ID H9XQ40_PHYIN Unreviewed; 147 AA.
AC H9XQ40;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=orotate phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00011971};
DE EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
DE Flags: Fragment;
GN Name=UMP {ECO:0000313|EMBL:AFH01351.1};
OS Phytophthora infestans (Potato late blight agent) (Botrytis infestans).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4787 {ECO:0000313|EMBL:AFH01351.1};
RN [1] {ECO:0000313|EMBL:AFH01351.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=T30-4 {ECO:0000313|EMBL:AFH01351.1};
RA Garcia Bayona L., Restrepo S., Zimmernann B.;
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFH01351.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=T30-4 {ECO:0000313|EMBL:AFH01351.1};
RA Garavito M., Vasquez J.J., Lozano G., Bernal A.;
RT "Towards a new control strategy of Phytophthora infestans by inhibition of
RT de novo pyrimidine biosynthesis: the big picture.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AFH01351.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=T30-4 {ECO:0000313|EMBL:AFH01351.1};
RX PubMed=24361203; DOI=10.1016/j.gene.2013.12.009;
RA Garcia-Bayona L., Garavito M.F., Lozano G.L., Vasquez J.J., Myers K.,
RA Fry W.E., Bernal A., Zimmermann B.H., Restrepo S.;
RT "De novo pyrimidine biosynthesis in the oomycete plant pathogen
RT Phytophthora infestans.";
RL Gene 537:312-321(2014).
CC -!- FUNCTION: Catalyzes the transfer of a ribosyl phosphate group from 5-
CC phosphoribose 1-diphosphate to orotate, leading to the formation of
CC orotidine monophosphate (OMP). {ECO:0000256|ARBA:ARBA00003769}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC family. PyrE subfamily. {ECO:0000256|ARBA:ARBA00006340}.
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DR EMBL; JQ087259; AFH01351.1; -; Genomic_DNA.
DR AlphaFoldDB; H9XQ40; -.
DR VEuPathDB; FungiDB:PITG_09576; -.
DR UniPathway; UPA00070; UER00119.
DR GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR HAMAP; MF_01208; PyrE; 1.
DR InterPro; IPR023031; OPRT.
DR InterPro; IPR004467; Or_phspho_trans_dom.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR NCBIfam; TIGR00336; pyrE; 1.
DR PANTHER; PTHR46683; OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED; 1.
DR PANTHER; PTHR46683:SF1; OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
PE 3: Inferred from homology;
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW Transferase {ECO:0000313|EMBL:AFH01351.1}.
FT DOMAIN 5..103
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00156"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFH01351.1"
FT NON_TER 147
FT /evidence="ECO:0000313|EMBL:AFH01351.1"
SQ SEQUENCE 147 AA; 15501 MW; 64A32CF974A3A9BA CRC64;
DSGVKFDVLF GPAYKGITLA AAVAIAYADM YGVDLPFAYN RKEAKDHGEG GVLVGADMTG
KKVLIIDDVI TAGTAIREAF GILEKTNAQV SGVCISLDRQ EKVSIEDTRS AIDQVRESFG
IPVVSIATLD NLVGYLETVD TATDANA
//
