ID H9GIS7_ANOCA Unreviewed; 824 AA.
AC H9GIS7;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000012109.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012109.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000012109.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012109.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000012109.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H9GIS7; -.
DR STRING; 28377.ENSACAP00000012109; -.
DR Ensembl; ENSACAT00000012354.3; ENSACAP00000012109.3; ENSACAG00000012200.3.
DR eggNOG; KOG1082; Eukaryota.
DR GeneTree; ENSGT00940000156002; -.
DR HOGENOM; CLU_005790_3_0_1; -.
DR TreeFam; TF106443; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000012200; Expressed in hemipenis and 13 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046974; F:histone H3K9 methyltransferase activity; IBA:GO_Central.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd20905; EHMT_ZBD; 1.
DR CDD; cd10535; SET_EHMT1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043550; EHMT1/EHMT2.
DR InterPro; IPR047762; EHMT_CRR.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR038035; SET_EHMT1.
DR PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR PANTHER; PTHR46307:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF21533; EHMT1-2_CRR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT REPEAT 294..326
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 327..359
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 360..393
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 394..426
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 460..492
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 582..645
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 648..765
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 172..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 824 AA; 91818 MW; 6707E2DFD877DCA1 CRC64;
MEYMEVSLDS LDLRVKGILS PQSEGLSNGP EAAEADSLQE VPLCSCRMET PKSREITTLA
NNQCMATESI DKELSRCTNR VLKYELMRPS NKVQLLVLCE DHRGRMVKHQ CCPGCGFFCA
AGTFMECQPE SSISHRFHQD CASQVKGTSY CPHCGEEASK AKEVTVAKAD TTSTLPQSYE
QKKPSVSEGR ADTTTGSGIV TQTSEEARLE NSSSEGFDLA GTSSFPKPAP PGLPQGPVKE
TLESALIALD SEKPKKLRFH SKQLYFSARQ GELQKVLLML VDGIDPNFKM EHQNKRTPLH
AAAESGHVDV CHMLIQAGAN IDTCSQDQRT PLMEAAENNH LETVKYLIKA GALVDPKDAE
GSTCLHLAAK KGHYDVVQYL LTNEEMDVNC QDDGGWTPMI WATEYKHVEL VKLLLAKGSD
INIRDNEENI CLHWAAFSGC VDIAEILLAA KCDLHAVNIH GDSPLHIAAR ENRYECVVLF
LSRGSDVTLK NKEGETPLQC SSLNSQVWVA LQMNKTLKES SPDKPVQLEK TLSKDIARGY
ERIPIPCINA VDSEPCPTNY KYVSQNCVTS PMNIDRNITH LQYCVCIDDC SSSKCMCGQL
SMRCWYDRDG RLLPEFNTAE PPLIFECNHA CSCWRTCRNR VVQNGLRARL QLFRTRNMGW
GVRTMQDIPL GTFVCEYVGE LISDSEANVR EEDCYLFDLG NKDRDVYCID ARFYGNISRF
INHFCEPNLI AVRVFMSHQD LRFPRIAFFS SRHIQAGEEI GFDYGERFWN IKGKYFSCLC
GSPKCRHSSA ALAQRLASPS LSPEASENRL PDTSSTVAAA STPF
//
