ID H9H042_HORSE Unreviewed; 1043 AA.
AC H9H042;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Dynein 2 intermediate chain 1 {ECO:0000313|Ensembl:ENSECAP00000023086.4};
GN Name=DYNC2I1 {ECO:0000313|Ensembl:ENSECAP00000023086.4,
GN ECO:0000313|VGNC:VGNC:25008};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000023086.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000023086.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000023086.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000023086.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000023086.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H9H042; -.
DR STRING; 9796.ENSECAP00000023086; -.
DR PaxDb; 9796-ENSECAP00000023086; -.
DR Ensembl; ENSECAT00000028947.4; ENSECAP00000023086.4; ENSECAG00000026867.4.
DR VGNC; VGNC:25008; DYNC2I1.
DR GeneTree; ENSGT00390000013743; -.
DR HOGENOM; CLU_010610_0_0_1; -.
DR InParanoid; H9H042; -.
DR OMA; ILNMWVV; -.
DR TreeFam; TF329081; -.
DR Proteomes; UP000002281; Chromosome 4.
DR Bgee; ENSECAG00000026867; Expressed in oviduct epithelium and 23 other cell types or tissues.
DR GO; GO:0097546; C:ciliary base; IEA:Ensembl.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IEA:Ensembl.
DR GO; GO:0031021; C:interphase microtubule organizing center; IEA:Ensembl.
DR GO; GO:0000242; C:pericentriolar material; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0045504; F:dynein heavy chain binding; IEA:InterPro.
DR GO; GO:0045503; F:dynein light chain binding; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:Ensembl.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR042505; DYNC2I1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR16022:SF0; CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 1; 1.
DR PANTHER; PTHR16022; WD REPEAT DOMAIN 60; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REGION 1..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 119743 MW; AD0EA16913BC5EA1 CRC64;
MEPGKRRSKD DTWKADDLRR HLWVAHSGSP KEDKKHREKL PPKESEMDVP EYKEHRHREP
DGDTKYRERM AERDGHPSRE PARGERDREK PRERRKDARD QDRGKLKEKH REQDAEKAHR
RGKDREKDQD RRARREELRQ AAAYHNLLGR DVRGWQVLER AERKVPAVSK VRIEEKERRD
EDSERGDEER ERRYRERKLQ YGDSKDNPLK YWLYKEEGER RHRKQKEPDR EKKHREKSST
REKKEKYSKE PRTPSSDKEG EERHKEKRHS EGFRLDDERH RGSVDKKERP SKEEPRKREY
KNGEHRSQGT SSKRDGTSNQ HAENLVRNNG RDKDARRKEI EKEDIDLENG GADEYIASFE
DDCEDYEDDF EVCDGDDDDS TNEPELREKV QELPLARKKE IQEIQKAISA ENERIGELSL
KLSQKQGLMD RERASRPDAN NSSSRAPVCG IFMDFATASH RQRSRTQAFK QKTRSTKLLR
LIDLDFSYTL SLLDLPPVNE YDMYIRNFGK KNTKQAYVQY NEDHVERDVQ TEEIETREAW
TQHPGEGTAV SGGSGSTDSS DAAAVPKVDT PRLSSFLRAA CQVIAVLLEE DRVAAEPSWS
PRMQDNTLPF SDRSSQLNTS LPFLQNRKVS CLHASQVQRQ TVVSVHGVAE KAFAPVLDDK
YVLCVWDIWQ PSGPQKVLIC ESKVTCCCFS PFKAFLLFAG TMHGSVVVWD LREDSRIHQY
VKLSDCFWTF RTSTFSTDGV LTSVNHRSPL QAIEPISASV YKKQSFVLSP FSTQEEMSGL
SFHIASLDQS GVLNMWVVVE LPKADVAGSI SDLGLIPGGR IKLVHSAVIQ LSDSLSHKGY
EFWGTTQTLN IKFLPSDPNH FIVGTDIGLI SHGTRQDLRV SPKLFKPQQH GMRPVKVNVI
DFSPFGEPTF LAGCSDGSIR LYQLTSEYPL MQWNNSTGGR AVTSLQWSLT RPAVFLVQDD
ASCVYVWDLL KSDLGPVAKQ PVSPDRLVAM TVMGEPEKTS GSFLALVLAR ASGGVDIQFL
KQEWATPVGN EQRKLHLLLQ EAM
//
