ID   H9MZL7_9REOV            Unreviewed;       172 AA.
AC   H9MZL7;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=NSP4 {ECO:0000313|EMBL:AFB81887.1};
DE   Flags: Fragment;
OS   Rotavirus A.
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Rotavirus.
OX   NCBI_TaxID=28875 {ECO:0000313|EMBL:AFB81887.1};
RN   [1] {ECO:0000313|EMBL:AFB81887.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RotaA/Human-wt/TUN/P145/2006/G2P[4]
RC   {ECO:0000313|EMBL:AFB81887.1};
RX   PubMed=22406141; DOI=10.1016/j.meegid.2012.02.011;
RA   Ben Hadj Fredj M., Zeller M., Fodha I., Heylen E., Chouikha A.,
RA   Van Ranst M., Matthijnssens J., Trabelsi A.;
RT   "Molecular characterization of the NSP4 gene of human group A rotavirus
RT   strains circulating in Tunisia from 2006 to 2008.";
RL   Infect. Genet. Evol. 12:997-1004(2012).
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DR   EMBL; JF344753; AFB81887.1; -; Genomic_RNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.430; -; 1.
DR   HAMAP; MF_04091; ROTA_NSP4; 1.
DR   InterPro; IPR002107; Rotavirus_NSP4.
DR   Pfam; PF01452; Rota_NSP4; 1.
DR   SUPFAM; SSF58030; Rotavirus nonstructural proteins; 1.
PE   3: Inferred from homology;
KW   Activation of host autophagy by virus {ECO:0000256|ARBA:ARBA00023050};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Enterotoxin {ECO:0000256|ARBA:ARBA00022861};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00023050};
KW   Membrane {ECO:0000256|SAM:Phobius}; Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   COILED          82..109
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFB81887.1"
SQ   SEQUENCE   172 AA;  19976 MW;  A03E13E66E10FC1D CRC64;
     FTDLNYTLSV ITLMNSTLHT ILEDPGMAYF PYIASVLTVL FTLHKASIPT MKIALKTSKC
     SYKVVKYCIV TVLNTLLKLA GYKEQITTKD EIEKQMDRVV KEMRRQLEMI DKLTTREIEQ
     VELLKRIYDK LIVRSTDETD MTKEINQKNV RTLEEWESGK NPYEPKEVTA AM
//