENI PTRIGVLVDY EGGQVSFYDT NQMVHIYTFM DTFCEKLYPY
FCPCLNDAGE NSQPLKIINY YM
//
