ID HA2D_PIG Reviewed; 255 AA.
AC P15981;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 24-JAN-2024, entry version 104.
DE RecName: Full=SLA class II histocompatibility antigen, DQ haplotype D alpha chain;
DE Flags: Precursor;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2298465; DOI=10.1007/bf00702489;
RA Hirsch F., Sachs D.H., Gustafsson K., Pratt K., Germana S., Leguern C.;
RT "Class II genes of miniature swine. III. Characterization of an expressed
RT pig class II gene homologous to HLA-DQA.";
RL Immunogenetics 31:52-56(1990).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}.
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DR EMBL; M29939; AAA31083.1; -; mRNA.
DR PIR; I46606; I46606.
DR AlphaFoldDB; P15981; -.
DR SMR; P15981; -.
DR STRING; 9823.ENSSSCP00000070034; -.
DR PaxDb; 9823-ENSSSCP00000001574; -.
DR PeptideAtlas; P15981; -.
DR Ensembl; ENSSSCT00015099990.1; ENSSSCP00015041354.1; ENSSSCG00015063820.1.
DR Ensembl; ENSSSCT00015100056.1; ENSSSCP00015041384.1; ENSSSCG00015063820.1.
DR Ensembl; ENSSSCT00015101320.1; ENSSSCP00015041959.1; ENSSSCG00015063820.1.
DR eggNOG; ENOG502RXYJ; Eukaryota.
DR InParanoid; P15981; -.
DR Reactome; R-SSC-202424; Downstream TCR signaling.
DR Reactome; R-SSC-202427; Phosphorylation of CD3 and TCR zeta chains.
DR Reactome; R-SSC-202430; Translocation of ZAP-70 to Immunological synapse.
DR Reactome; R-SSC-202433; Generation of second messenger molecules.
DR Reactome; R-SSC-2132295; MHC class II antigen presentation.
DR Reactome; R-SSC-389948; PD-1 signaling.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Proteomes; UP000694570; Unplaced.
DR Proteomes; UP000694571; Unplaced.
DR Proteomes; UP000694720; Unplaced.
DR Proteomes; UP000694722; Unplaced.
DR Proteomes; UP000694723; Unplaced.
DR Proteomes; UP000694724; Unplaced.
DR Proteomes; UP000694725; Unplaced.
DR Proteomes; UP000694726; Unplaced.
DR Proteomes; UP000694727; Unplaced.
DR Proteomes; UP000694728; Unplaced.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050778; P:positive regulation of immune response; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR CDD; cd21008; IgC1_MHC_II_alpha_HLA-DQ; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR PANTHER; PTHR19944:SF59; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW MHC II; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT CHAIN 24..255
FT /note="SLA class II histocompatibility antigen, DQ
FT haplotype D alpha chain"
FT /id="PRO_0000018982"
FT TOPO_DOM 24..217
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..255
FT /note="Cytoplasmic"
FT DOMAIN 113..205
FT /note="Ig-like C1-type"
FT REGION 24..120
FT /note="Alpha-1"
FT REGION 121..204
FT /note="Alpha-2"
FT REGION 205..217
FT /note="Connecting peptide"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 133..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 255 AA; 28067 MW; CFCBDED8476FAC8C CRC64;
MVPGRVLMWG ALALTAVMSA CGGEDIAADH VASYGLNVYQ SYGPSGYYTH EFDGDEEFYV
DLGKKETVWQ LPLFSKFRSF DPQGALRNIA TAKHNLNILI KRSNNTAAVN QVPEVTVFPK
SPVMLGQPNT LICHVDNIFP PVINITWLKN GHSVTEGFSE TSFLSKNDHS FLKISYLTFL
PSDDDFYDCK VEHWGLDKPL LKHWEPEIPA PMSELTETVV CALGLIVGLV GIVVGTVFII
QGLRSGGPSR HQGSL
//
