ID H9GST8_ANOCA Unreviewed; 1163 AA.
AC H9GST8;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Cation-transporting ATPase {ECO:0000256|RuleBase:RU362082};
DE EC=7.2.2.- {ECO:0000256|RuleBase:RU362082};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000019659.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000019659.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000019659.2};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000019659.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|RuleBase:RU362082};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362082}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU362082}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type V subfamily. {ECO:0000256|RuleBase:RU362082}.
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DR AlphaFoldDB; H9GST8; -.
DR STRING; 28377.ENSACAP00000019659; -.
DR Ensembl; ENSACAT00000027308.2; ENSACAP00000019659.2; ENSACAG00000024961.2.
DR eggNOG; KOG0208; Eukaryota.
DR GeneTree; ENSGT00940000160327; -.
DR HOGENOM; CLU_001828_0_0_1; -.
DR InParanoid; H9GST8; -.
DR TreeFam; TF300331; -.
DR Proteomes; UP000001646; Unplaced.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140358; F:P-type transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015203; F:polyamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:1902047; P:polyamine transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006544; P-type_TPase_V.
DR InterPro; IPR047819; P5A-ATPase_N.
DR NCBIfam; TIGR01657; P-ATPase-V; 1.
DR PANTHER; PTHR45630:SF4; CATION-TRANSPORTING ATPASE 13A5-RELATED; 1.
DR PANTHER; PTHR45630; CATION-TRANSPORTING ATPASE-RELATED; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF12409; P5-ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00121; NAKATPASE.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362082};
KW Magnesium {ECO:0000256|RuleBase:RU362082};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362082};
KW Metal-binding {ECO:0000256|RuleBase:RU362082};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362082};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU362082};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362082};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362082}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 181..198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 204..223
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 377..399
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 411..436
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 876..898
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 904..923
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 944..966
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1011..1028
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1040..1060
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT TRANSMEM 1080..1101
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362082"
FT DOMAIN 1..120
FT /note="P5B-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12409"
FT DOMAIN 138..190
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00690"
FT REGION 1131..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1163 AA; 130825 MW; 127388566AA6352A CRC64;
MEIFGYRTQV FRRALCIAGY LFSCGALLLL FYWKPEWDVW ANCTPCDLEE ADIVLLRATD
EFQRYKRKKV ISLDLQRLLD SEKPEQLFSE DQESVINRAI ARPGGKVRYI QVQKIRYVWD
VPGKAFVRVG SLEDSNTCYQ IHQKFRDGLT RRQRDLRKLV CGPNAIEIEI RPIWKLLFKE
ILNPFYVFQA FTLTLWLAQG YIEYSIAIII LSIISIGLTV YDLRQQSVKL HNLVEEHNKV
QVKVWTKPEG GHQSESCHLV PGDVLLLEGQ KLSLPCDAIL LDGSCVVNEG MLTGESVPVT
KTPLPQADNV QPWKKHSLED HRRHVLFCGT EVIQTRPSGK GPARAVVLQT GFNTAKGDLV
RSILYPKPMN FRLYKEAFLF IVGLVIIGLI GLVYAAAVFG SRGRPVSDTV AMALLLLTVA
VPPAIPAALT TGIVYAQRRL KKKKIFCISP QRINICGQIN MVCFDKTGTL TEDGLDLWGA
IPCQEQSFLP LHSFSSGPLP WGPLCQAMAT CHSLLFLEGR IQGDPMDLKM FEGTGWEMQE
TCSEEKETGE TEAFTIVKPG ATASQAPSEG MSILHQFPFS SSLLRMSVVT KELGKDTHGL
YMKGAPETVA SFCHPKTVPS SFQEELKSFT AQGFRVIALA HKVLSLDAED SLRDLDRDEV
ESGLTLLGLL VMENRLKGET RPVLEELRDA RIRTVMVTGD NLETAVTVGR NSGMIPLGDR
VILVEAADPE GPQPASVTWQ VMEDMQSCKE KNQDPCISID GSSTSFHFAM NGKTFQVLQK
YFSPLLPKIL VNGTVFARMS PGQKSNWWEF LLLLLLKSCG LVLPPLQALK MAHAGISLSE
QEASVASPFT SQTPNIQCVP ELIREGRASL VSSFAVFKYL TIYGLTQFIG TALLYWQLQI
FGNYQYLIQD VCITLVVCLT MSLTEAYPKL APYRPPGRLL SPSLLLSVFL NVCFTLVVQI
FAFLFVRQQP WYSPIRSHRG CPLGNEPFLL GNGTGNATEP EDTVLSYEDT SLWPLVTIYC
IIVAFVFSKG KPFRKPIYTN YIFSTFLCIQ LGLSLFLFFA DIEAIYKGLM LLCTPTIWRI
YILIMLLVKF GVSYFVEDAI LQNHRLWLWI KALLRFRSSS KYRKLQRQLQ RDPSWPPLNQ
RDFAEDRKGE AYTNPVFENS EGD
//
