ID H9GE03_ANOCA Unreviewed; 1446 AA.
AC H9GE03;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=P-type Cu(+) transporter {ECO:0000256|ARBA:ARBA00012517};
DE EC=7.2.2.8 {ECO:0000256|ARBA:ARBA00012517};
GN Name=ATP7A {ECO:0000313|Ensembl:ENSACAP00000008362.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000008362.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000008362.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000008362.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000008362.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
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DR STRING; 28377.ENSACAP00000008362; -.
DR Ensembl; ENSACAT00000008543.4; ENSACAP00000008362.3; ENSACAG00000008542.4.
DR eggNOG; KOG0207; Eukaryota.
DR GeneTree; ENSGT00940000159568; -.
DR HOGENOM; CLU_001771_0_1_1; -.
DR TreeFam; TF300460; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000008542; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IBA:GO_Central.
DR GO; GO:0043682; F:P-type divalent copper transporter activity; IBA:GO_Central.
DR GO; GO:0140581; F:P-type monovalent copper transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0055070; P:copper ion homeostasis; IBA:GO_Central.
DR CDD; cd00371; HMA; 6.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 6.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006122; HMA_Cu_ion-bd.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR NCBIfam; TIGR00003; copper ion binding protein; 5.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 6.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00942; CUATPASEI.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 6.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 6.
DR PROSITE; PS50846; HMA_2; 6.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}; Transport {ECO:0000256|ARBA:ARBA00022796}.
FT TRANSMEM 660..679
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 711..733
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 754..775
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 781..803
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 892..916
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 936..959
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1308..1333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1339..1359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 8..74
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 171..237
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 278..344
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 377..443
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 494..560
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 570..636
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 460..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1446 AA; 156795 MW; F971E414C58C182B CRC64;
MDPASGARSV VISVEGMTCN SCVETIEAHI SKLNGVLSIK VSLRDKSAAI IYNPKEQAPG
ALREAIEDMG FVAALTDADP QPVSVDTVFL TIPAHAALAL DEIRSRLLTT KGVLNVKSSS
DKKSLVVTFV SAVINGKQVG QAVPGLSLDH AARERNPGAP EDASASQTGD VALRIKVEGM
TCHSCTSTIE GKIGKLQGVT RIKVSLDNQE AVVVYQPHII TAEEIRNQIE AAGFLASIKK
PPKLLNLGAI DVERLKNVQT KSSPKSPPES PEDGFNLQTA RFRVDGMHCK SCVFNIQSSI
SMLPAVASID VSLEDRSATV KYDPSLISIT TLGRAIEAVS PETFTVSLCD GHENAELSNA
PKSPRVANSP AHHPLMHVTV MDVEGMTCHS CVQSIEGVIS QKPGVNSVHV SLQNRNATIE
YDPMQTSPDD LRNAIEDMGF DASLTGTPSP DPVVLITQPS QERMVESQNN KLSKTETRTK
PSPLHDNQDG NPPSKCYIQV TGMTCASCVA NIERNLKREE GIFSVLVALM AGKAEVRYNP
AVIQPPIVAE LIRELGFGAT VLENYDQGDG VLELVVKGMT CASCVHKIES TLMKTKGVLY
SSVALATNKA HIKYDPEIIG PRSIMRVVED LGFKSALVKK DRSASHLDHK QEIRQWKRSF
LVSLFFCIPV MGLMIYMMVM DSHMSAMHNA GNVTQGDMEE HHSAMFLEQQ ILPGLSVMNL
LSFLLCVPVQ IFGGWHFYIQ AYKALKHRTA NMDVLIVLAT TIAFIYSLVV VLVAMAERAK
VNPVTFFDTP PMLFVFIALG RWLEHIAKGK TSEALAKLIS LQATEATVVT LGPDNILLSE
EQVDVELVQR GDIIKVVPGG KFPVDGRVIE GHSMVDESLI TGKQKVNYSY GYFVPFIVGV
SVLTLFAWIV IGFVDFEIVE TYFPGYNKSI SKAEVVIRFA FQASITVLCI ACPCSLGLAT
PTAVMVGTGV GAQNGILIKG GEPLEMAHKV KIVVFDKTGT ITHGTPVVMQ LKMLVESNRM
PRNTILALVG TAESSSEHPL GTAITKYCKQ ELDTETLGTC TDFQVVPGCG IRCKVTNIES
LIYRRSESLE ENNVRNAALV NIDDGEPMRP ALIIDEQLPT TWNPHKYSVL IGNREWMSRN
GLHVKNDVDH AMTEHERRGR TAVLVAVDGE LCGLVAIADT VKPEAELAVR TLKAMGLEVI
LMTGDNSKTA RSIASQVGIS KVFAEVLPSH KVAKVKQLQD EGKRVAMVGD GINDSPALAM
ASVGIAIGTG TDVAIEAADV VLIRNDLLDV VASIDLSRKT VRRIRINFVF ALIYNLVGVP
VAAGVFLPIG LVLQPWMGSA AMAASSVSVV LSSLLLRLYR KPNSEEYERR ARGQLRQKSP
SEVSVHIGID ESGPESPKLS LMDRIINYSR SSINSFLSDK RSRSSIVLSD PDKHSLLVGE
EYDTTL
//