ID   H9GI04_ANOCA            Unreviewed;       376 AA.
AC   H9GI04;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Alcohol dehydrogenase 7B {ECO:0000313|EMBL:CCP94580.1};
GN   Name=LOC100553136 {ECO:0000313|Ensembl:ENSACAP00000011468.2};
GN   Synonyms=ADH7B {ECO:0000313|EMBL:CCP94580.1};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000011468.2, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000011468.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000011468.2};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CCP94580.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Borras E., Albalat R., Duester G., Pares X., Farres J.;
RT   "The Xenopus alcohol dehydrogenase gene family.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000011468.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; HF569256; CCP94580.1; -; Genomic_DNA.
DR   RefSeq; XP_003225794.1; XM_003225746.3.
DR   STRING; 28377.ENSACAP00000011468; -.
DR   Ensembl; ENSACAT00000011707.4; ENSACAP00000011468.2; ENSACAG00000028771.2.
DR   GeneID; 100554830; -.
DR   KEGG; acs:100554830; -.
DR   eggNOG; KOG0022; Eukaryota.
DR   GeneTree; ENSGT00940000164026; -.
DR   HOGENOM; CLU_026673_14_0_1; -.
DR   OMA; WKMKDSI; -.
DR   OrthoDB; 1077476at2759; -.
DR   TreeFam; TF300429; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000011737; Expressed in embryo and 10 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004024; F:alcohol dehydrogenase activity, zinc-dependent; IBA:GO_Central.
DR   GO; GO:0004745; F:NAD-retinol dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR   GO; GO:0006069; P:ethanol oxidation; IBA:GO_Central.
DR   GO; GO:0042573; P:retinoic acid metabolic process; IBA:GO_Central.
DR   GO; GO:0042572; P:retinol metabolic process; IBA:GO_Central.
DR   CDD; cd08299; alcohol_DH_class_I_II_IV; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR43880:SF8; PKS_ER DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          19..374
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   376 AA;  40034 MW;  21EF5FC40798B5AB CRC64;
     METTGKIIKC KAAVAWEIGK PLSIEEIEVA PPKSHEVRVK IIATGICGTD DHVLSGSFPK
     VNYPVIPGHE GAGIVESVGE GVTGLNPGDK VIPLCLPQCG ECSSCLKSNT NCCLKTHLNE
     PQNLMPDKTS RFTCKGKLIH HFLWISTFSE YTVMPDSTVV KIDAAAPLDK VCLFGCGFST
     GYGAALNTAQ VMPGSTCAIF GLGGVGLSVV MGCKAAGASR IIGIDINKDK FLKAKELGAT
     ECLNPQDYKK PIQELLVEMT GHGVDYAFEV VGCLDTLTAA LASCHLGCGV CVMVGVPPLG
     SRLTFDPMLL FTGRTLKGCF IGGWKMKDSI PQLVSSYMEK KFNSDALISH TLPFSQISEG
     FNLLHSGKSI RIVLVF
//