ID H9ZFY7_MACMU Unreviewed; 1703 AA.
AC H9ZFY7;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 08-NOV-2023, entry version 41.
DE SubName: Full=Cullin-7 isoform 2 {ECO:0000313|EMBL:AFH34853.1};
GN Name=CUL7 {ECO:0000313|EMBL:AFH34853.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFH34853.1};
RN [1] {ECO:0000313|EMBL:AFH34853.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thymus {ECO:0000313|EMBL:AFH34853.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR EMBL; JU478049; AFH34853.1; -; mRNA.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021097; CPH_domain.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22771; CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22771:SF3; CULLIN-7; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF11515; Cul7; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
DR PROSITE; PS51284; DOC; 1.
PE 2: Evidence at transcript level;
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 819..998
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 1220..1511
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 84..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1349..1364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1703 AA; 191345 MW; 1939AC198E3FD8DA CRC64;
MVGERHAGDL MVPLGPRLQA YPEELIRQRP GHDGHPEYLI RWSVLKCGEV GKVGVEEGKA
EHILMWLSAP EVYANCPGLL GERALSKGPQ HEPAGVSGSF PRDPGGPDEV AMGEMEADVQ
ALVRRAARQL AESGTPSLTA AVLHTIHVLS AYASIGPLTG VFRETGALDL LMHMLCNPEP
QIRRSAGKML QALAAHDAGS RAHVLLSLSQ QDGIEQHMDF DSRYTLLELF AETTSSEEHC
MAFEGIHLPQ IPGKLLFSLV KRYLCVTSLL DQLNNSPELG AGDQSSPCAT REKSRGQREL
EFSMAVGNLI SELVRSMGWA RNLSEQGMSP PRPTRSIFQP YISGPSLLLP TIVTTPRRQG
WVFRQRSEFS SRSGYGEYVQ QTLQPGMRVR MLDDYEEISA GDEGEFRQSN SGVPPVQVLW
ELTGRTYWVH WHMLEILGFE EDVEDMVEAD EYQGAVASRV LGRALPAWRW RPMTELYAVP
YVLPEDEDTE ECEHLTLAEW WELLFFIKKL DGPDHQEVLQ ILQENLDGEI LDDEILAELA
VPIELAQDLL LTLPQRLNDS ALRDLINCRV YKKYGPEALA GHSAYPSLLE AQQDVLLQAQ
AQVKDSEDAA KVEAKEPPSQ SPNTPLQHLV EDYGPAGKIL LDLEQALSSE GTQENKVKPL
LLQLQRQPQP FLALMQSLDT PETNRALHLT VLRILKQLVD FPEALLLPWH EAVDACMACL
RSPNTDREVL QELIFFLHRL TSVSRDYAVV LNQLGARDAI SKALEKHLGK LELAQELRDM
VFKCEKHAHL YRKLITNILG GCIQMVLGQI EDHRRTHRSI NIPFFDVFLR YLCQGSSVEV
KEDKCWEKVE VSSNPHRASK LTDHNPKTYW ESNGSAGSHY ITLHMHRGVL VRQLTLLVAS
EDSSYMPARV VVFGGDSTSC ISTELNTVNV MPSASRVILL ENLNRFWPII QIRIKRCQQG
GIDTRIRGLE ILGPKPTFWP VFREQLCRHT RLFYMVRAQA WSQDMAEDRR SLLHLSSRLN
GALRQEQNFA DRFLPDDEAA QALGKTCWEA LVSPVVQNIT SPDEDGVSPL GWLLEQYLEC
QEAVFNPQSR GPAFFSRVRR LTHLLVHVEP CEAPPPVAAT PRPKGRNRSH DWSSLATRGL
PSSIMRNLTR CWQAVVEKQV NNFLTSSWRD DDFVPRYCEQ FNILQNSSSE LFGPRAAFLL
ALQNGCAGAL LKLPFLKAAH VSEQFARHID QQIQGSRIGG AQEMERLAQL QQCLQAVLIF
SGLEIATTFE HYYQHYMADR LLGVVSSWLE GAVLEQIGPC FPNRLPQQML QSLSTSKELQ
RQFHVYQLQR LDQELLKLED TEKKIQVGHR DSGKEYKSEK EEGAGAAAAV DVTEGEEEEE
ENEDLYYEGA MPEVSVLVLS RHCWPVASIC HTLNPRTCLP SYLRGTLNRY SNFYNKSQSH
PALEQGSQRR LQWTWLGWAE LQFGNQTLHV STVQMWLLLY LNDLKAVSVE SLLALSGLSE
DMLNEAIGPL TSSRGPLDLH EQKDIPGGVL KIRDGSKEPR SRWDIVRLIP PQTYLQAEGE
EGRNLEKRRN LLNCLIVRIL KAHGDEGLHI DQLVCLVLEA WQKGPCPPRG LVSSLGRGSA
CSSTDVLSCI LHLLGKGTLR RHDDRPQVLT YAVPVTVMEP HTESLNPGSS GPNPPLTFHT
LQIRSRGVPY ASCTATQSFS TFR
//
