ID HFQ_MOOTA Reviewed; 84 AA.
AC Q2RJF9;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=RNA-binding protein Hfq {ECO:0000255|HAMAP-Rule:MF_00436};
GN Name=hfq {ECO:0000255|HAMAP-Rule:MF_00436}; OrderedLocusNames=Moth_1116;
OS Moorella thermoacetica (strain ATCC 39073 / JCM 9320).
OC Bacteria; Bacillota; Clostridia; Moorellales; Moorellaceae; Moorella.
OX NCBI_TaxID=264732;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39073 / JCM 9320;
RX PubMed=18631365; DOI=10.1111/j.1462-2920.2008.01679.x;
RA Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C.,
RA Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W.;
RT "The complete genome sequence of Moorella thermoacetica (f. Clostridium
RT thermoaceticum).";
RL Environ. Microbiol. 10:2550-2573(2008).
CC -!- FUNCTION: RNA chaperone that binds small regulatory RNA (sRNAs) and
CC mRNAs to facilitate mRNA translational regulation in response to
CC envelope stress, environmental stress and changes in metabolite
CC concentrations. Also binds with high specificity to tRNAs.
CC {ECO:0000255|HAMAP-Rule:MF_00436}.
CC -!- SUBUNIT: Homohexamer. {ECO:0000255|HAMAP-Rule:MF_00436}.
CC -!- SIMILARITY: Belongs to the Hfq family. {ECO:0000255|HAMAP-
CC Rule:MF_00436}.
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DR EMBL; CP000232; ABC19430.1; -; Genomic_DNA.
DR RefSeq; YP_429973.1; NC_007644.1.
DR AlphaFoldDB; Q2RJF9; -.
DR SMR; Q2RJF9; -.
DR STRING; 264732.Moth_1116; -.
DR EnsemblBacteria; ABC19430; ABC19430; Moth_1116.
DR KEGG; mta:Moth_1116; -.
DR PATRIC; fig|264732.11.peg.1197; -.
DR eggNOG; COG1923; Bacteria.
DR HOGENOM; CLU_113688_0_2_9; -.
DR OrthoDB; 9799751at2; -.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01716; Hfq; 1.
DR Gene3D; 2.30.30.100; -; 1.
DR HAMAP; MF_00436; Hfq; 1.
DR InterPro; IPR005001; Hfq.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR047575; Sm.
DR NCBIfam; TIGR02383; Hfq; 1.
DR PANTHER; PTHR34772; RNA-BINDING PROTEIN HFQ; 1.
DR PANTHER; PTHR34772:SF1; RNA-BINDING PROTEIN HFQ; 1.
DR Pfam; PF17209; Hfq; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS52002; SM; 1.
PE 3: Inferred from homology;
KW RNA-binding; Stress response.
FT CHAIN 1..84
FT /note="RNA-binding protein Hfq"
FT /id="PRO_0000265166"
FT DOMAIN 10..70
FT /note="Sm"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01346"
SQ SEQUENCE 84 AA; 9527 MW; ECFE3C1D07166463 CRC64;
MNKTQGNLQD LFLNVLRRDN TPVTIYLVNG FQLKGVVRGF DNFTVVLDAD GKQQMIYKHA
ISTIMPFRPV NLMAESRAQA EAKQ
//
